Avaliação da atividade antibacteriana do óleo da microalga Chlorella minutissima como alternativa para o tratamento de dermatite atópica

Abstract

Atopic dermatitis is an inflammatory skin disease that may be chronic and recurrent. Staphylococcus aureus infection is the most common cause of the disease due to toxin production by this bacterium. Antibiotic use is increasing over the years, and their indiscriminate use is linked to bacterial resistance. Therefore, the development of effective alternatives to the practice of antibiotic use is essential for infection control. From this perspective, the objective of this research was to cultivate the microalgae Chlorella minutissima under batch regime, to evaluate the chlorophyll production and the antimicrobial activity of the microalgal oil on the S. aureus microorganism. The microalgae was cultivated for 33 days under constant light and aeration, with temperatures ranging from 21 ° C to 33 ° C. At the end of this period, the crop was flocculated and vacuum filtered to obtain dry biomass. The oil was obtained by the hot extraction method and its antimicrobial activity against Staphylococcus aureus bacteria was evaluated. As a result, the microalgae grew during the first 15 days of cultivation, when it entered the stationary phase. However, it achieved higher chlorophyll production on the 18th day of cultivation. The oil and extracts obtained from microalgae had a positive effect on growth inhibition of Staphylococcus aureus. Thus, although in-depth studies are required, the results suggest that bioproducts extracted from Chlorella minutissima microalgae are promising for the treatment of atopic dermatitis.

Abordagens no tratamento da dermatite atópica

“…A proliferação epidérmica por Staphylococcus aureus tem uma vasta relação com a gravidade da ''Dermatite Atópica''. Na presença de comprovação médica de uma infecção secundária, recomenda-se o uso de antissépticos tópicos, assim como antibióticos tópicos, mesmo que seu movimento necessite de pesquisa adicional (da Rocha Simões et al, 2019).…”