Avian hepatitis E virus is widespread among chickens in Poland and belongs to genotype 2

Matczuk, Anna Karolina; Ćwiek, Katarzyna; Wieliczko, Alina

doi:10.1007/s00705-018-4089-y

Cited by 13 publications

(20 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This figure shows that the avian HEV strains from Korea are part of genotypes 1 and 2 of Orthohepevirus B, which was previously thought to only include avian strains from Australia and the USA; in contrast, the Chinese and Taiwanese avian strains are part of genotypes 3 and 4, respectively, which were previously thought to only include avian strains from Hungary. The members of Orthohepevirus B are associated with big liver and spleen disease and hepatitis-splenomegaly syndrome [77].…”

Section: Taxonomymentioning

confidence: 99%

Genetic Variability and Evolution of Hepatitis E Virus

Primadharsini

Nagashima

Okamoto

2019

Viruses

View full text Add to dashboard Cite

Hepatitis E virus (HEV) is a single-stranded positive-sense RNA virus. HEV can cause both acute and chronic hepatitis, with the latter usually occurring in immunocompromised patients. Modes of transmission range from the classic fecal–oral route or zoonotic route, to relatively recently recognized but increasingly common routes, such as via the transfusion of blood products or organ transplantation. Extrahepatic manifestations, such as neurological, kidney and hematological abnormalities, have been documented in some limited cases, typically in patients with immune suppression. HEV has demonstrated extensive genomic diversity and a variety of HEV strains have been identified worldwide from human populations as well as growing numbers of animal species. The genetic variability and constant evolution of HEV contribute to its physiopathogenesis and adaptation to new hosts. This review describes the recent classification of the Hepeviridae family, global genotype distribution, clinical significance of HEV genotype and genomic variability and evolution of HEV.

show abstract

Section: Taxonomymentioning

confidence: 99%

Genetic Variability and Evolution of Hepatitis E Virus

Primadharsini

Nagashima

Okamoto

2019

Viruses

View full text Add to dashboard Cite

show abstract

“…There is a 20% positive rate for anti-avian HEV antibodies in chickens from Brazil (Vitral et al, 2005), and in Spain, positive rates for farms span a wide range from 20 to 80% (Peralta et al, 2009). In China, the avian HEV seropositive rate in chicken flocks is 35.9% (Zhao et al, 2013a), while in Poland, there is a 56.1% positive rate for avian HEV genotype 2 among breeder broiler and egg laying hen flocks (Matczuk et al, 2019). In the United States between the years 2012 and 2014, 141 chickens from 10 organic layer flocks showed a 40% decrease in the rate of egg production and slightly increased mortality (up to 1% per week), avian HEV RNA was detected in 10 livers out of 141 chickens from two different affected flocks (Crespo et al, 2015).…”

Section: Epidemiologymentioning

confidence: 99%

“…Genotype 1, was primarily isolated from BLS chickens in Australia and was also reported to cause the decrease in egg production in chickens during an outbreak in Korea (Payne et al, 1999; Kwon et al, 2012). Genotype 2, was primarily isolated from HSS chickens in the United States and was detected in BLS flocks in Central Europe and Poland, and also isolated from chickens with hepatitis-splenomegaly syndrome in Korea (Haqshenas et al, 2001; Moon et al, 2016; Matczuk et al, 2019). Genotype 3, was isolated from HSS chickens in Europe and from hens with decreased egg laying in China (Morrow et al, 2008; Zhao et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Avian Hepatitis E Virus: With the Trend of Genotypes and Host Expansion

Sun

Lin

et al. 2019

Front. Microbiol.

View full text Add to dashboard Cite

Avian hepatitis E virus (HEV) is a single-stranded, positive-sense RNA virus with a complete genome of approximately 6.6 kb in size. To date, four major genotypes of avian HEV have been identified and classified into the Orthohepevirus B genus of the family Hepeviridae . The avian HEV associated with hepatitis-splenomegaly syndrome, big liver and spleen disease or hepatic rupture hemorrhage syndrome in chickens is genetically and antigenically related to mammalian HEV. With the increased genotypes of avian HEV identified, a broader host tropism is also notable in the epidemiological studies. Due to the lack of an efficient cell culture system, the mechanisms of avian HEV replication and pathogenesis are still poorly understood. The recent identification and characterization of animal strains of avian HEV has demonstrated the virus’ ability of cross-species infection. Although it has not yet been detected in humans, the potential threat of a zoonotic HEV capable of transmission to humans needs to be taken into consideration. This review article focuses on the current knowledge regarding avian HEV in virology, epidemiology, pathogenesis, clinical presentation, transmission, diagnosis and prevention. HIGHLIGHTS - The mechanisms of avian HEV replication and pathogenesis are still poorly understood due to the lack of an efficient cell culture system. - A broader host tropism is also notable in the epidemiological studies with the increased genotypes of avian HEV identified. - The recent identification and characterization of animal strains of avian HEV has demonstrated the virus’ ability of cross-species infection. - The potential threat of a zoonotic HEV capable of transmission to humans needs to be taken into consideration.

show abstract

“…This study also shows that other animal species including chickens and wild boar, already identified as a reservoir of HEV are not yet studied in Africa. It is therefore necessary to perform investigations in these animals [ 64 – 69 ].…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of hepatitis E virus infection in animals in Africa: a systematic review and meta-analysis

et al. 2021

View full text Add to dashboard Cite

Background Hepatitis E virus (HEV) is a major cause of acute hepatitis in humans worldwide and have high burden in the resource-limited countries. Better knowledge of the epidemiology of hepatitis in animals in Africa can help to understand the epidemiology among humans. The objective of this study was to summarize the prevalence of HEV infection and distribution of HEV genotypes among animals in Africa. Methods In this systematic review and meta-analysis, we comprehensively searched PubMed, EMBASE, African Journals Online, and Africa Index Medicus from January 1st, 2000 to March 22th, 2020 without any language restriction. We considered cross-sectional studies of HEV infection in animals in Africa. Study selection, data extraction, and methodological quality of included studies were done independently by two investigators. Prevalence data were pooled using the random-effects meta-analysis. This review was registered in PROSPERO, CRD42018087684. Results Twenty-five studies (13 species and 6983 animals) were included. The prevalence (antibodies or ribonucleic acid [RNA]) of HEV infection in animals varied widely depending on biological markers of HEV infection measured: 23.4% (95% confidence interval; 12.0–37.2) for anti-HEV immunoglobulins G, 13.1% (3.1–28.3) for anti-HEV immunoglobulins M, and 1.8% (0.2–4.3) for RNA; with substantial heterogeneity. In subgroup analysis, the immunoglobulins G seroprevalence was higher among pigs 37.8% (13.9–65.4). The following HEV genotypes were reported in animals: Rat-HEV genotype 1 (rats and horses), HEV-3 (pigs), HEV-7 (dromedaries), and Bat hepeviruses (bats). Conclusions We found a high prevalence of HEV infection in animals in Africa and HEV genotypes close to that of humans. Some animals in Africa could be the reservoir of HEV, highlighting the need of molecular epidemiological studies for investigating zoonotic transmission.

show abstract

Avian hepatitis E virus is widespread among chickens in Poland and belongs to genotype 2

Cited by 13 publications

References 18 publications

Genetic Variability and Evolution of Hepatitis E Virus

Genetic Variability and Evolution of Hepatitis E Virus

Avian Hepatitis E Virus: With the Trend of Genotypes and Host Expansion

Epidemiology of hepatitis E virus infection in animals in Africa: a systematic review and meta-analysis

Contact Info

Product

Resources

About