Progesterone-Induced Erythema Multiforme

Autoimmune progesterone dermatitis: clinical presentation and management with progesterone desensitization for successful in vitro fertilization

“…Skin lesions include urticaria, angioedema, erythema multiforme, eczema, folliculitis, papulovesicular eruptions, fixed drug eruption, purpura, or vulvovaginal pruritus (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Anaphylaxis is also reported (21)(22)(23).…”

Sex hormones and urticaria

“…Antihistamine therapy proved unsuccessful and high doses of corticoids administered prior to and during menses may only occasionally improve the symptoms [39]. In some cases, conjugated estrogen [34,40] or the anti-estrogen drug Tamoxifen [36,41,38] ensure effective treatment. Buserelin, a gonadotrophinreleasing hormone analogue, may be helpful in management of progesterone-induced urticaria whenever conjugated estrogens are contraindicated or unhelpful [42].…”

Drug-Induced Urticaria and Angioedema: Pathomechanisms and Frequencies in a Developing Country and in Developed Countries

“…However, urticaria related to the menstrual cycle may be due to an autoimmune reaction to endogenous progesterone and is a component of a spectrum of reactions ranging from erythema multiforme [47]to eczema [48]. Urinary progesterone can, interestingly, also cause contact urticaria in laboratory personnel handling adult female (but not male) mice [Greaves, unpubl.…”