Bacterial Biopolymer: Its Role in Pathogenesis to Effective Biomaterials

Ghosh, Sreejita; Lahiri, Dibyajit; Nag, Moupriya; Dey, Ankita; Sarkar, Tanmay; Pathak, Sushil Kumar; Edinur, Hisham Atan; Pati, Siddhartha; Ray, Rina Rani

doi:10.3390/polym13081242

Cited by 38 publications

(14 citation statements)

References 138 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The intestine not only has diverse functions, such as digestion, absorption, secretion but also is the main component of the body's mucosal immune system (Ghosh et al, 2021 ; Kurashima et al, 2013 ). The intestinal mucosal immune system deals with the stimulation of tens of millions of antigens including pathogens, food proteins, and microbiome everyday (Heller & Duchmann, 2003 ; Kurashima et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

The regulatory effects of Pseudostellaria heterophylla polysaccharide on immune function and gut flora in immunosuppressed mice

Kan

Liu

Huang

et al. 2022

Food Science & Nutrition

View full text Add to dashboard Cite

Polysaccharide (PF40) has been recognized as a main bioactive substances inPseudostellaria heterophylla (Miq.). The current study explored the potential protective effects of PF40 on immune system in mice with cyclophosphamide-induced immunosuppression. The mice were intragastric administered PF40 at the dosage of 100, 200 or 400 mg/kg once daily for 30 days, On the 24th and 25th day, the additional intraperitoneal injection of PF40 (50 mg/kg) were administered. The results showed that PF40 enhanced the cell-mediated immunity via improvements in macrophage phagocytosis, splenocyte proliferation, NK cell activity and delayed type hypersensitivity. Equally, it improves humoral immunity through promoting the formation of serum hemolysin.Moreover, PF40 maintain the immune balance of splenic lymphocytes and altered the intestinal physiological status in Cyp-induced mice. PF40 regulates the intestinal microbiota by restoring the relative abundance of Odoribacter and Mucispirillum and reducing the relative abundance of Sporosarcina, Yaniella, and Jeotgalicoccus in Cypintervened mice. The findings suggested that PF40 might be a promising natural functional foods for reducing chemotherapy-induced immunosuppression.

show abstract

Section: Discussionmentioning

confidence: 99%

The regulatory effects of Pseudostellaria heterophylla polysaccharide on immune function and gut flora in immunosuppressed mice

Kan

Liu

Huang

et al. 2022

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

“…Biofilm refers to a consortium of microorganisms that remain embedded within the self-produced extracellular polymeric substances (EPS) upon the biotic or abiotic inert surface [ 101 ]. EPS includes exopolysaccharides, proteins, and extracellular DNA, which manifest the strong barrier against any external stresses such as antibiotics or host immune responses [ 102 ]. Biofilm is responsible for 80% of the microbial infections associated with bacteria, fungi, protozoa, viruses, or bacteriophages in the human body [ 103 ].…”

Section: Antibiofilm Activities Of Bc Compositesmentioning

confidence: 99%

Bacterial Cellulose: Production, Characterization, and Application as Antimicrobial Agent

Lahiri

Nag

Dutta

et al. 2021

IJMS

Self Cite

129

View full text Add to dashboard Cite

Bacterial cellulose (BC) is recognized as a multifaceted, versatile biomaterial with abundant applications. Groups of microorganisms such as bacteria are accountable for BC synthesis through static or agitated fermentation processes in the presence of competent media. In comparison to static cultivation, agitated cultivation provides the maximum yield of the BC. A pure cellulose BC can positively interact with hydrophilic or hydrophobic biopolymers while being used in the biomedical domain. From the last two decades, the reinforcement of biopolymer-based biocomposites and its applicability with BC have increased in the research field. The harmony of hydrophobic biopolymers can be reduced due to the high moisture content of BC in comparison to hydrophilic biopolymers. Mechanical properties are the important parameters not only in producing green composite but also in dealing with tissue engineering, medical implants, and biofilm. The wide requisition of BC in medical as well as industrial fields has warranted the scaling up of the production of BC with added economy. This review provides a detailed overview of the production and properties of BC and several parameters affecting the production of BC and its biocomposites, elucidating their antimicrobial and antibiofilm efficacy with an insight to highlight their therapeutic potential.

show abstract

“…Nanomaterials can have one, two, or three dimensions in the nanoscale, as exemplified by nanotubes, nanorods, nanoflowers, nanowires, nanofibers, fullerenes, dendrimers, and quantum dots (Tripathi and Chung, 2019). The microbiogenically synthesized nanostructures are preferred for their affectivity, convenience in production, and environment-friendliness (Ghosh et al, 2021). The microbial synthesis of NPs possesses various types of advantages in comparison to the other methods that include synthesis of nanomaterials with definite morphology, size, and chemical compositions.…”

Section: Microbial Synthesis Of Nanomaterialsmentioning

confidence: 99%

Microbial Fabrication of Nanomaterial and Its Role in Disintegration of Exopolymeric Matrices of Biofilm

et al. 2021

Self Cite

View full text Add to dashboard Cite

Bacterial biofilms are responsible for the development of various chronic wound-related and implant-mediated infections and confer protection to the pathogenic bacteria against antimicrobial drugs and host immune responses. Hence, biofilm-mediated chronic infections have created a tremendous burden upon healthcare systems worldwide. The development of biofilms upon the surface of medical implants has resulted in the failure of various implant-based surgeries and therapies. Although different conventional chemical and physical agents are used as antimicrobials, they fail to kill the sessile forms of bacterial pathogens due to the resistance exerted by the exopolysaccharide (EPS) matrices of the biofilm. One of the major techniques used in addressing such a problem is to directly check the biofilm formation by the use of novel antibiofilm materials, local drug delivery, and device-associated surface modifications, but the success of these techniques is still limited. The immense expansion in the field of nanoscience and nanotechnology has resulted in the development of novel nanomaterials as biocidal agents that can be either easily integrated within biomaterials to prevent the colonization of microbial cells or directly approach the pathogen overcoming the biofilm matrix. The antibiofilm efficacies of these nanomaterials are accomplished by the generation of oxidative stresses and through alterations of the genetic expressions. Microorganism-assisted synthesis of nanomaterials paved the path to success in such therapeutic approaches and is found to be more acceptable for its “greener” approach. Metallic nanoparticles functionalized with microbial enzymes, silver–platinum nanohybrids (AgPtNHs), bacterial nanowires, superparamagnetic iron oxide (Fe3O4), and nanoparticles synthesized by both magnetotactic and non-magnetotactic bacteria showed are some of the examples of such agents used to attack the EPS.

show abstract

Bacterial Biopolymer: Its Role in Pathogenesis to Effective Biomaterials

Cited by 38 publications

References 138 publications

The regulatory effects of Pseudostellaria heterophylla polysaccharide on immune function and gut flora in immunosuppressed mice

The regulatory effects of Pseudostellaria heterophylla polysaccharide on immune function and gut flora in immunosuppressed mice

Bacterial Cellulose: Production, Characterization, and Application as Antimicrobial Agent

Microbial Fabrication of Nanomaterial and Its Role in Disintegration of Exopolymeric Matrices of Biofilm

Contact Info

Product

Resources

About