Autologous Cultured Melanocytes in Vitiligo Treatment

Czajkowski, Rafał; Placek, Waldemar; Drewa, Tomasz; Kowaliszyn, Bogna; Sir, Jan; Weiss, Wioletta

doi:10.1097/00042728-200709000-00002

Cited by 18 publications

(28 citation statements)

References 21 publications

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“…Younger patients less than 15 years showed better results in previous studies, and there was a similar trend in our study, with more than 75% repigmentation seen in the younger age group (mean age 22 years vs. 26 years).…”

Section: Discussionsupporting

confidence: 91%

Use of platelet‐rich plasma to suspend noncultured epidermal cell suspension improves repigmentation after autologous transplantation in stable vitiligo: a double‐blind randomized controlled trial

et al. 2018

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Background Noncultured epidermal cell suspension (NCES) is an effective surgical modality for stable vitiligo which involves transplantation of the basal layer of epidermal cells onto the dermabraded vitiliginous patch. Platelet-rich plasma (PRP) has growth factors which may stimulate melanocyte migration and proliferation of keratinocytes and fibroblasts. The objective of this study was to compare the extent of repigmentation achieved by transplantation of NCES suspended in PRP with that of NCES suspended in phosphate buffered saline (PBS).Methods Twenty-one patients of stable vitiligo with at least two lesions of comparable size were included. The two vitiligo patches were randomized to receive NCES suspended in PRP or PBS. Postoperatively after 1 week, patients were given heliotherapy for 15 minutes daily.Results At 6 months follow-up, mean repigmentation by area method in PRP arm was 75.6 AE 30% SD and in non-PRP arm was 65 AE 34% SD (P = 0.0036). Patient satisfaction by visual analogue scale at 6 months also showed better results in PRP arm (P = 0.001).Assessment by three independent observers showed better repigmentation in PRP side both at 3 and 6 months.Conclusions Suspending NCES in PRP can result in significantly greater mean repigmentation and patient satisfaction than suspending in PBS.

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Section: Discussionsupporting

confidence: 91%

Use of platelet‐rich plasma to suspend noncultured epidermal cell suspension improves repigmentation after autologous transplantation in stable vitiligo: a double‐blind randomized controlled trial

et al. 2018

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“…According to Czajkowski et al, 13 with increased suction time, the number of live melanocytes is decreased in the epidermis. This may be the reason why only 27% of the lesions in the SBEG group showed excellent repigmentation.…”

Section: Discussionmentioning

confidence: 98%

Comparison between autologous noncultured epidermal cell suspension and suction blister epidermal grafting in stable vitiligo: a randomized study

Budania

Parsad

Kanwar

et al. 2012

British Journal of Dermatology

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“…In this work, similar to previous studies 5,6,8,10,11 , we used a dermatome to obtain donor skin. To prepare recipient skin, we used freezing by liquid nitrogen similar to reports by Czajkowski et al 9 , which we felt was less bloody and less traumatizing to the patient. To overcome the problem of leakage of melanocyte-keratinocyte suspension from cryoblebs in recipient skin, we adapted a technique similar to that reported by Van Geel et al 6 who added hyaluronic acid to the melanocyte suspension in a 1 : 1 ratio to increase the viscosity and create a paste.…”

Section: Discussionmentioning

confidence: 99%