Current Trends in the Management of Typhoid Fever

Kalra, S P; Naithani, Nardeep; Mehta, SR; Swamy, AJ

doi:10.1016/s0377-1237(03)80060-6

Cited by 42 publications

(32 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In UK, there is approximately one case per 100,000 population per year. 12 Definitive treatment of typhoid fever is based on susceptibility. Until susceptibilities are determined, antibiotic should be empirical.…”

Section: Clinical Efficacy Of Azithromycin In Typhoid and Paratyphoidmentioning

confidence: 99%

Clinical Efficacy of Azithromycin in Typhoid and Paratyphoid Fever in Children

Islam¹,

Mobarak²,

Hasan³

et al. 2015

J Enam Med Col

View full text Add to dashboard Cite

Background: Azithromycin sensitivity cannot precisely identify the strains of typhoid and paratyphoid fever for successful treatment. Most of the studies show that azithromycin is highly effective in uncomplicated typhoid fever. Very few studies have been carried out in Bangladesh to see the effectiveness and sensitivity of azithromycin in children with uncomplicated typhoid fever. Objective: To assess the clinical response of azithromycin in uncomplicated typhoid fever. Materials and Methods: This randomized clinical trial was conducted in Dhaka Shishu (children) Hospital from January to December 2009. Children between 212 years of age with characteristic clinical presentation of uncomplicated typhoid fever with positive blood culture for S. typhi or S. paratyphi were included in this study. Patients were treated with oral azithromycin 20 mg/kg/day for 7 days in one group and intravenous ceftriaxone 100 mg/kg/day in another group. Effectiveness and sensitivity pattern were documented and compared. Results: Fifty patients were allocated randomly with azithromycin and 48 with ceftriaxone. Twenty two percent of the subjects were below 5 years and 78% above 5 years. Average time of defervescence was 4.44 ± 1.25 days in azithromycin group and 4.38 ± 1.21 days in ceftriaxone group. Response to treatment in both groups was excellent: 94% in azithromycin and 97.9% in ceftriaxone groups. The occurrence of complication was very low in both groups. Eighteen percent showed resistance to azithromycin and 2.1% to ceftriaxone. In azithromycin sensitive group 97.6% showed improvement and in resistant group 77.8% showed improvement. A good percentage of patients who were resistant to azithromycin showed clinical improvement following treatment with this drug. Conclusion: Current study recommends that azithromycin is effective in the treatment of enteric fever in children. The study also shows that some patients resistant to azithromycin showed clinical improvement following treatment with azithromycin. DOI: http://dx.doi.org/10.3329/jemc.v5i1.21495 J Enam Med Col 2015; 5(1): 34-38

show abstract

Section: Clinical Efficacy Of Azithromycin In Typhoid and Paratyphoidmentioning

confidence: 99%

Clinical Efficacy of Azithromycin in Typhoid and Paratyphoid Fever in Children

Islam¹,

Mobarak²,

Hasan³

et al. 2015

J Enam Med Col

View full text Add to dashboard Cite

show abstract

“…This index case had ceftriaxone and azithromycin resistant S typhi , not earlier reported from India 5 , 6. Third generation cephalosporins have been recommended as an alternative to quinolone treatment in enteric fever and several scientists have claimed good results with them, particularly with ceftriaxone 7.…”

Section: Discussionmentioning

confidence: 73%

Is drug-resistant Salmonella typhi an emerging threat?

Kulkarni

Singh²,

Kumar³

2009

Case Reports

View full text Add to dashboard Cite

Enteric fever is a common cause of morbidity and mortality worldwide and more so in a developing country like India. Worldwide, the incidence of multidrug Salmonella typhi is increasing alarmingly. Similarly, a multiplicity of factors affects the in vivo susceptibility of a microorganism. We report a case of multidrug resistant complicated enteric fever with resistance to ceftriaxone and azithromycin.

show abstract

“…The results of this study were related to cefotaxime which was the most widely used antibiotic for the treatment of typhoid fever in pediatric patients. Cefotaxime is class III cephalosporin group that has a very wide spectrum, its antibacterial activity is stronger, and side effects are relatively lower [17].…”

Section: Discussionmentioning

confidence: 99%

The Rationality of Antibiotics Therapy Toward Children With Typhoid Fever at M.M. Dunda Hospital

Tuloli

Moo

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objectives: Typhoid fever is an acute systemic infectious disease in the small intestine caused by Salmonella enterica serotype typhi (Salmonella typhi) having the symptoms of fever a week or more with impairment of the gastrointestinal tract with or without impaired consciousness. The purpose of this study was to determine the rationality of antibiotic therapy in pediatric patients at M.M Dunda Limboto Hospital.Methods: This research belongs to non-experimental descriptive with retrospective data retrieval. The data used were obtained from 83 medical records of childhood typhoid patients during 6 months (June–November 2016) at the regional general hospital of M.M Dunda Limboto. These data were analyzed using the Gyssens criteria.Results: The results showed that the most antibiotics used by physicians were ceftriaxone 39% of the use of antibiotic quality which was category IIB 9%, category IIA 13%, and category 0 (rational) 52%.Conclusion: The rationality of antibiotic therapy in children with typhoid fever at M.M Dunda Limboto Hospital was 52% of the most antibiotics used, i.e. ceftriaxone (39%).

show abstract

Current Trends in the Management of Typhoid Fever

Cited by 42 publications

References 26 publications

Clinical Efficacy of Azithromycin in Typhoid and Paratyphoid Fever in Children

Clinical Efficacy of Azithromycin in Typhoid and Paratyphoid Fever in Children

Is drug-resistant Salmonella typhi an emerging threat?

The Rationality of Antibiotics Therapy Toward Children With Typhoid Fever at M.M. Dunda Hospital

Contact Info

Product

Resources

About