Autoimmune thyroid disease as a risk factor for angioedema in patients with chronic idiopathic urticaria: a case-control study

Abstract

CONTEXT AND OBJECTIVE: An association between chronic idiopathic urticaria (CIU) and autoimmune thyroid disease (ATD) has been reported. However, there have not been any reports on whether ATD raises the risk of angioedema, which is a more severe clinical presentation of CIU. Thus, the aim of the present study was to evaluate whether the risk of angioedema is increased in patients with CIU and ATD. DESIGN AND SETTING: Case-control study including 115 patients with CIU at a tertiary public institution. METHODS:The patients were evaluated with regard to occurrence of angioedema and presence of ATD, hypothyroidism or hyperthyroidism. RESULTS: Angioedema was detected in 70 patients (60.9%).

Clinical and Therapeutic Implications of the Association between Chronic Urticaria and Autoimmune Thyroiditis

“…In addition, although not statistically significant, the proportion of patients who required systemic corticotherapy for the control of urticaria exacerbations in our study was higher among those who associated autoimmune thyroiditis. Another notable difference between the two groups is the higher incidence of angioedema in the chronic urticaria associated with autoimmune thyroiditis group, (17,18) suggesting a more severe disease. The identification of this subset of patients early in the course of the disease is important and several tests, like ASST and the determination of serum anti-FcεRIα and anti-IgE antibodies, have been studied for this purpose.…”

Primjena autohemoterapije u liječenju hronične urtikarije

“…U studiji Missaka i sar. [17] kod 115 ispitanika sa urtikarijom prosječna dob je bila 36,5 godina (raspon 30-49 godina), a većina ispitanika su bile žene (79,1%). Silvares i sar.…”

Thyrotropin receptor gene expression in the association between chronic spontaneous urticaria and Hashimoto's thyroiditis

“…1,2 In most cases, the cause is unknown, thus the condition is known as chronic spontaneous urticaria (CSU). 1,6,7 There are reports of association between CSU and autoimmune thyroid disease, [8][9][10] specifically Graves disease (GD) and 1,6,7 There are reports of association between CSU and autoimmune thyroid disease, [8][9][10] specifically Graves disease (GD) and…”

“…[10][11][12] HT is the most common autoimmune thyroid disease and may evolve to primary hypothyroidism. [10][11][12] HT is the most common autoimmune thyroid disease and may evolve to primary hypothyroidism.…”