Autoimmune Progesterone Dermatitis

Hart, Roland J.

doi:10.1001/archderm.1977.01640040034003

Cited by 80 publications

(58 citation statements)

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“…However, clinical cases of progesteroneinduced anaphylaxis, eczema, dermatitis and urti caria in vivo and in situ [47][48][49][50] support that proges terone triggers mast cell secretion. Recent evidence suggests high-affinity binding of progesterone to rat basophilic leukemia cells [51] which are similar to mu cosal mast cells [52].…”

Section: Discussionmentioning

confidence: 99%

Progesterone Triggers Selective Mast Cell Secretion of 5-Hydroxytryptamine

Vliagoftis

Dimitriadou

Theoharides³

1990

Int Arch Allergy Immunol

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Mast cells are involved in allergic reactions where they secrete numerous mediators in response to immunoglobulin E and antigen. However, they have recently been implicated in neuroinflammatory conditions with a higher prevalence in women, and there have been clinical reports of progesterone anaphylaxis. When tested on purified rat peritoneal mast cells, progesterone alone stimulated release only of 5-hydroxy-tryptamine (serotonin) in a dose- and time-dependent manner. Serotonin release by progesterone was exceptional because it was not accompanied by histamine release or degranulation and was either augmented or unaffected by drugs which inhibit secretion induced by the classic mast cell secretagogue, compound 48/80. These findings indicate that mast cells are capable of selective serotonin secretion, previously shown only after pretreatement with certain tricyclic drugs, and may be involved in neuroendocrine syndromes.

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Section: Discussionmentioning

confidence: 99%

Progesterone Triggers Selective Mast Cell Secretion of 5-Hydroxytryptamine

Vliagoftis

Dimitriadou

Theoharides³

1990

Int Arch Allergy Immunol

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“…When associated with menstruation it can be a manifestation of autoimmune progesterone dermatitis (Hart 1977). Alternatively the link could be indirect, with the erythema multiforme being triggered by menstrual-associated herpes simplex or the use of analgesics or other drugs at the time of the menses.…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested by Hart (1977) that the synthetic progestogen may act as a stimulus for antibodies which cross-react with natural progesterone. The cyclical erythema multiforme in this patient was provoked by both endogenous and exogenous progesterone and a synthetic progesterone.…”

Section: Discussionmentioning

confidence: 99%

“…Autoimmune progesterone dermatitis (Hart 1977) is a well recognized though rare condition characterized by the recurrence of an eruption in the luteal phase of each menstrual cycle. The eruption may comprise erythema multiforme, pompholyx eczema or urticaria (Hart 1977, Georgouras 1981.…”

mentioning

confidence: 99%

“…The eruption may comprise erythema multiforme, pompholyx eczema or urticaria (Hart 1977, Georgouras 1981. The patient reported here had cyclical erythema multiforme and is the first case in which the initiation of the eruption has been demonstrated to correspond to the postovulation rise in serum progesterone.…”

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confidence: 99%

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