Good prognosis for hospitalized SLE patients with non-related disease

Zimlichman, Eyal; Rothschild, Jacob E.; Shoenfeld, Yehuda; Zandman‐Goddard, Gisele

doi:10.1016/j.autrev.2014.08.033

Cited by 13 publications

(11 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent study on non-SLE-related admissions among SLE patients did not find SLEDAI-2K prognostic for the outcome of hospitalizations regarding duration, transfer to an ICU or readmission, suggesting that other specific SLE pathways are important for these outcomes. 28 Anaemia and kidney involvement are well-defined predictors of an adverse outcome, 1,33 but in the present study we could not confirm this association. This may relate to the limited number of patients under investigation.…”

Section: Discussioncontrasting

confidence: 76%

See 1 more Smart Citation

Hospitalizations among Danish SLE patients: a prospective study on incidence, causes of admission and risk factors in a population-based cohort

Busch

Kay

Voß

2017

Lupus

View full text Add to dashboard Cite

Objective To determine the incidence, duration and cause of hospitalization in a cohort of Danish patients with systemic lupus erythematosus (SLE). In addition, we investigated risk factors for admission and prolonged hospital stay. Methods A total of 155 SLE patients from a population-based cohort were included in the study during a period of 70 months, from January 2007 to October 2012. Data on frequency, cause and duration of hospitalizations were obtained by review of medical charts. Data on disease manifestations, organ damage and treatment were collected prospectively. Results A total of 101 of the 155 SLE patients (65%) had one or more hospitalization during the study period. The incidence rate of all hospitalizations was 0.50 per year. Leading causes of admission were complications to SLE or its treatment, but infections were also common. Mean duration of hospital stay was 6.4 ± 10.5 days, and SLE Disease Activity Index 2000 (SLEDAI-2K) on admission emerged as a risk factor for prolonged hospital stay. Conclusion Danish SLE patients experience frequent admissions to hospital. Complications to SLE or its treatment, as well as infections, are leading causes of admission. High SLEDAI-2K on admission is a risk factor for prolonged hospital stay.

show abstract

Section: Discussioncontrasting

confidence: 76%

“…Death occurred in 1% of the hospitalizations, which is lower than in previous studies in which a deadly outcome amounted to 2.8–9% of admissions. 8,9,11–14,17,24,28…”

Section: Discussionmentioning

confidence: 99%

Hospitalizations among Danish SLE patients: a prospective study on incidence, causes of admission and risk factors in a population-based cohort

Busch

Kay

Voß

2017

Lupus

View full text Add to dashboard Cite

show abstract

“…Also, new data show a marked decrease in the mortality of patients with rheumatic diseases when admitted with a critical illness 13 . A recent report indicated that the presence of an autoimmune disease is no longer a significant independent prognosticator for patients admitted to hospital for unrelated conditions 14 .…”

Section: Introductionmentioning

confidence: 99%

Prognosis of Patients with Rheumatic Diseases Admitted to Intensive Care

Beil

Sviri

Guardia

et al. 2017

Anaesth Intensive Care

View full text Add to dashboard Cite

Variable mortality rates have been reported for patients with rheumatic diseases admitted to an intensive care unit (ICU). Due to the absence of appropriate control groups in previous studies, it is not known whether the presence of a rheumatic disease constitutes a risk factor. Moreover, the accuracy of the Acute Physiology and Chronic Health Evaluation II (APACHE II) score for predicting outcome in this group of patients has been questioned. The primary goal of this study was to compare outcome of patients with rheumatic diseases admitted to a medical ICU to those of controls. The records of all patients admitted between 1 April 2003 and 30 June 2014 (n=4020) were screened for the presence of a rheumatic disease during admission (n=138). The diagnosis of a rheumatic disease was by standard criteria for these conditions. An age-and gender-matched control group of patients without a rheumatic disease was extracted from the patient population in the database during the same period (n=831). Mortality in ICU, in hospital and after 180 days did not differ significantly between patients with and without rheumatic diseases. There was no difference in the performance of the APACHE II score for predicting outcome in patients with rheumatic diseases and controls. This score, as well as a requirement for the use of inotropes or vasopressors, accurately predicted hospital mortality in the group of patients with rheumatic diseases. In conclusion, patients with a rheumatic condition admitted to intensive care do not do significantly worse than patients without such a disease.

show abstract

“…SLE is much more common in women than in men, with a female-to-male ratio of about 9 : 1 as commonly reported [ 1 – 3 ]. With the progress in medical care, there has been a striking rise in life quality for SLE in recent years with a mean estimated 5-year survival of 82%–90% [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

The Therapeutic Effects of the Chinese Herbal Medicine, Lang Chuang Fang Granule, on Lupus‐Prone MRL/lpr Mice

Huang

Zhang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that leads to severe multiorgan damage. Lang Chuang Fang (LCF) is a Chinese herbal medicine that is clinically prescribed for treating SLE. In this study, we examined the therapeutic effects of LCF granule on lupus-prone MRL/lpr mice. Female mice were randomly separated into six groups, and LCF treatment groups received LCF granule at the dosage of 0.97 g/kg/d, 1.95 g/kg/d, and 3.90 g/kg/d, respectively. Here, we found that, compared to the MRL/lpr mice, both the spleen coefficient and thymus coefficient were reduced in the LCF granule-treated mice. There was a marked downregulation in CRP and anti-dsDNA autoantibody and an evident upregulation of CH50 in LCF granule-treated mice. LCF granule treatment also obviously reduced the proteinuria, BUN, and SCr levels in MRL/lpr mice at the dosage of 0.97 g/kg/d, 1.95 g/kg/d, and 3.90 g/kg/d, indicating that LCF granule alleviated the renal injury of MRL/lpr mice. Furthermore, LCF granule decreased p65 NF-κB levels and increased Sirt1 and Nrf2 levels in the kidney tissues of MRL/lpr mice, which might elucidate the beneficial effects of LCF on lupus nephritis. In conclusion, this study demonstrates that LCF granule has therapeutic effects on lupus-prone MRL/lpr mice.

show abstract

Good prognosis for hospitalized SLE patients with non-related disease

Cited by 13 publications

References 24 publications

Hospitalizations among Danish SLE patients: a prospective study on incidence, causes of admission and risk factors in a population-based cohort

Hospitalizations among Danish SLE patients: a prospective study on incidence, causes of admission and risk factors in a population-based cohort

Prognosis of Patients with Rheumatic Diseases Admitted to Intensive Care

The Therapeutic Effects of the Chinese Herbal Medicine, Lang Chuang Fang Granule, on Lupus‐Prone MRL/lpr Mice

Contact Info

Product

Resources

About