Autoimmune diseases in the intensive care unit. An update

Quintero, O. Lucía; Rojas-Villarraga, Adriana; Mantilla, Rubén D.; Anaya, Juan Manuel

doi:10.1016/j.autrev.2012.06.002

Cited by 84 publications

(97 citation statements)

References 138 publications

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“…This finding is similar to our group of patients, but infections were not serious as reported in other studies [17]. Furthermore, hospitalized lupus patients are more prone to develop nosocomial infections which are not related to steroid use [19].…”

Section: Discussionsupporting

confidence: 92%

“…In another study, risk factors for hospitalizations in lupus patients were recurrent hospitalizations in the past, younger age, and infection during hospitalization [17]. This finding is similar to our group of patients, but infections were not serious as reported in other studies [17].…”

Section: Discussionsupporting

confidence: 91%

“…SLE patients are more prone to infections for many reasons: inherent defective immune regulation, inherited complement deficiencies, and immune-suppression from medications [17,20]. Although SLE patients in our study were hospitalized for infections, none were considered severe infections or sepsis.…”

Section: Discussionmentioning

confidence: 92%

“…The annual rate of hospitalizations varies widely from up to 19% in one study, but others have claimed rates up to 80.8% [16]. Among autoimmune diseases including rheumatoid arthritis and systemic vasculitis, SLE patients had increased admission and mortality rates in the ICU [17].…”

Section: Introductionmentioning

confidence: 91%

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Good prognosis for hospitalized SLE patients with non-related disease

Zimlichman¹,

Rothschild²,

Shoenfeld³

et al. 2014

Autoimmunity Reviews

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 91%

See 2 more Smart Citations

Good prognosis for hospitalized SLE patients with non-related disease

Zimlichman¹,

Rothschild²,

Shoenfeld³

et al. 2014

Autoimmunity Reviews

View full text Add to dashboard Cite

“…Only a limited number of comparable publications on this subject are available (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13), and the different case-mix in the different studies makes adequate comparison difficult.…”

Section: Discussionmentioning

confidence: 99%

Outcome of patients with systemic diseases admitted to the medical intensive care unit of a tertiary referral hospital: a single-centre retrospective study

Heijnen

Wilmer

Blockmans

et al. 2015

Scandinavian Journal of Rheumatology

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Rotavirus-Associated Hospitalization in Children With Subsequent Autoimmune Disease

Kim

Ryeong

et al. 2023

JAMA Netw Open

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ImportanceRotavirus infection is a common cause of gastroenteritis in children that can trigger autoimmune processes, but the nature of this interaction remains poorly understood.ObjectiveTo estimate the association of rotavirus infection with the risk of subsequent autoimmune disease.Design, Setting, and ParticipantsThis population-matched cohort study used data from children and adolescents (aged younger than 18 years) in South Korea (national registers from January 1, 2002, to December 31, 2017). The cohort consisted of 86 157 patients in the exposure group who had experienced rotavirus-associated hospitalization and the same number of matched patients in the unexposed group. Data analyses were from May 1, 2020, through October 20, 2022.ExposuresHospitalization for rotavirus infection.Main Outcomes and MeasuresThe main outcome was childhood autoimmune diseases during the study defined by diagnoses according to the National Health Insurance Database. Hazard ratios (HRs) with 95% CIs for autoimmune diseases were estimated using a Cox model, with multiple confounding factors controlled.ResultsThis cohort study consisted of 1 914 461 individuals born in South Korea from 2002 to 2005 who were potentially eligible. After exclusions, there were 86 517 individuals in the exposed group and 86 517 in the unexposed group after 1:1 incidence density sampling. The study included 49 072 (57.0%) male patients. The median (IQR) age at diagnosis of rotavirus-associated hospitalization was 1.5 (0.9-2.7) years, and the HR for autoimmune disease in the exposed group was 1.24 (95% CI, 1.19-1.28) for a mean (SD) follow-up time of 12.1 (3.2) years. The use of more stringent definitions for exposure and outcomes in a multivariable stratified analysis also indicated that rotavirus-associated hospitalization was associated with an increased risk of subsequent autoimmune disease (HR, 1.22 [95% CI, 1.16-1.28]). Sensitivity analysis showed that individuals with rotavirus-associated hospitalization was related to multiple autoimmune syndromes (2 or more: HR, 1. 51 [95% CI, 1. 31-1. 73]; 3 or more: HR, 1. 79 [95% CI, 1.18-2.72]) and that the number of rotavirus-associated hospitalization were associated with higher risks for autoimmune disease in a dose-dependent manner (single hospitalization event: HR, 1.20 [95% CI, 1.16-1.24]; multiple events HR, 1.60 [95% CI, 1.49-1.72]).Conclusions and RelevanceOur results indicate that rotavirus-associated hospitalization is significantly associated with subsequent autoimmune disease during childhood. Clinicians should be aware of the heightened susceptibility to autoimmune disease in individuals with prior rotavirus-associated hospitalization.

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Autoimmune diseases in the intensive care unit. An update

Cited by 84 publications

References 138 publications

Good prognosis for hospitalized SLE patients with non-related disease

Good prognosis for hospitalized SLE patients with non-related disease

Outcome of patients with systemic diseases admitted to the medical intensive care unit of a tertiary referral hospital: a single-centre retrospective study

Rotavirus-Associated Hospitalization in Children With Subsequent Autoimmune Disease

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