Avermectins inhibit multidrug resistance of tumor cells

Korystov, Yuri N.; Ermakova, N V; Kublik, L. N.; Levitman, M. Kh.; Shaposhnikova, V. V.; Mosin, V A; Drinyaev, Viktor A.; Kruglyak, E. B.; Novik, T. S.; Sterlina, Tatiana S.

doi:10.1016/j.ejphar.2004.03.067

Cited by 54 publications

(32 citation statements)

References 15 publications

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“…The doses of abamectin ranging from 5 to 20 μmolL -1 were all inhibitory to FG cell proliferation as could be seen from the cell growth curve. It was in accord with the report that 3 μmolL -1 abamectin decreased the survival of tumor cell Hep-2 to 84 %± 2% after 2 d incubation (Kory- (Korystov et al, 2004). The results presented here show that FG cells are sensitive to abamectin, and FG cell line is suitable for the evaluation of the acute toxicity of abamectin.…”

Section: Discussionsupporting

confidence: 95%

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In vitro acute cytotoxicity of abamectin to the Gill Cell Line of Flounder Paralichthy olivaceus

Guo

Xiao

et al. 2007

J Ocean Univ. China

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The cytotoxicity of abamectin to the Gill Cell Line of Flounder (FG cell line) was examined in this study. It was found that the exposure of FG cells to abamectin caused the decreases of both cell growth rate and antioxidant enzyme activities，and the increase of intracellular O 2 -content. It was proposed that the reduction of antioxidant enzyme activities in FG cells caused the accumulation of O 2 -content in FG cells, leading to the change of cell morphology and even the death of cells. The results showed that FG cell line is suitable for the evaluation of the acute toxicity of abamectin.

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Section: Discussionsupporting

confidence: 95%

“…In addition, abamectin has also been used as an anthelmintic agent in animals and humans (Kaplan et al, 1994). Recently, Korystov et al (2004) proved that abamectin could inhibit multidrug resistance of tumor cells and may be used in tumor therapy together with some antitumor preparations.…”

Section: Introductionmentioning

confidence: 99%

In vitro acute cytotoxicity of abamectin to the Gill Cell Line of Flounder Paralichthy olivaceus

Guo

Xiao

et al. 2007

J Ocean Univ. China

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“…These factors might have predisposed TVT There are several mechanisms by which tumor cells acquire drug resistance. In dogs with TVT, overexpression of permeability glycoprotein (P-gp) is one of the major factors leading to multidrug resistance (MDR) (9,10). MDR may occur with vincristine, vinblastine, doxorubicin, prednisolone, and others (11).…”

Section: Discussionmentioning

confidence: 99%

Treatment of canine transmissible venereal tumor using L-asparaginase, prednisone, and surgery in a clinical chemotherapy-resistant case

Silva¹,

Reusing²,

Franciosi³

et al. 2014

Turk J Vet Anim Sci

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“…Recently, Korystov and coworkers [2004] demonstrated that Abamectin effectively inhibits multidrug resistance of Hep-2 and P388 tumor cells. Accordingly, the possibility of using Abamectin among other Avermectins in antitumor chemotherapy to abolish multidrug resistance of tumor cells as well as their use in combination with antitumor agents to enhance their effectiveness have been suggested [Korystov et al, 2004]. Furthermore, the effect of Abamectin on the proliferation growth of murine ascities Ehrlich carcinoma and P388 lympholeukemia, and solid Ehrlich and 755 carcinoma tumor cells was studied and the results clearly demonstrated that Abamectin is able to exert a pronounced antitumor activity, at least in mice [Drinyaev et al, 2004].…”

Section: Ivermectin and Abamectinmentioning

confidence: 99%

New Ventures in the Genotoxic and Cytotoxic Effects of Macrocyclic Lactones, Abamectin and Ivermectin

Molinari

Soloneski

Larramendy³

2010

Cytogenet Genome Res

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Abamectin and Ivermectin are 2 closely related members of the Avermectin family of 16-membered macrocyclic lactones derived from the actinomycete Streptomyces avermectinius which exhibit extraordinary anthelmintic activity. They are used worldwide in veterinary and human medicine as well as in agriculture. In the present review we summarized the results published so far for estimating the genotoxicity and cytotoxicity exerted by both compounds in several cellular systems. Although both compounds do not induce in vitro and in vivo gene mutations in either bacterial or mammalian cells, there is no concrete evidence of a clear clastogenic effect exerted both in vitro and in vivo in mammalian cells. However, reports indicating that both anthelmintic agents are able to induce single DNA-strand breaks in vitro and inhibit cell growth either in vitro or in in vivo bioassays, are scarce. Taking into account the similarity of the genotoxicity and cytotoxicity exerted by both antibiotics, and that only Abamectin has been classified so far as a class II toxicity pesticide by the EPA, the necessity of reconsideration for a further hazard evaluation of Ivermectin by an international regulatory agency(ies) is strongly recommended.

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Avermectins inhibit multidrug resistance of tumor cells

Cited by 54 publications

References 15 publications

In vitro acute cytotoxicity of abamectin to the Gill Cell Line of Flounder Paralichthy olivaceus

In vitro acute cytotoxicity of abamectin to the Gill Cell Line of Flounder Paralichthy olivaceus

Treatment of canine transmissible venereal tumor using L-asparaginase, prednisone, and surgery in a clinical chemotherapy-resistant case

New Ventures in the Genotoxic and Cytotoxic Effects of Macrocyclic Lactones, Abamectin and Ivermectin

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