Clinical and Therapeutic Implications of the Association between Chronic Urticaria and Autoimmune Thyroiditis

Bumbăcea, Roxana Silvia

doi:10.4183/aeb.2014.595

Cited by 5 publications

(6 citation statements)

References 33 publications

(37 reference statements)

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“… 33 Since TSH has been shown to induce direct T cell, B cell, and dendritic cell activation in addition to the release of proinflammatory cytokines, which trigger an inflammatory state in the thyroid gland and other tissues including the skin. 33 In addition, treating patients with LT4 can decrease the levels of TPO-Ab and TG-Ab, while patients without LT4 substitution had a gradual increase of TPO-Ab and TG-Ab levels, as well as a tendency to gradual increase of TSH levels overtime leading to thyroid dysfunction. 34 - 36 Another effective complementary treatment for TAI is the trace element Selenium.…”

Section: Discussionmentioning

confidence: 99%

Severe subtype of alopecia areata is highly associated with thyroid autoimmunity

Saif

2016

SMJ

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Objectives:To assess the significance of thyroid autoimmune screening in alopecia areata (AA) patients in Saudi population, and to determine whether there is a difference in thyroid autoimmune susceptibility between mild and severe AA.Methods:In a prospective case-control study, we included 50 alopecia totalis (AT) and alopecia universalis (AU) patients, 50 age- and gender-matched patients with localized AA, and 50 age- and gender- matched healthy subjects between March 2015 and August 2015. Patients with AA were consecutively recruited from the hair disorders out-patient clinic of King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia.Results:Thyroid autoantibodies (TAAs) were positive in AT/AU (40%), mild AA (14%), and healthy subjects (4%). The frequency of TAAs was significantly higher in patients with AT/AU than in mild AA (p=0.001) and healthy controls (p<0.001). The frequency of thyroid peroxidase antibody (TPO-Abs) was significantly higher in patients with AT/AU than in mild AA and healthy controls (p<0.001 for both). The frequency of TG-Abs was significantly higher in patients with AT/AU (p=0.003) and mild AA (p=0.043) than in healthy controls. Serum TSH level was significantly higher in AT/AU patients than in mild AA patients (p=0.006) and healthy controls (p=0.005).Conclusion:Severe subtype of AA is associated with a high risk of autoimmune thyroid disease. This highlights the significance of screening for thyroid abnormalities and TAAs in patients with AT/AU.

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Section: Discussionmentioning

confidence: 99%

Severe subtype of alopecia areata is highly associated with thyroid autoimmunity

Saif

2016

SMJ

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“…This complex case can be classified both as PAS type III or IV, and as MAS type 3 and is highly illustrative for the concept of polyautoimmunity, which sets in relation diverse autoimmune conditions and diverse disease phenotypes with a common genotypic background (3,11,12). The coexistence of 4 autoimmune disorders has been documented in less than 25% of MAS patients(3), with SLE, AITD and vitiligo occurring the most frequently in different combinations (3,(12)(13)(14)(15). However, the coexistence of the particular four autoimmune diseases of our patient is rare.…”

Section: Discussionmentioning

confidence: 95%

Polyglandular Autoimmune Syndrome Associated with Multiple Autoimmune Conditions and Atopic Drmatitis - an Unusual Manifestation of a Polyautoimmunity Phenotype

Forsea

Mihai

Predescu³

et al. 2017

Acta Endo (Buc)

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introduction. The polyglandular autoimmune syndrome (PAS) type III is a rare condition defined as the coexistence of autoimmune thyroid disorder with other endocrine autoimmune diseases, including type 1 diabetes, without adrenal dysfunction. PAS may associate with other non-endocrine autoimmune diseases, overlapping with the multiple autoimmune syndromes (MAS). We present a case of PAS III/ MAS type 3, including autoimmune thyroiditis, autoimmune diabetes, vitiligo, lupus erythematosus, associated with adult-onset atopic dermatitis, a combination not reported previously. case report. A 40 years old woman, registered as nurse working in dialysis unit, previously diagnosed with vitiligo, euthyroid autoimmune thyroiditis and disseminated granuloma annulare, with personal and familial history of atopic disorders, presented in our clinic for disseminated eczematous and lichenoid cutaneous rashes. She was tested positive for antinuclear, anti-double stranded DNA and anti-histone antibodies, with inflammatory syndrome and marginal lymphopenia and she was diagnosed with systemic lupus erythematosus (SLE). Subsequently, moderate hyperglycemia, positive anti-glutamic acid decarboxylase antibodies and low C-peptide level prompted the diagnosis of autoimmune diabetes. Recurrent flexural eczematous rashes, with negative epicutaneous tests but positive specific IgE tests for common allergens fulfilled the clinical criteria for the diagnosis of atopic dermatitis. The clinical, immunological and glycemic status were controlled with low doses of oral prednisone (<0.5 mg/kg), methotrexate (10mg/week), antimalarials, metformin, emollients and photoprotection. After changing her workplace, the immunosuppressive treatment could be discontinued, and the patient maintained normal immunological and biochemical profile at 6 months follow-up. This case brings a unique perspective on the evolution, associations spectrum and the management challenges of endocrine polyautoimmunity associated with atopic diathesis.

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“…The association of vitiligo with autoimmune thyroid diseases and the increased prevalence of autoantibodies including thyroid autoantibodies in vitiligo had been proven by several recent studies [9][10][11] . In Sutton's nevi was usually described an inflammatory cellular infiltrate surrounding symmetrically the naevus, consisting mainly of T-lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

“…Thyroiditis is defined histologically by the presence of a diffuse lymphocytic infiltrate in the thyroid gland, with the formation of lymphoid follicles. Cell mediated and antibody mediated immune responses lead to the destruction of thyroid cells [10] . In patients with multiple HN, the risk of vitiligo and other autoimmune diseases seems to be higher than in pediatric patients with a single HN.…”

Section: Discussionmentioning

confidence: 99%

A study of Halo naevi, vitiligo and asymptomatic autoimmune thyroiditis

Tatu¹,

Clătici²,

Ionescu³

et al. 2017

IDVR

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Background Halo Naevus (HN) is a dermatologic condition characterized by a typical whitish rim arround an existing melanocytic congenital or acquired nevus, it was first described in 1916 by Sutton [1]. Halo naevi are common in children and young adults, with a mean age at onset of 15 years. The incidence in general population is estimated to be approximately 1% [2]. Affected individuals frequently have multiple lesions which are usually localized on the back. HN is an autoimmune response and T lymphocytes are considered to play a key role in the progressive destruction of naevus' cells. Multiple HN is rather rare and this could suggest a higher risk of vitiligo or of autoimmune disease development comparing to solitary HN lesion risks. The mechanism of halo phenomenon is still non completely defined and is suggested to be induced by a destruction of melanocytes by immune response of cytotoxic T cells [3] or due to IgM autoantibodies induction [4]. Purpose We sought to assess the association of Hallo Naevi (HN) or of HN-vitiligo with thyroiditis by screening markers of thyroiditis in patients presenting Hallo Naevi (HN) and HN associated with vitiligo.

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Clinical and Therapeutic Implications of the Association between Chronic Urticaria and Autoimmune Thyroiditis

Cited by 5 publications

References 33 publications

Severe subtype of alopecia areata is highly associated with thyroid autoimmunity

Severe subtype of alopecia areata is highly associated with thyroid autoimmunity

Polyglandular Autoimmune Syndrome Associated with Multiple Autoimmune Conditions and Atopic Drmatitis - an Unusual Manifestation of a Polyautoimmunity Phenotype

A study of Halo naevi, vitiligo and asymptomatic autoimmune thyroiditis

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