Sex hormones and urticaria

Kasperska−Zając, Alicja; Brzoza, Zenon; Rogala, Barbara

doi:10.1016/j.jdermsci.2008.04.002

Cited by 63 publications

(55 citation statements)

References 61 publications

(89 reference statements)

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“…Ayrıca hipotalamo-hipofizer aks üzerinden ovülasyonu baskılayarak postovulatuar progesteron salınımını engelleyebileceği bildirilmiştir. Tamoksifen bu bağlamda çok etkilidir; ancak venöz tromboz oluşumu, katarakt gelişimi gibi yan etkileri kullanımını kısıtlar (7). Tedavide diğer bir seçenek GnRH analoglarıdır.…”

Section: Discussionunclassified

Autoimmune Progesterone Dermatitis: Two Case Reports

Benar¹,

Cemil²,

Atay³

et al. 2018

tdd

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Otoimmün progesteron dermatiti, nadir görülen ve endojen progesterona karşı gelişen bir hipersensitivite reaksiyonudur. Döngüsel olarak menstrüel siklusun luteal fazında başlayıp, menstrüel kanamanın başlamasından sonra sonlanan, kutanöz ve mukokutanöz bulgularla karakterize bir durumdur. Bu çalışmada, ürtikeryal lezyonlarla seyreden ve otoimmün progesteron dermatiti tanısı konulan 42 ve 49 yaşındaki iki olgu sunulmaktadır. Her iki hastanın da menstrüel kanamadan bir ya da iki hafta önce başlayıp, kanamayla birlikte sonlanan ürtikeryal döküntü öyküsü vardı. Parenteral progesteron preparatı ile yapılan intradermal testler her iki hastada da pozitif olarak saptandı. Hastaların öyküsü, klinik bulguları ve progesteron ile yapılan intradermal testin pozitif olması sonucunda otoimmün progesteron dermatiti tanısı kondu. Bu çalışma, nadir görülen bir hastalık olması nedeniyle tanının atlanabileceğini ve iyi bir anamnezin tanıdaki önemini vurgulamak amacıyla sunulmuştur. Öz AbstractAutoimmune progesterone dermatitis is a rare hypersensitivity reaction that develops against endogenous progesterone. This condition is characterized by cutaneous and mucocutaneous findings that begins cyclically in the luteal phase of the menstrual cycle and ends after the onset of menstrual bleeding. In this study, we present two cases aged 42 and 49 years who were had urticarial lesions and diagnosed with autoimmune progesterone dermatitis. Both patients had a history of urticaria rash that started one or two weeks before the menstruation and ended with bleeding. Intradermal tests with parenteral progesterone preparation were found to be positive in both patients. As a result of patients' history, clinical findings and the positive intradermal test with progesterone, autoimmune progesterone dermatitis diagnosed. It has been aim to emphasize the importance of anamnesis in diagnosis of this rarely seen disease.

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Section: Discussionunclassified

Autoimmune Progesterone Dermatitis: Two Case Reports

Benar¹,

Cemil²,

Atay³

et al. 2018

tdd

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“…The reason for this sex difference is not clear, but may include the influence of sex hormones on the regulation of inflammation and an increased T h 2 immune response in women [10], which is further supported by the female predominance of chronic urticaria, a condition with a pathophysiology closely linked to acquired angioedema [11].…”

Section: Discussionmentioning

confidence: 99%

Orolingual angioedema after thrombolysis is not associated with insular cortex ischemia on pre-thrombolysis CT

Pinho

Alves

Oliveira³

et al. 2016

Journal of the Neurological Sciences

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Objective: Orolingual angioedema (OA) is a well known early complication of treatment with alteplase in ischemic stroke patients. Our aim was to study risk factors for OA in these patients, namely insular cortex ischemia. Methods: Retrospective case-cohort study using the prospective registry of all consecutive ischemic stroke patients submitted to intravenous thrombolysis with alteplase. Clinical data was retrieved from the registry and medical records. Two independent observers evaluated early signs of insular cortex ischemia on pre-thrombolysis computed tomography (CT) and of insular cortex infarct on early follow-up imaging. Univariate and multivariate analysis were performed to identify predictors of OA. Results: Of the 659 patients with acute ischemic stroke treated with alteplase, 32 developed OA (4.9%, 95%CI = 3.3-6.6). Frequency of early signs of insular cortex ischemia on pre-thrombolysis CT and of insular cortex infarct on follow-up imaging was similar in patients with and without OA (p = 0.241 and p = 0.145, respectively). The only independent predictors of OA occurrence were female sex (OR = 5.47, 95%CI = 1.98-15.10) and angiotensin-converting enzyme inhibitor (ACE-I) use (OR = 3.87, 95%CI = 1.71-8.75). Conclusions: Female sex and ACE-I use are independent risk factors for OA occurrence in ischemic stroke patients treated with alteplase. Early signs of insular cortex ischemia on pre-thrombolysis CT were not significantly associated with OA.

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“…10,11 Oleh karena itu, dengan pemilihan populasi di rentang usia ini diharapkan efek hormon DHEAS terhadap penyakit urtikaria akan lebih terlihat. Angioedema dijumpai sekitar 30% menyertai gejala klinis urtikaria pada kasus urtikaria kronis.…”

Section: Pembahasanunclassified

Hubungan Antara Kadar Hormon Dehydroepiandrosterone Sulfate (Dheas) Serum Dengan Aktivitas Penyakit Urtikaria Kronis Pada Perempuan

Brahmanti

Rofiq²,

Cholis³

2017

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AbstrakUrtikaria merupakan lesi kulit yang terdiri dari reaksi wheal dan flare. Sebanyak 15-20% penduduk pernah mengalami urtikaria dalam kehidupannya, dan 25% diantaranya mengalami urtikaria kronik. Kejadian urtikaria lebih banyak dijumpai pada perempuan. Adanya hubungan antara proses imunologis dan aktivitas neuroendokrin menjadi salah satu hipotesis yang mendasari patogenesis urtikaria. Ditemukannya peran DHEAS dalam fungsi imunomodulator dan antiinflamasi dapat menjadi dasar adanya peran dari terganggunya fungsi DHEAS akibat defisiensi dengan proses inflamasi pada urtikaria. Rancangan penelitian observasional potong lintang dilakukan untuk mengetahui adanya hubungan antara kadar hormon dehidroepiandrosteron sulfat (DHEAS) serum dengan aktivitas penyakit urtikaria kronis pada perempuan. Hasil uji Kruskall Wallis dengan post hoc Man Whittney menunjukkan adanya perbedaan yang bermakna antara aktivitas penyakit urtikaria dengan kadar DHEAS serum (p = 0,000). Analisis uji Spearman menunjukkan adanya korelasi negatif yang kuat antara aktivitas penyakit urtikaria dengan kadar DHEAS serum (r = -0,933; p = 0,000). Hal ini menunjukkan bahwa pada kadar yang lebih tinggi maka hormon DHEAS dapat bersifat protektif terhadap perburukan klinis urtikaria, dan sebaliknya pada kondisi urtikaria yang kronis terjadi penurunan kadar hormon DHEAS serum. Dapat disimpulkan bahwa pada wanita, ada hubungan antara kadar DHEAS serum dengan aktivitas penyakit urtikaria kronis. Hasil ini memperkuat kemungkinan terjadinya penurunan kadar DHEAS serum yang berperan dalam patogenesis urtikaria kronis.Kata kunci: aktivitas penyakit, dehidroepiandrosteron sulfat serum, urtikaria kronis SERUM LEVEL OF DEHYDROEPIANDROSTERONE SULFATE (DHEAS) AND THE RELATIONSHIP WITH CHRONIC URTICARIAL IN WOMEN AbstractUrticaria is a skin lesion consisting of wheal and flare reaction. As many as 15-20 % of the population had experienced urticaria in their lives, and 25% had chronic urticaria. Urticaria is more common in women. The relationship between immunological and neuroendocrine activity became one hypothesis underlying the pathogenesis of urticaria. The role of DHEAS in the immunomodulatory and antiinflammatory effects underline the role of DHEAS deficiency in the pathogenesis of urticaria. A cross-sectional observational study design was conducted to determine the relationship between serum levels of dehydroepiandrosterone sulfate (DHEAS) with disease activity in women with chronic urticaria. The statistical analysis using Kruskall Wallis test with posthoc Man Whittney showed significant difference between urticaria disease activity with serum DHEAS levels (p = 0.000). The correlation analysis using Spearman test showed a strong negative correlation between disease activity of urticaria with serum DHEAS level (r = -0,933; p = 0,000). This results suggest that higher level of DHEAS may be protective against clinical worsening of urticaria. In the other hand, in chronic urticaria condition, the level of DHEAS will be decline. It can be concluded, there is a r...

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Sex hormones and urticaria

Cited by 63 publications

References 61 publications

Autoimmune Progesterone Dermatitis: Two Case Reports

Autoimmune Progesterone Dermatitis: Two Case Reports

Orolingual angioedema after thrombolysis is not associated with insular cortex ischemia on pre-thrombolysis CT

Hubungan Antara Kadar Hormon Dehydroepiandrosterone Sulfate (Dheas) Serum Dengan Aktivitas Penyakit Urtikaria Kronis Pada Perempuan

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