Aztreonam failure in typhoid fever

Choo, K. E.; Ariffin, W A; Ong, K; Sivakumaran, Soori

doi:10.1016/0140-6736(91)93439-g

Cited by 6 publications

(3 citation statements)

References 3 publications

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“…This antibiotic has been shown to be more effective than chloramphenicol in clearing the organism from the blood and it is associated with fewer adverse reactions. However, a prospective clinical trial which was carried out among children in Malaysia was discontinued because of a high failure rate with aztreonam [39]. Azithromycin shows some promise for the management of uncomplicated typhoid fever and it may provide a useful alternative to ceftriaxone in thesettings where a cheaper oral regimen is needed.…”

Section: Discussionmentioning

confidence: 99%

Increasing Antimicrobial Resistance and Narrowing Therapeutics in Typhoidal Salmonellae

Kaurthe¹

2013

JCDR

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Section: Discussionmentioning

confidence: 99%

Increasing Antimicrobial Resistance and Narrowing Therapeutics in Typhoidal Salmonellae

Kaurthe¹

2013

JCDR

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“…Aztreonam and cefixime have had variable success rates and are not considered first-line therapy [65,[74][75][76]. Firstand second-generation cephalosporins, as well as aminoglycosides, are ineffective [77,78].…”

Section: Treatmentmentioning

confidence: 99%

Current trends in typhoid fever

Crum

2003

Curr Gastroenterol Rep

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Typhoid fever, a systemic infection caused by Salmonella enterica serotype typhi, remains an important worldwide cause of morbidity and mortality. Endemic cases in the United States are unusual, with most following foreign travel to the Indian subcontinent, Africa, Asia, or Latin America. The classic findings of typhoid fever include rose spots, relative bradycardia, and stepwise fevers, but unfortunately these signs are frequently absent. Gastrointestinal manifestations may include diffuse abdominal pain, bleeding, perforation, cholecystitis, and cholangitis. The diagnosis should be suspected after collection of the appropriate clinical and travel history with confirmation by blood or bone marrow culture. Novel methods are in development to establish the diagnosis when cultures are negative or unavailable. Multidrug resistance has increased worldwide, and decisions on antimicrobial therapy must take such resistance into account. The empiric treatment of choice is a fluoroquinolone drug; ceftriaxone and azithromycin are alternatives. Preventive strategies include good sanitation and food handling practices along with vaccination of selected groups.

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“…This antibiotic has been shown to be more effective than chloramphenicol in clearing the organism from the blood and was associated with fewer adverse reactions. However, a prospective clinical trial in children in Malaysia was discontinued because of a high failure rate with aztreonam [21]. Azithromycin, a new macrolide antibiotic administered in a dose of 1 gram once daily for 5 days is also useful for the treatment of typhoid fever, although the disease takes longer to defervesce [22,23].…”

Section: Treatmentmentioning

confidence: 99%