Ayurveda and botanical drugs for epilepsy: Current evidence and future prospects

Sriranjini, S. J.; Sandhya, K; Mamta, Vernekar Sanjeeva

doi:10.1016/j.yebeh.2015.05.039

Cited by 39 publications

(7 citation statements)

References 136 publications

(75 reference statements)

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“…reviewed medicinal antiepileptic plants used in Iran and listed 11 such herbal remedies [ 33 ]. Sriranjini et al ., reviewed some antiepileptic botanicals used with respect to ayurverda [ 8 ] while Tagarelli et al . summarized 12 herbal remedies used in Italy [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

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Recent Advances in Antiepileptic Herbal Medicine

Manchishi

2017

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Background:Epilepsy is one of the most common neurological disorders worldwide, with about 80 percent of cases thought to be in developing nations where it is mostly linked to superstition. The limited supply, high cost as well as low efficacy and adverse side effects of antiepileptic drugs (AEDs) is a matter of major concern. Herbal medicine has always been traditionally part of treatment of epilepsy. Herbal medicines are generally well tolerated, with fewer side effects.Method:To highlight some herbal extracts that have been studied for their anticonvulsant activity in animal models, literature search from PubMed and Science Direct, was performed. The keywords for the search consisted of combinations of the following terms: Herbal antiepileptic and/or anticonvulsant, botanicals + epilepsy. Literature published in the last five years was considered.Results:Eighteen (18) anticonvulsant herbal agents are reported and discussed. Experiments mostly consisted of phenotypic screens in rodents, with little diversity in screening methods. In most experiments, the tested extracts prolonged the time to onset of seizures and decreased their duration. Most experimenters implicate potentiation of GABAergic activity as the mode of action of the extracts, even though some experimenters did not fully characterise the bioactive chemical composition of their extracts.Conclusion:Potential herbal remedies have shown positive results in animal models. It remains unclear how many make it into clinical trials and eventually making part of the AED list. More rigorous research, applying strict research methodology with uniform herbal combinations, as well as clinical studies are urgently needed.

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Section: Resultsmentioning

confidence: 99%

“…Most Antiepileptic drugs (AEDs) do not prevent or reverse the pathological process that underlies epilepsy, hence the continuing search for new therapies with fewer side effects and better efficacy [ 8 ]. Moreover, 30–40% of patients typically develop pharmacoresistant or intractable epilepsy [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Antiepileptic Herbal Medicine

Manchishi

2017

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“…It is used in many polyherbal formulations to treat diseases. It is one of the tested herbs in Ayurveda for anticonvulsant activity [31]. The whole dried plant acts as a good tonic, expectorant and antihelminthic agent [32].…”

Section: Introductionmentioning

confidence: 99%

Calotropis procera (Arka): A Tribal Herb of Utmost Significance

Kumari¹,

Chaudhary²

2021

Int. j. res. appl. sci. biotechnol.

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Nature has gifted humans a vast variety of medicinal plants, which are the rich source of bioactive compounds. Calotropis procera is an important medicinal plant that belongs to the family asclepiadaceae. It is commonly known as madar and milkweed plant in english and arka in hindi. It is mostly found in the tropics of asia and africa. Calotropis procera is a highly valued plant in the folk medication system. Each part of the plant is richly endowed with diverse nature of phytochemical constituents like alkaloids, proteins, vitamins, carbohydrates, saponins, terpenes, and flavonoids, etc. These phytochemicals are significantly associated with various therapeutic and pharmacological properties such as anti-microbial, anti-oxidant, anti-inflammatory, anti-ulcer, antifertility, anti-diarrheal, and spasmolytic. In this review article, the therapeutic and pharmacological value of this important plant has been summarized along with its utilization in the folklore and ayurvedic medicinal system.

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“…[5] Most antiepileptic drugs do not prevent or reverse the pathological process that underlies epilepsy, hence the continued search for new treatments with fewer side effects and improved efficacy. [6] Herbal medicine plays a crucial part in meeting the population's primary health care needs, with Africa and Asia being the continents with most users. [7] Several other medicinal plants have shown potential for new, safe possible treatments.…”

Section: Introductionmentioning

confidence: 99%

Preventive Effect of Phaseolus Vulgaris Seed Coats on Pentylenetetrazole (Ptz) Induced Kindling and Behavioral Comorbidities

Chaudhary¹,

Majhi²,

Verma³

2021

J App Pharm Sci Res

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Introduction: To investigate the preventive effect of Phaseolus vulgaris seed coats on pentylenetetrazole-induced kindling and behavioral comorbidities. Material and Methods: Thirty Wistar albino rats were categorized into five groups. The first group received regular saline (0.9 % w/v NaCl) p.o.; the second group received PTZ (35 mg/kg b.w.) i.p.; the third group received valproic acid (200 mg/kg b.w.) p.o.; the fourth group received P. vulgaris extract (100 mg/kg b.w.) p.o.; the fifth group received P. vulgaris extract (200 mg/kg b.w.) p.o. on an alternate day for 21 days. PTZ improved lipid peroxidase levels, decreased Glutathione level, decreased superoxide dismutase activity, increased Nitric Oxide level. Result: This study revealed that P. vulgaris (Hydroalcoholic extract) increased the anti-oxidant level of both 100 mg/kg and 200 mg/kg compared to the PTZ category. Histopathological findings revealed that the hippocampal section of the brain of rats receiving P. vulgaris extract had improved relative to the receiving PTZ group. Conclusion: Based on the result, it is proposed that Phaseolus vulgaris has anti-oxidant properties. This is useful for the treatment of epilepsy.

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Ayurveda and botanical drugs for epilepsy: Current evidence and future prospects

Cited by 39 publications

References 136 publications

Recent Advances in Antiepileptic Herbal Medicine

Recent Advances in Antiepileptic Herbal Medicine

Calotropis procera (Arka): A Tribal Herb of Utmost Significance

Preventive Effect of Phaseolus Vulgaris Seed Coats on Pentylenetetrazole (Ptz) Induced Kindling and Behavioral Comorbidities

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