Carbapenem Resistant Pseudomonas aeruginosa Infections in Elderly Patients: Antimicrobial Resistance Profiles, Risk Factors and Impact on Clinical Outcomes

Qin, Jie; Zou, Chengyun; Tao, Jianmin; Tian, Wei; Li, Yan; Zhang, Yufei; Wang, Haiying

doi:10.2147/idr.s358778

Cited by 11 publications

(5 citation statements)

References 40 publications

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“…14,40,41,42,21,32,22 As well as the greater risk of infection by resistant bacteria. 42 In addition to the risk factors directed to specific sites, other risk factors stood out as predictors of more frequent infections, such as length of stay in the ICU 14,34,39,17,34,39,17,33,18,20,21,22 , use of invasive devices 44,45,25,30,31,18,19,20,28,46 , advanced age 17,18,19,20,21,22 , comorbidities: diabetes mellitus 14, 47,30,48,49,50 , arterial hypertension 27 , chronic obstructive pulmonary disease 32 and smoking. 51 The identification of risk factors for infection in patients makes it possible to direct interventions with more assertive multidisciplinary approaches to achieve best practices and contribute to reducing the outcomes of HAI indicators 10 .…”

Section: Risk Factors For Respiratory Tract Infectionmentioning

confidence: 99%

Preventive Nurse Actions and Risk Factors Associated With Health Care Related Infections: A Narrative Review

Manica-Cattani,

Lunelli

2024

JHS

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In Brazil, it is estimated that 3% to 15% of hospitalized patients develop some kind of Healthcare-Associated Infection (HAI). The vast majority of HAIs are caused by an imbalance in the relationship between the normal human microbiota and the host's defense mechanisms and can affect both patients and healthcare professionals. Therefore, in this narrative review we sought to identify the main infection risk factors related to healthcare and list the main preventive actions taken by nurses within the hospital environment to avoid HAIs. The different risk factors related to healthcare in hospitalized adult patients found in the selected studies were described according to the sites of infection: urinary tract, primary bloodstream infection, surgical site and respiratory tract. And we list four practices that meet a consensus regarding some basic elements necessary for the prevention of HAIs. We can conclude that nurses' actions are essential for both the detection and prevention and control of HAIs.

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Section: Risk Factors For Respiratory Tract Infectionmentioning

confidence: 99%

Preventive Nurse Actions and Risk Factors Associated With Health Care Related Infections: A Narrative Review

Manica-Cattani,

Lunelli

2024

JHS

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“…Another example of an AMR bacteria is Pseudomonas aeruginosa ( P. aeruginosa ), whose adaptability makes them a significant threat to human health [ 35 ]. This Gram-negative bacterium can cause infections in animals, including both domestic and wild species [ 36 , 37 ]. It is listed as critical by WHO [ 28 ] (Group 1) due to its resistance to carbapenems.…”

Section: Priority Pathogens In Food-producing Animalsmentioning

confidence: 99%

The Silent Threat: Antimicrobial-Resistant Pathogens in Food-Producing Animals and Their Impact on Public Health

Almansour,

Alhadlaq,

Alzahrani

et al. 2023

Microorganisms

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The emergence of antimicrobial resistance (AMR) is a global health problem without geographic boundaries. This increases the risk of complications and, thus, makes it harder to treat infections, which can result in higher healthcare costs and a greater number of deaths. Antimicrobials are often used to treat infections from pathogens in food-producing animals, making them a potential source of AMR. Overuse and misuse of these drugs in animal agriculture can lead to the development of AMR bacteria, which can then be transmitted to humans through contaminated food or direct contact. It is therefore essential to take multifaceted, comprehensive, and integrated measures, following the One Health approach. To address this issue, many countries have implemented regulations to limit antimicrobial use. To our knowledge, there are previous studies based on AMR in food-producing animals; however, this paper adds novelty related to the AMR pathogens in livestock, as we include the recent publications of this field worldwide. In this work, we aim to describe the most critical and high-risk AMR pathogens among food-producing animals, as a worldwide health problem. We also focus on the dissemination of AMR genes in livestock, as well as its consequences in animals and humans, and future strategies to tackle this threat.

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“…[11,20] Opportunistic infection by this pathogen is seen primarily in patients treated in intensive care units. [17,21] It is one of the main microorganisms that cause nosocomial infections [22,23] and is responsible for up to 15 % of all infections worldwide, [24] which translates into more than two million infections and approximately 90,000 deaths per year. [23] It can also cause infections in individuals with reduced immunity, [21,25] severe burns, [24][25][26] cancer, [24,25] chronic obstructive pulmonary disease [24,27] or cystic fibrosis (CF).…”

Section: Introduction:the Antimicrobial Resistance "Crisis" and Pseud...mentioning

confidence: 99%

Diagnosis and Therapeutic Strategies Based on Nucleic Acid Aptamers Selected against Pseudomonas aeruginosa: The Challenge of Cystic Fibrosis

Gutiérrez‐Santana,

Coria‐Jiménez

2023

ChemMedChem

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Antimicrobial resistance (AMR) is a rapidly spreading global health problem, and approximately five million deaths associated with AMR pathogens were identified prior to the COVID‐19 pandemic. Pseudomonas aeruginosa has developed increasing AMR, and in patients with cystic fibrosis (CF) colonized by this bacterium, rare phenotypes have emerged that complicate the diagnosis and treatment of the hosts, in addition to multiple associated “epidemic strains” with high morbidities and mortalities. The conjugation of aptamers with fluorochromes or nanostructures has allowed the design of new identification strategies for Pseudomonas aeruginosa with detection limits of up to 1 cell ⋅ mL−1, and the synergy of aptamers with antibiotics, antimicrobial peptides and nanostructures has exhibited promising therapeutic qualities. Some selected aptamers against this bacterium have shown intrinsic antimicrobial activity. However, these aptamers have been poorly evaluated in clinical isolates and have shown decreased interactions for CF isolates, demonstrating, in these cases, uncommon phenotypes resulting from the selective qualities of this disease as well as the great adaptive capacity of the pathogen. Therefore, finding an aptamer or set of aptamers that have the ability to recognize strange phenotypes of this bacillus is crucial in the battle against AMR.

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Carbapenem Resistant Pseudomonas aeruginosa Infections in Elderly Patients: Antimicrobial Resistance Profiles, Risk Factors and Impact on Clinical Outcomes

Cited by 11 publications

References 40 publications

Preventive Nurse Actions and Risk Factors Associated With Health Care Related Infections: A Narrative Review

Preventive Nurse Actions and Risk Factors Associated With Health Care Related Infections: A Narrative Review

The Silent Threat: Antimicrobial-Resistant Pathogens in Food-Producing Animals and Their Impact on Public Health

Diagnosis and Therapeutic Strategies Based on Nucleic Acid Aptamers Selected against Pseudomonas aeruginosa: The Challenge of Cystic Fibrosis

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