Aβ(42) induced MRI changes in aged rabbit brain resembles AD brain

Cholesterol Increases Ventricular Volume in a Rabbit Model of Alzheimer's Disease

“…A recent study by Ramesh and colleagues used an acute intracisternal injection of Aβ in aged rabbits to determine changes in the brain [52]. Of particular relevance to the present study was a finding of increased ventricular width that occurred 45 days after the injection of Aβ.…”

“…The current data appear to confirm this overall finding although the differences observed here were in the third ventricle and not the lateral ventricle and were based on ventricular volume and not ventricular width. Given the variety of species and effects of Aβ [63–68], the present differences may be the result of slowly accumulating, endogenous, intracellular Aβ compared to acutely injected, exogenous, extracellular Aβ [52]. …”

“…Interestingly, Chen and co-workers noted ventricular enlargement in normal mice as a function of age using a 7.0 T MRI scanner [50] suggesting enlargement may simply be a function of age in this model [51]. A recent study by Ramesh and colleagues showed that an intracisternal injection of Aβ into the brains of aged rabbits reduced cortical thickness and increased the thickness of the lateral ventricles when measured 45 days after treatment [52]. We have previously used magnetic resonance angiographic imaging at 3.0 T to report changes in the cerebrovasculature of cholesterol-fed rabbits [53].…”

First magenetic resonance imaging studies on aluminium maltolate‐treated aged New Zealand rabbits: an Alzheimer's animal model

“…thalamus, cerebral cortex and caudoputamen), the accrual of ventricles and white matter (corpus callosum, corticospinal tract, fornix system) volume, and volume loss in the cortex and hippocampus in transgenic mice; and results in amyloid plaques deposition in ex vivo transgenic APP and APP/ presenilin‐1 mouse brains of AD mouse models . However, amyloid β‐injected rabbits did not demonstrate these volumetric changes within 25 days, but after 60 days, these rabbits demonstrated significant volumetric changes in the temporal lobe and lateral ventricles . In this study, Al‐M‐treated aged New Zealand rabbit showed significant volumetric changes in the temporal lobe and ventricles.…”

Dietary cholesterol increases ventricular volume and narrows cerebrovascular diameter in a rabbit model of Alzheimer’s disease

“…Interestingly, Chen and co-workers noted ventricular enlargement in normal mice as a function of age using a 7.0 Tesla MRI scanner (Chen et al, 2010) suggesting enlargement may simply be a function of age in this model (Fjell et al, 2009). A study by Ramesh and colleagues showed that intracisternal injection of beta amyloid into the brains of aged rabbits reduced cortical thickness and increased the thickness of the lateral ventricles when measured 45 days after treatment (Ramesh et al, 2011). …”