Avian and mammalian vitamin D-dependent calcium binding protein in reptilian nephron

Rhoten, William B.; Lubit, Beverly W.; Christakos, Sylvia

doi:10.1016/0016-6480(84)90133-3

Cited by 25 publications

(12 citation statements)

References 14 publications

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“…These results represent a more extensive distribution of calbindin-D28k than tat found in the kidneys of any other animals investigated previously (Rhoten and Christakos, 1981;Taylor et al,1982;Schreiner et al, 1983;Rhoten et al, 1984) including the human (Roth et al, 1982). This statement is not strictly true as Rhoten et al (1982) reported immunoreactive calbindin-D28k in the medulla, including the ascending thick limb of the loop of Henle, as well as cortical labyrinth in neonatal rat kidney.…”

Section: Discussionmentioning

confidence: 67%

“…This group of proteins contain the common calcium ion binding motif known as EF-hand domain (Kretsinger et al, 1982). Calbindin-D28k has been reported in various species (Wasserman and Taylor, 1971;Fulmer and Wasserman, 1975;Rhoten et al, 1984Rhoten et al, , 1986 and in many tissues, including kidney (Hermsdorf and Bronner, 1975;Rhoten and Christakos, 1981;Rhoten et al, 1985), bone (Christakos and Norman, 1978), pancreas (Pochet et al, 1987), and the brain (Baimbridge et al, 1982;Feldman and Christakos, 1983).…”

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confidence: 99%

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Immunohistochemical determination of calbindin-d28k in the kidney of postnatal rats

Timurkaan¹,

Tarakçi²

2004

Vet. Med. - Czech

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ABSTRACT:The localization of calbindin-D28k was examined in rat kidney at different stages of development. Calbindin was found specifically in the distal convoluted tubules (DCT). In the 10 day old rat kidney many cells apparently belonging to the collecting tubules were positive. In the neonatal nephrons there was also localization of calbindin-D28k to the limb of Henle, suggesting a difference in the regulation of intracellular calcium during maturation. Proximal tubule, renal corpuscle and macula densa gave no specific localization of calbindin-D28k.

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Section: Discussionmentioning

confidence: 67%

mentioning

confidence: 99%

Immunohistochemical determination of calbindin-d28k in the kidney of postnatal rats

Timurkaan¹,

Tarakçi²

2004

Vet. Med. - Czech

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“…This distribution of calbindin-D28k has been described in the chicken, rat, rabbit and man kidney with only very li�le variation (Roth et al,1982;Taylor et al, 1982;Christakos et al, 1997). In addition calbindinD28k has been detected in the distal tubules of the reptilian nephron, including saurian, ophidian, and testudine kidneys (Rhoten et al, 1984;Parmentier et al, 1987).…”

mentioning

confidence: 62%

“…Calbindin-D28k was most evident in the distal convoluted tubule of the kidney in amphibia (Rhoten et al,1986;Parmentier et al, 1987), in reptilian (Rhoten et al, 1984), chicken (Roth et al, 1981;Christakos et al, 1981;Taylor et al, 1982), rabbit (Taylor et al, 1982), rat (Taylor et al, 1982;Rhoten and Christakos, 1981;Roth et al, 1982), mouse (Rhoten et al, 1985), and human (Roth et al, 1982).…”

Section: Resultsmentioning

confidence: 98%

Immunohistochemical localization of calbindin-D28k in the kidney and cerebellum of the porcupines (Hystrix cristata)

Timurkaan¹,

Aydin²,

Kaban³

2003

Vet. Med. - Czech

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ABSTRACT:The localization of calbindin in the kidney and cerebellum of Hystrix cristata was investigated immunohistochemically using an antiserum against the 28k Da calbindin of chicken duodenum. Calbindin-D28k is an intracellular protein with a high affinity for calcium. This protein is exclusively localized in the distal convoluted tubules of the kidney and in Purkinje cells of the cerebellum. Functionaly, calbindin-D28k is supposed to be involved in the regulation of the reabsorption of calcium in the distal nephron, though the exact regulatory mechanisms are not yet known.

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“…Twenty tadpoles and fif teen adults were used for immunocytochemistry and twelve adults for biochemical studies. Purified rat renal CaBP was used to prepare rabbit anti-rat renal CaBP, as described previously [Rhoten et al, 1984], Rat renal CaBP an tiserum was previously shown to cross-react with immunoidentity with extracts of rat and human brain Sonnenberg et al, 1984).…”

Section: Animalsmentioning

confidence: 99%

Immunocytochemical Localization and Immunological Characterization of Vitamin D-Dependent Calcium-Binding Protein in the Bullfrog Cerebellum

Gona¹,

Pendurthi²,

Al‐Rabiai³

et al. 1986

Brain Behav Evol

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Antiserum prepared against rat renal calcium-binding protein (CaBP) was used with the unlabeled antibody peroxidase-antiperoxidase (PAP) technique to localize the 28,000 molecular weight CaBP in the cerebellum of the bullfrog, Rana catesbeiana. Whole brains of premetamorphic tadpoles and adults were fixed in Bouin's solution for 2 or 24 h and embedded in paraffin. 8-µm parasagittal sections were prepared and treated by the PAP method. Purkinje cells of the cerebellum in tadpoles and adults were specifically stained for CaBP. In the premetamorphic corpus cerebelli, the stained Purkinje cells corresponded to the precociously developed Purkinje cells described previously. In the auricular lobe region of the cerebellum mature Purkinje cells were stained. In addition, smaller stained cells were seen. The latter were presumed to be immature Purkinje cells that would mature at the time of metamorphosis. Immunoblot procedure demonstrated cross-reactivity for the ranid brains in the 28,000 molecular weight region. This immunoreactive band comigrated with the immunoreactive band observed with purified rat renal CaBP. Although the exact functional significance of CaBP is unknown at this time, our immunocytochemical and immunological findings indicate that CaBP is an excellent marker for studies of Purkinje cell maturation.

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Avian and mammalian vitamin D-dependent calcium binding protein in reptilian nephron

Cited by 25 publications

References 14 publications

Immunohistochemical determination of calbindin-d28k in the kidney of postnatal rats

Immunohistochemical determination of calbindin-d28k in the kidney of postnatal rats

Immunohistochemical localization of calbindin-D28k in the kidney and cerebellum of the porcupines (Hystrix cristata)

Immunocytochemical Localization and Immunological Characterization of Vitamin D-Dependent Calcium-Binding Protein in the Bullfrog Cerebellum

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