Availability of calcium from skim milk, calcium sulfate and calcium carbonate for bone mineralization in pigs

Abstract

-Dairy products provide abundant, accessible calcium for humans, while some calcium sulfate-rich mineral waters could provide appreciable amounts of calcium. But there is little evidence that this calcium is as available as milk calcium for making bone. The availability of calcium was studied by monitoring bone parameters in 2-month-old pigs fed restricted amounts of calcium (70% RDA) for 2.5 months. The 3 main (≥ 50% Ca intake) Ca sources were either CaCO 3 or CaSO 4 or skim milk powder (29% of the diet). The bones of the pigs fed the "milk" diet had higher (P < 0.01) ash contents, breaking strength and density (DEXA) than those of the two others groups, in which the bone values were similar. Thus, the calcium provided by a diet containing milk appears to ensure better bone mineralization than do calcium salts included in a non-milk diet. The calcium restriction may have enhanced some milk properties to stimulate calcium absorption in these young, rapidly growing pigs.calcium availability / calcium sulfate / milk calcium / bones / pigs Résumé -Biodisponibilité comparée du calcium du lait, du sulfate et du carbonate de calcium pour la minéralisation osseuse: étude chez le porc. Le sulfate de calcium, dont certaines eaux minérales sont riches, est-il aussi bien utilisé pour la minéralisation osseuse que le calcium des produits laitiers ? Trois lots de 8 porcs, de 2 mois, recevaient pendant 2,5 mois, trois régimes dont au moins 50 % de l'apport calcique était fourni par CaSO 4 , CaCO 3 ou la poudre de lait. Bien que différents dans leur composition, les trois régimes étaient formulés pour avoir la même valeur nutritionnelle et leur teneur en Ca était restreinte (70 % des recommandations). Avec le régime « lait », les cendres, la résistance à la rupture et la densité minérale des os étaient supérieures à celles des deux autres groupes, non différents l'un de l'autre. L'analyse des paramètres circulants liés au métabolisme osseux (en particulier au collagène), des 3 groupes, exclut l'hypothèse d'un effet direct de la source Reprod. Nutr. Dev. 40 (2000) 49-61 49

Dairy Versus Calcium Carbonate in Promoting Peak Bone Mass and Bone Maintenance During Subsequent Calcium Deficiency

“…One other animal study did report a significant advantage of a milk‐based diet. Pointillart et al (31) created a situation of restricted (two‐thirds requirement) calcium intake during increased skeletal demand in young male pigs and found that a milk diet resulted in significantly greater BMD and breaking strength compared with two other sources of restricted calcium (calcium sulphate and carbonate). Only one study has directly compared a dairy product with calcium carbonate for bone accrual in children (6) .…”

Dietary isoflavones act on bone marrow osteoprogenitor cells and stimulate ovary development before influencing bone mass in pre‐pubertal piglets

“…The 40‐day‐old piglets weighed 8 kg at the beginning of the experiment. All animals were fed the same amounts of a diet formulated to meet the requirement for growing pigs (Pointillart et al, 2000), providing 13.8 MJ of digestible energy/kg, 1.1% calcium, and 0.8% phosphorus. This diet consisted of (% of diet) 54.5 wheat, 29.3 barley, 13.3 soluble fish (solubilized fish protein concentrate, CPSP 90, Sopropêche, Boulogne/Mer, France), and 2.9 vitamin–mineral mixture.…”

The Pig as an Experimental Model for Elucidating the Mechanisms Governing Dietary Influence on Mineral Absorption

“…Many of these studies, in addition to others, have also highlighted the critical importance of the chemical form of fortificant utilized in the treatment of mineral deficiencies, as the bioavailability of these different chemical forms can be significantly different. For instance, Pointillart et al (31) used a pig model to analyze bone calcium content so as to compare calcium bioavailability from milk and supplemental calcium salts. They detected significantly higher bone calcium content in pigs administered milk, as compared to the groups administered supplemental calcium salts, given as either calcium carbonate or calcium sulfate.…”