Autoimplantation technique in the treatment of anogenital warts: a clinico-immunological study

Usman, Najmi; Udayashankar, K; Subramanian, S; Thyagarajan, Sadras Panchatcharam

doi:10.1258/0956462961917078

Cited by 5 publications

(6 citation statements)

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“…9,10 Genital Warts are broadly divided into acuminate, flat or macular warts and keratinised wart. 11 Even though various therapeutic modalities being available, no single therapy has been found to be efficacious and cosmetically acceptable in majority of the patients. Aims of treatment for multiple, recalcitrant warts should be removal of the warts, without recurrence, without any post treatment morbidity.…”

Section: Discussionmentioning

confidence: 99%

A prospective clinical study on homologous autoinoculation in anogenital wart

Narayanan

Nallu²,

Venu³

et al. 2019

Int J Res Dermatol

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Background: Ano-genital wart, an infection of the anal and genital mucosa with their adjoining area is caused by human papilloma virus. Genital warts pose a bigger challenge, because of the lack of cell mediated immunity and its propensity to relapse and the reluctance of patients to consult a physician. The main aim of our study is to determine whether autoinoculation is effective in treatment of ano-genital warts.Methods: 25 cases of anogenital warts of either sex, who attended RTI/STI clinic in Chengalpattu Medical College from September 2017 to September 2018. The study design was prospective. A detailed history taking, thorough clinical examination and appropriate relevant investigations were done for all the patients who fulfilled the inclusion and exclusion criteria. Autoinoculation was done for those patients. They were assessed periodically for clinical outcome.Results: A sample size of 25 patients (20 men and 5 women) was included in the study. After 3 months of therapy 8 (32%) patients recovered completely and more than 75% improvement occurred in another 7 (28%) patients. At 6 months 15 (60%) patients showed complete resolution. No significant complication was documented.Conclusions: Autoinoculation is a single time minimal invasive procedure effective in management of anogenital wart. It also reduces the recurrence of lesions.

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Section: Discussionmentioning

confidence: 99%

A prospective clinical study on homologous autoinoculation in anogenital wart

Narayanan

Nallu²,

Venu³

et al. 2019

Int J Res Dermatol

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“…In 1996, Usman et al. (109) used a novel technique of auto‐implantation where anogenital wart tissue was implanted subcutaneously in the arm. This was one of the first attempts at inducing immunity against HPV.…”

Section: Less Commonly Employed Therapiesmentioning

confidence: 99%

Therapy of external anogenital warts and molluscum contagiosum: a literature review

Ting

Dytoc

2004

Dermatol Ther

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Anogenital warts and mollusca contagiosum are virally induced, benign skin tumors for which there is no single preferable therapy. Treatments include physical and chemical destruction, surgical removal, and biological response modifiers to enhance the natural immune response. The choice of therapy is an art, and depends upon patient preference, finances, number of lesions, and lesional morphology. However, the therapy of these lesions can sometimes be very painful and expensive, and therapy should not be worse than the disease.

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“…This is done by extracting a subcutis deep wart tissue and implanting it into the uninvolved skin. [34] This leads to wound at two sites and more discomfort and risks infection. The autowart injection involves multiple sessions of injection of wart suspension.…”

Section: Introductionmentioning

confidence: 99%

A novel modification of the autoimplantation therapy for the treatment of multiple, recurrent and palmoplantar warts

Nischal

Sowmya

Swaroop

et al. 2012

J Cutan Aesthet Surg

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Background:Ideal treatment for warts should be effective, safe, have less morbidity and provide long-lasting immunity against human papilloma virus. This can optimally achieved by the stimulation of the immune system against the virus. The autoimplantation of warts, autowart injection and quadrivalent vaccines have been used for this purpose. Autoimplanatation is a simple technique where the subcutis deep wart tissue is harvested as a donor and implanted into the uninvolved skin. However, this led to two wounds, at donor and recipient sites.Aim:The aim was to evaluate the safety and efficacy of a novel modification of autoimplantation therapy in the treatment of multiple, recurrent and palmoplantar warts.Subjects and Methods:Thirty-three patients with multiple, recurrent and palmoplantar warts were enrolled. Instead of taking a bit of the wart tissue, the donor tissue was harvested by paring the wart. The pared tissue was implanted deep into the subcutis by stab incision done using the same surgical blade no. 11. The resolution of all warts within 3 months after the procedure was considered successful. Patients with complete clearance were followed up for 1 month for any recurrence.Results:Out of 35 patients, 27 patients were available for follow-up. A total of 20 (74.1%) patients showed a complete clearance of warts within 3 months. Partial clearance was seen in 1 patient. Erythematous nodules developed at the site of implantation in 3 (11.1%) patients. There was relapse in one patient.Conclusion:A modified technique of autoimplantation of warts employing the pared stratum corneum tissue from the wart is a simple, effective, less traumatic and rapid procedure in the treatment of multiple, recurrent and palmoplantar warts.

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Autoimplantation technique in the treatment of anogenital warts: a clinico-immunological study

Cited by 5 publications

References 0 publications

A prospective clinical study on homologous autoinoculation in anogenital wart

A prospective clinical study on homologous autoinoculation in anogenital wart

Therapy of external anogenital warts and molluscum contagiosum: a literature review

A novel modification of the autoimplantation therapy for the treatment of multiple, recurrent and palmoplantar warts

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