Avances en mecánica computacional para el diagnóstico y tratamiento de la enfermedad cardiovascular

Álamo, Juan C. del; Marsden, Alison L.; Lasheras, Juan C.

doi:10.1016/s0300-8932(09)71692-6

Cited by 14 publications

(2 citation statements)

References 179 publications

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“…As the field of computational medicine has continued to mature, myriad computational models have arisen to investigate complex processes in health and disease. Computational vascular mechanics continues to garner particular attention as evidence mounts that disease progression is often influenced strongly by the effects of the local mechanical environment on the resident cells [1,2]. Yet, most biomechanical models have used classical mechanics, with conserved mass and unchanging material properties, despite living systems being dynamic and highly adaptable [3,4].…”

Section: Introductionmentioning

confidence: 99%

Parametric study of effects of collagen turnover on the natural history of abdominal aortic aneurysms

2013

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Abdominal aortic aneurysms (AAAs) are characterized by significant changes in the architecture of the aortic wall, notably, loss of functional elastin and smooth muscle. Because collagen is the principal remaining load-bearing constituent of the aneurysmal wall, its turnover must play a fundamental role in the natural history of the lesion. Nevertheless, detailed investigations of the effects of different aspects of collagen turnover on AAA development are lacking. A finite-element membrane model of the growth and remodelling of idealized AAAs was thus used to investigate parametrically four of the primary aspects of collagen turnover: rates of production, half-life, deposition stretch (prestretch) and material stiffness. The predicted rates of aneurysmal expansion and spatio-temporal changes in wall thickness, biaxial stresses and maximum collagen fibre stretch at the apex of the lesion depended strongly on all four factors, as did the predicted clinical endpoints (i.e. arrest, progressive expansion or rupture). Collagen turnover also affected the axial expansion, largely due to mechanical changes within the shoulder region of the lesion. We submit, therefore, that assessment of rupture risk could be improved by future experiments that delineate and quantify different aspects of patient-specific collagen turnover and that such understanding could lead to new targeted therapeutics.

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Section: Introductionmentioning

confidence: 99%

Parametric study of effects of collagen turnover on the natural history of abdominal aortic aneurysms

2013

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“…Diagnosis and treatment of heart failure is limited by the difficult acquisition of noninvasive quantitative indices of cardiac physiology. The study of velocity vectors, movable geometry, pressure-volume loops, left ventricular elastic wall stress-strain relationships, the importance of the vortex and its role as mechanical energy storage, together with the dependence of its properties, can provide accurate information for therapeutic decision-making, follow-up and prognosis [10].…”

Section: Consequence Of Vortex In Dilated Cardiomyopathymentioning

confidence: 99%

Untitled

2021

ACR

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The role of the vortex in cardiac remodeling should be understood as an etiopathogenic factor in the myocardial wall with its consequent dilation and not as a cause of this wall's alteration. It is not necessary to consider the random molecular behavior in the intraventricular vortex as maximum unpredictability. Randomness becomes uniformity. For example, in a balloon, particles move in all directions but exert the same pressure. This is analogous to the left ventricle: molecules collide against each other as a dense and anarchic crowd. A fluid applies pressure on the surface with which it makes contact, but if the chaotic elements become ordered, we have regularity. A milliliter of blood contains around one hundred trillion particles. It is impossible to combine their equations. Probability in statistics was used to find regularity in global and average behavior. The random state of molecular chaos (turbulence) that occurs in the intraventricular vortex alters the wall. Remodeling leading to volume overload starts when 20% of the ventricular mass is compromised. With increased volume there is more sphericity and vice versa. Thus, fluid becomes a sculptor of the ventricular wall through the velocity of fluid particles colliding against its walls.

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On-X Heart Valve Prosthesis: Numerical Simulation of Hemodynamic Performance in Accelerating Systole

Mirkhani

Davoudi

Hanafizadeh

et al. 2016

Cardiovasc Eng Tech

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Numerical simulation of the bileaflet mechanical heart valves (BMHVs) has been of interest for many researchers due to its capability of predicting hemodynamic performance. A lot of studies have tried to simulate this three-dimensional complex flow in order to analyze the effect of different valve designs on the blood flow pattern. However, simplified models and prescribed motion for the leaflets were utilized. In this paper, transient complex blood flow in the location of ascending aorta has been investigated in a realistic model by fully coupled simulation. Geometry model for the aorta and the replaced valve is constructed based on the medical images and extracted point clouds. A 23-mm On-X Medical BMHV as the new generation design has been selected for the flow field analysis. The two-way coupling simulation is conducted throughout the accelerating phase in order to obtain valve dynamics in the opening process. The complex flow field in the hinge recess is captured precisely for all leaflet positions and recirculating zones and elevated shear stress areas have been observed. Results indicate that On-X valve yields relatively less transvalvular pressure gradient which would lower cardiac external work. Furthermore, converging inlet leads to a more uniform flow and consequently less turbulent eddies. However, the leaflets cannot open fully due to middle diffuser-shaped orifice. In addition, asymmetric butterfly-shaped hinge design and converging orifice leads to better hemodynamic performance. With the help of two-way fluid solid interaction simulation, leaflet angle follows the experimental trends more precisely rather than the prescribed motion in previous 3D simulations.

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Avances en mecánica computacional para el diagnóstico y tratamiento de la enfermedad cardiovascular

Cited by 14 publications

References 179 publications

Parametric study of effects of collagen turnover on the natural history of abdominal aortic aneurysms

Parametric study of effects of collagen turnover on the natural history of abdominal aortic aneurysms

Untitled

On-X Heart Valve Prosthesis: Numerical Simulation of Hemodynamic Performance in Accelerating Systole

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