Bacterial Community Profile of the Gut Microbiota Differs between Hypercholesterolemic Subjects and Controls

Rebolledo, Camilo; Cuevas, Alejandro; Zambrano, Tomás; Acuña, Jacquelinne J.; Jorquera, Milko A.; Saavedra, Kathleen; Martínez, Claudio; Lanas, Fernando; Serón, Pamela; Salazar, Luis A.; Saavedra, Nicolás

doi:10.1155/2017/8127814

Cited by 31 publications

(29 citation statements)

References 32 publications

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“…In this study, Rebolledo et al analyzed the fasting whole blood lipid profile and bacterial community profiles by denaturing gradient gel electrophoresis. As expected, hypercholesterolemia subjects had higher levels of serum total cholesterol, triglycerides, and LDL-cholesterol than controls, while they harbored a lower richness and diversity of gut microbiota, thus proposing a potential role of the gut microbiota in the development of hypercholesterolemia [44]. Karlsson et al performed the metagenomic sequencing with fecal samples collected from 145 European women with normal, impaired, or diabetic glucose control, and reported a negative correlation between serum triglycerides and Clostridum, and a positive correlation between HDL and Clostridium [45].…”

Section: The Association Between the Gut Microbiome And Lipid Profilesupporting

confidence: 56%

“…In addition, a study of 30 hypercholesterolemia individuals and 27 healthy controls reported differences in commensal bacterial profiles between hypercholesterolemic subjects and controls [44]. In this study, Rebolledo et al analyzed the fasting whole blood lipid profile and bacterial community profiles by denaturing gradient gel electrophoresis.…”

Section: The Association Between the Gut Microbiome And Lipid Profilementioning

confidence: 95%

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The Role of the Gut Microbiota in Lipid and Lipoprotein Metabolism

Raka

Adeli

2019

JCM

106

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Both environmental and genetic factors contribute to relative species abundance and metabolic characteristics of the intestinal microbiota. The intestinal microbiota and accompanying microbial metabolites differ substantially in those who are obese or have other metabolic disorders. Accumulating evidence from germ-free mice and antibiotic-treated animal models suggests that altered intestinal gut microbiota contributes significantly to metabolic disorders involving impaired glucose and lipid metabolism. This review will summarize recent findings on potential mechanisms by which the microbiota affects intestinal lipid and lipoprotein metabolism including microbiota dependent changes in bile acid metabolism which affects bile acid signaling by bile acid receptors FXR and TGR5. Microbiota changes also involve altered short chain fatty acid signaling and influence enteroendocrine cell function including GLP-1/GLP-2-producing L-cells which regulate postprandial lipid metabolism.

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Section: The Association Between the Gut Microbiome And Lipid Profilesupporting

confidence: 56%

Section: The Association Between the Gut Microbiome And Lipid Profilementioning

confidence: 95%

The Role of the Gut Microbiota in Lipid and Lipoprotein Metabolism

Raka

Adeli

2019

JCM

106

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“…Additionally, the profile of the microorganisms that are present is different, which suggests that IM possibly play a role in development of hypercholesterolemia. 7 Manipulation of the IM with probiotics results in several benefits for the host. 8,9 Probiotics are already in use in human medicine, both for disease prevention and for treatment, by controlling the IM.…”

Section: Introductionmentioning

confidence: 99%

Efeitos dos probióticos no perfil lipídico: revisão sistemática

Gadelha

Bezerra

2019

J. vasc. bras.

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Resumo As alterações na microbiota intestinal podem modular mecanismos envolvendo fatores de risco para doenças cardiovasculares, incluindo as dislipidemias. O objetivo foi revisar os efeitos da suplementação de probióticos na prevenção e no tratamento de alterações do perfil lipídico. As pesquisas foram feitas na base de dados PubMed, com os descritores “probiotics and lipid profile” e “probiotics and dyslipidemia”, em artigos publicados entre 2013 e 2018. A suplementação com probióticos reduziu significativamente o colesterol total, o colesterol LDL (lipoproteína de baixa densidade) e os triglicerídeos, assim como aumentou o colesterol HDL (lipoproteína de alta densidade). Alguns benefícios foram observados sobre variáveis antropométricas, de controle glicêmico, de estresse oxidativo, de inflamação e do sistema imune. O presente estudo sugere que a suplementação de probióticos seja indicada como tratamento coadjuvante às dislipidemias. Novos estudos devem ser desenvolvidos com a finalidade de esclarecer os efeitos de longo prazo, assim como a influência dos probióticos em associação com o tratamento medicamentoso.

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“…between patients with diabetes and healthy individuals. It is previously reported that total cholesterol and low-density lipoprotein cholesterol reduction are associated with dairy products enriched with Enterococcus faecium in participant having a normal lipid profile and participant with medium to moderate hypercholesterolemia [38].…”

Section: Discussionmentioning

confidence: 96%

Identification of an intestinal microbiota signature associated with hospitalized patients with diarrhea

Mohammadzadeh

Kalani

Bolori

et al. 2019

AMicr

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As an important global health challenge, diarrhea kills nearly two million people each year. Postinfectious irritable bowel syndrome (IBS) usually manifests itself as the diarrhea-predominant subtype. Small intestinal bacterial overgrowth has been observed more frequently in patients with IBS compared to healthy controls. However, the pathophysiology of IBS is not fully understood, and based on recent evidences, altered gut microbiota is involved in the pathogenesis of IBS. Therefore, we aimed to compare the microbiome in hospitalized patients with diarrhea and healthy individuals. Thirty patients and 10 healthy controls were included into this case–control study. Microbial count was performed using quantitative real-time polymerase chain reaction method using bacterial 16S rRNA gene. Clostridium cluster IV and Bacteroides were significantly more frequent in the patients compared with the healthy individuals (p = 0.02 and 0.023, respectively). However, the quantity of Enterococcus and Bifidobacterium groups were significantly higher in healthy controls than in diarrheal group (p = 0.000076 and 0.001, respectively). The results showed that the number of bacteria in all bacterial groups was significantly different between healthy individuals and diabetic group, whereas the difference between the healthy group and IBS was not significant for Bifidobacterium group. The findings of this study outlined the relationship between diarrhea, IBS, and diabetes disease and bacterial composition. It could be concluded that modifying the bacterial composition by probiotics can be helpful in the control and management of the mentioned disease.

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Bacterial Community Profile of the Gut Microbiota Differs between Hypercholesterolemic Subjects and Controls

Cited by 31 publications

References 32 publications

The Role of the Gut Microbiota in Lipid and Lipoprotein Metabolism

The Role of the Gut Microbiota in Lipid and Lipoprotein Metabolism

Efeitos dos probióticos no perfil lipídico: revisão sistemática

Identification of an intestinal microbiota signature associated with hospitalized patients with diarrhea

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