The Pig as an Experimental Model for Elucidating the Mechanisms Governing Dietary Influence on Mineral Absorption

Patterson, Jannine K.; Lei, Xin Gen; Miller, Dennis D.

doi:10.3181/0709-mr-262

Cited by 219 publications

(186 citation statements)

References 126 publications

(181 reference statements)

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“…The small intestine of adult pig is around 15-22 m, whereas the large intestine has an average length of 4-6 m. In contrast, the small intestine of a human adult averages around 5.5-7 m, whereas the large intestine is around 1.5 m. In spite of these differences, the porcine digestive and metabolic processes function in much the same way as those of humans, and digest transit times are also similar between the two species. The intestinal villus structure and component epithelial cells are also very much alike, which makes pigs an ideal model for human nutritional studies to investigate bioavailability and digestibility of various dietary factors in gastrointestinal compartments (Patterson et al 2008).…”

Section: Micronutrient Bioavailabilitymentioning

confidence: 99%

Nutritionally Enhanced Staple Food Crops

Dwivedi

Sahrawat

Kedar

et al. 2012

Plant Breeding Reviews

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Section: Micronutrient Bioavailabilitymentioning

confidence: 99%

Nutritionally Enhanced Staple Food Crops

Dwivedi

Sahrawat

Kedar

et al. 2012

Plant Breeding Reviews

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“…The anatomic (stomach to cecum) and histologic structure of the pig intestine as well as the physiologic and immunologic functions of the intestine are similar to humans. Pigs produce similar digestive enzymes, transport and secretory proteins, and their capacity to absorb water and nutrients are comparable with people (Patterson, Lei, & Miller, 2008;Zhang, Widmer, & Tzipori, 2013). Pigs also have high numbers of plasma and intraepithelial γδ T cells, and they are an excellent model to examine the effects γδ T cells on the induction of IBD (Kazen & Adams, 2011).…”

Section: Considerations For Choosing the Most Appropriate Animal Modelmentioning

confidence: 99%

Considerations for Choosing Appropriate Animal Models to Study Inflammatory Bowel Disease

Uwiera¹,

Uwiera²,

Jiminez³

et al. 2016

JAS

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This article examines several animal models used to investigate mechanisms involved in the induction and progression of inflammatory bowel disease in people. The use of appropriate animal models to study intestinal inflammation requires careful consideration as each model has strengths and limitations for investigating disease, and no single model provides a complete understanding of the disease process. In as such, it compels researchers to carefully contemplate the advantages and disadvantages of each animal model, and to consider the process of choosing the best animal model(s) as an essential component of the experimental design.

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“…E-mail: javierdc@ugr.es A variety of experimental models have been used in studies related to iron through the time (Latunde-Dada et al, 1998;Srigiridhar and Nair, 2000;Morgan and Oates, 2002;Troost et al, 2003;Nagababu et al, 2008;Quintero et al, 2008;Jin et al, 2009;Latunde-Dada, 2009). Nevertheless, in vitro systems or animal models have different iron metabolism behaviour when compared with humans (Latunde-Dada et al, 1998;Vaghefi et al, 2005;Patterson et al, 2008;Quintero et al, 2008). Studies related to iron involve different procedures including isotopic techniques, simulated enzymatic gastrointestinal digestion or hemoglobin (Hb) depletion-repletion (Srigiridhar and Nair, 2000;Beach et al, 2003;Vaghefi et al, 2005;Kolachala et al, 2007;Quintero et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Advantages and disadvantages of the animal models v. in vitro studies in iron metabolism: a review

García¹,

Díaz-Castro

2013

Animal

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Iron deficiency is the most common nutritional deficiency in the world. Special molecules have evolved for iron acquisition, transport and storage in soluble, nontoxic forms. Studies about the effects of iron on health are focused on iron metabolism or nutrition to prevent or treat iron deficiency and anemia. These studies are focused in two main aspects: (1) basic studies to elucidate iron metabolism and (2) nutritional studies to evaluate the efficacy of iron supplementation to prevent or treat iron deficiency and anemia. This paper reviews the advantages and disadvantages of the experimental models commonly used as well as the methods that are more used in studies related to iron. In vitro studies have used different parts of the gut. In vivo studies are done in humans and animals such as mice, rats, pigs and monkeys. Iron metabolism is a complex process that includes interactions at the systemic level. In vitro studies, despite physiological differences to humans, are useful to increase knowledge related to this essential micronutrient. Isotopic techniques are the most recommended in studies related to iron, but their high cost and required logistic, making them difficult to use. The depletion--repletion of hemoglobin is a method commonly used in animal studies. Three depletion--repletion techniques are mostly used: hemoglobin regeneration efficiency, relative biological values (RBV) and metabolic balance, which are official methods of the association of official analytical chemists. These techniques are well-validated to be used as studies related to iron and their results can be extrapolated to humans. Knowledge about the main advantages and disadvantages of the in vitro and animal models, and methods used in these studies, could increase confidence of researchers in the experimental results with less costs.

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The Pig as an Experimental Model for Elucidating the Mechanisms Governing Dietary Influence on Mineral Absorption

Abstract: This review highlights the similarities between pigs and humans and thereby the value of the porcine human nutritional model, and reviews some of the more recent applications of this model for nutritional research.

Cited by 219 publications

References 126 publications

Nutritionally Enhanced Staple Food Crops

Nutritionally Enhanced Staple Food Crops

Considerations for Choosing Appropriate Animal Models to Study Inflammatory Bowel Disease

Advantages and disadvantages of the animal models v. in vitro studies in iron metabolism: a review

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