A prospective clinical study on homologous autoinoculation in anogenital wart

Abstract

<p class="abstract"><strong>Background:</strong> Ano-genital wart, an infection of the anal and genital mucosa with their adjoining area is caused by human papilloma virus. Genital warts pose a bigger challenge, because of the lack of cell mediated immunity and its propensity to relapse and the reluctance of patients to consult a physician. The main aim of our study is to determine whether autoinoculation is effective in treatment of ano-genital warts.</p><p class="abstract"><strong>Methods:</strong> 25 cases of anogenital warts of either sex, who attended RTI/STI clinic in Chengalpattu Medical College from September 2017 to September 2018. The study design was prospective. A detailed history taking, thorough clinical examination and appropriate relevant investigations were done for all the patients who fulfilled the inclusion and exclusion criteria. Autoinoculation was done for those patients. They were assessed periodically for clinical outcome.<strong></strong></p><p class="abstract"><strong>Results:</strong> A sample size of 25 patients (20 men and 5 women) was included in the study. After 3 months of therapy 8 (32%) patients recovered completely and more than 75% improvement occurred in another 7 (28%) patients. At 6 months 15 (60%) patients showed complete resolution. No significant complication was documented.</p><p class="abstract"><strong>Conclusions:</strong> Autoinoculation is a single time minimal invasive procedure effective in management of anogenital wart. It also reduces the recurrence of lesions.</p>

Effectiveness of autoinoculation in viral warts: A single arm, open‐label, and clinical trial

“…Since then, four open‐labeled studies from India reported response to autoinoculation therapy in 65% to 88% of patients with verruca vulgaris within a follow‐up period of 3 to 6 months 7‐10 . Two studies of autologous implantation on genital warts showed a response rate of 60% to 70% 11,12 . In our study, complete response was seen in 65% patients.…”

“…[7][8][9][10] Two studies of autologous implantation on genital warts showed a response rate of 60% to 70%. 11,12 In our study, complete response was seen in 65% patients. Previous studies have found that periungual warts are difficult to treat/cure because of the involvement of the nail and/or nail bed leading to the possibility of deforming or damaging the nail apparatus including nail bed and matrix.…”