Avaliação do tratamento da sepse com glutamina via enteral em ratos

Fabiani, Isadora Moscardini; Rocha, Sérgio Luiz

doi:10.1590/0100-69912017003002

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…Groups that did not receive the additional nutritional contribution did not have great attenuation on the damage caused to the small intestine mucosa. Fabiani e Rocha 8 , by supplementing rats with Gln via enteral for 48 h before the induction of sepsis, observed that there was lower ischemic damage in the small intestine of this animals comparing them to the non-supplemented group. In this study we identified that the intestinal epithelium of the Gln supplemented rats presented lower desquamation and the lamina propria got lower inflammation, in comparison to the control group 7 , 8 .…”

Section: Discussionmentioning

confidence: 79%

Effects of Intraperitoneal Glutamine in the Treatment of Experimental Sepsis

Stonoga

Bueno

Nagano

et al. 2019

ABCD, arq. bras. cir. dig.

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Background: Sepsis is an important public health issue and is associated with high treatment costs and high mortality rates. Glutamine supplementation has proven to be beneficial to the functions of the immune system, acting beneficially in the evolution of patients in severe catabolic states. Aim: To evaluate the effect of glutamine supplementation via intraperitoneal in rats, induced sepsis, considering the following organs: intestines, liver, kidneys and lungs. Methods: Male Wistar rats subjected to sepsis by ligature and cecal puncture were divided into two groups: control C (n=6) and glutamine G (n=11), in which were administered dipeptiven 20% at a dose of 2 ml/kg/day (equivalent to 0.4g N(2)-L-alanyl-L-glutamine/kg) intraperitoneally 48 h prior to sepsis induction. After 48 h they were euthanized and intestine, liver, lung and kidney were removed for histological analysis. Results: Intestinal epithelial desquamation of the control group was more intense compared to the glutamine group (p=0.008). In the kidneys, degenerative tubular epithelial changes were less severe in the animals that received glutamine (p=0.029). Regarding to the liver, glutamine group showed lower levels of cell swelling than the control group (p=0.034). In the lung there were no results with statistical significance. Conclusion: Prior intraperitoneal supplementation with glutamine in experimental animals is able to reduce the damage to the intestinal mucosa, to the kidneys and liver’s histoarchitecture.

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Section: Discussionmentioning

confidence: 79%

Effects of Intraperitoneal Glutamine in the Treatment of Experimental Sepsis

Stonoga

Bueno

Nagano

et al. 2019

ABCD, arq. bras. cir. dig.

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“…There are multiple reports showing the benefits of glutamine therapy for sepsis. For example, Fabiani and Rocha [15] reported therapeutic effects of enteral glutamine against sepsis induced in rats. Bakir et al.…”

Section: Introductionmentioning

confidence: 99%

“…r Reduced ROS level. example, Fabiani and Rocha [15] reported therapeutic effects of enteral glutamine against sepsis induced in rats. Bakir et al [16] reported that combined supplementation with glutamine and arginine was very effective against lipopolysaccharideinduced sepsis.…”

Section: Introductionmentioning

confidence: 99%

Glutamine alleviates the renal dysfunction associated with gentamicin‐induced acute kidney injury in Sprague–Dawley rats

Zhan

Wang

Zhang

et al. 2021

Biotech and App Biochem

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Sepsis is a clinical condition caused by an uncontrolled response to an infection, leading to acute kidney injury (AKI) and an increased risk of mortality. Although life support and antibiotic therapy are available, the mortality rate remains high in patients with sepsis. The present study investigated the therapeutic effect of glutamine on gentamicin-induced acute kidney injury in Sprague-Dawley rats. We randomly grouped 24 male rats to the normal control, AKI (control), glutamine 50 mg/kg, and glutamine 500 mg/kg groups. The dose was administered orally for 14 consecutive days. Rats treated with glutamine 500 mg/kg showed changes in systolic blood pressure. Glutamine increased renal blood flow, creatinine clearance, and the levels of potassium, creatinine, blood urea nitrogen, and urine osmolality, while reducing the relative excretion of sodium, potassium, urinary sodium, and plasma blood urea nitrogen and creatinine levels. In our study, glutamine supplementation reduced gentamicin-induced oxidative stress and increased catalase, superoxide dismutase, glutathione peroxidase, and glutathione levels in AKI rats. In addition, glutamine supplementation attenuated the severity of pathological features in this model. Collectively, our results showed that gentamicin has therapeutic potential against gentamicin-induced AKI due to its ability to mitigate the effects of oxidative stress.

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Atuação do enfermeiro na prevenção e identificação de sinais e sintomas de sepse em terapia intensiva: uma revisão integrativa

Silva

Lima

Silva

2020

RSD

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A sepse é uma resposta inflamatória sistêmica provocada por uma infecção, podendo evoluir para sepse grave, choque séptico e morte. Objetivou-se identificar as evidências científicas quanto à atuação do enfermeiro na prevenção e identificação de sinais e sintomas de sepse em terapia intensiva. Trata-se de uma revisão integrativa de abordagem qualitativa realizada no mês de setembro, nas bases de dados MEDLINE, BDENF, LILACS e IBECS, através da Biblioteca Virtual em Saúde (BVS), foram incluídos artigos nos idiomas inglês, espanhol e português, no período de 2010 a 2020, selecionando-se 10 artigos por meio de leitura exploratória e crítica dos títulos, resumos e resultados alcançados nos estudos. Dos artigos selecionados, 70% (N=7) foram encontrados na MEDLINE, 10% (N=1) no LILACS, 20% (N=2) BDENF/LILACS. Observou-se que a quantidade de trabalhos publicados foi maior nos anos de 2010, 2011, 2017 e 2019 com dois artigos nos respectivos anos, seguidos dos anos de 2015 e 2020, com um estudo cada ano. Dentre os artigos, 90% (N=9) foram publicados na língua inglesa e 10% (N=1) na língua portuguesa. De acordo com as sínteses dos estudos analisados, observa-se que a participação da enfermagem se inicia no momento de sensibilização junto às equipes de saúde, na criação de métodos para identificar a sepse, além da identificação da importância dos pacotes e ferramentas de triagem conduzida pela enfermagem. Além disso, faz-se necessário que os enfermeiros busquem ter noções básicas das alterações sistêmicas causadas pela sepse, sejam elas relacionada às alterações hemodinâmicas, neurológicas, respiratórias, renais e nutricionais.

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Avaliação do tratamento da sepse com glutamina via enteral em ratos

Cited by 3 publications

References 15 publications

Effects of Intraperitoneal Glutamine in the Treatment of Experimental Sepsis

Effects of Intraperitoneal Glutamine in the Treatment of Experimental Sepsis

Glutamine alleviates the renal dysfunction associated with gentamicin‐induced acute kidney injury in Sprague–Dawley rats

Atuação do enfermeiro na prevenção e identificação de sinais e sintomas de sepse em terapia intensiva: uma revisão integrativa

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