Drug Reactions

Penicillamine-induced Elastosis Perforans Serpiginosa and Cutis Laxa in a Patient with Wilson's Disease

“…Most of the adverse effects of D-penicillamine are cutaneous and they occurring in 25∼50% of patients. These adverse effects can be classified into three groups 3 , including early onset morbilliform and urticarial hypersensitivity reactions and later onset bullous and lupus-like autoimmune reactions 9 . The third group of dermopathies is a spectrum of cutaneous elastotic and collagen disorders 3 such as PXE, EPS, cutis laxa and anectoderma 4,5 .…”

“…hypersensitivity reactions, autoimmune conditions and a spectrum of cutaneous elastotic and collagen disorders 3 .…”

Acute Generalized Exanthematous Pustulosis Caused by Diltiazem

“…The blood neutrophil count is usually elevated, and mild renal impairment occurs in approximately 30% of the cases; both of these abnormalities disappear with improvement of the eruption 1 . Other lesions that may be seen in patients with this dermatosis are erythema multiforme-like target lesions, vesicles, blisters or purpura 3 . Mucous membrane involvement, if it occurs, is generally mild and limited to one location.…”

“…The bacteriological and fungal examinations of the pustules are negative. In most patients the rash often develops within 24∼48 h of drug exposure on the face or in the flexures, and then it rapidly disseminates and lasts about 1∼2 weeks 1,3 . In addition, the EuroSCAR study observed 2 different patterns for the onset time after exposure to the offending agent.…”

Temazepam Overdose Associated with Bullous Eruptions

“…BE have been described with barbiturates, methadone, imipramine, and glutethimide overdoses. 1 Among the benzodiazepines, nitrazepam, 2 diazepam, 3 and oxazepam 4 have been associated with BE. We describe an 83-year-old woman presenting with coma and BE after an overdose with temazepam.…”