Autoantibodies to inner ear and endothelial antigens in Cogan's syndrome

Lunardi, Claudio; Bason, Caterina; Leandri, Massimo; Navone, Riccardo; Lestani, Maurizio; Millo, Enrico; Benatti, Umberto; Cilli, Michele; Beri, Ruggero; Corrocher, Roberto; Puccetti, Antonio

doi:10.1016/s0140-6736(02)11028-2

Cited by 209 publications

(111 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3,5,6 SNHL can be the initial manifestation of a systemic autoimmune disease such as SS, systemic lupus erythematosus, granulomatosis with polyangiitis (Wegener's), 7 polyarteritis nodosa, rheumatoid arthritis, and Cogan's syndrome. 8,9 There is a significant association between thyroid autoimmunity and Ménière's disease, which can itself be very difficult to distinguish from AIED in the first months, 10 but our patient had no vestibular symptoms. The relationship between SS and AIED was studied by Tumiati et al, who suggested the performance of audiometric tests in patients with this syndrome.…”

Section: Discussionmentioning

confidence: 67%

Sensorineural hearing loss as the first manifestation of Sjögren's syndrome

Almeida¹,

Oliveira²,

Pego³

et al. 2017

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 67%

Sensorineural hearing loss as the first manifestation of Sjögren's syndrome

Almeida¹,

Oliveira²,

Pego³

et al. 2017

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

“…It is believed that Cogan's syndrome has a background of autoimmunity at its origin and is associated to other diseases that have the same characteristic (Wegener's disease, polyarteritis nodosa, rheumatoid arthritis) (8) . The atypical form of the disease is more related to the systemic commemorative ones, being more aggressive and of worse prognosis (3,6) .…”

Section: Discussionmentioning

confidence: 99%

Interstitial keratitis in patients with Cogan’s Syndrome

Martins¹,

Costa²,

Martins³

2017

Revista Brasileira De Oftalmologia

View full text Add to dashboard Cite

RESUMOA Síndrome de Cogan é caracterizada pela ceratite intersticial não luética associada à vertigem, tinnitus e disacusia neurossensorial. Relatamos um caso que ilustra um modelo da intervenção multidisciplinar no diagnóstico e tratamento da doença.Descritores: Manifestações oculares/diagnóstico; Síndrome; Vasculite; Surdez; Vertigem; Ceratite; Opacidade da córnea; Relatos de casos ABSTRACT Cogan's syndrome is characterized by interstitial keratitis non-syphilis associated with vertigo, tinnitus and sensorineural hearing loss. We report a case that illustrates a model of multidisciplinary intervention in the diagnosis and treatment of disease.

show abstract

“…Besides that, SSNHL may be the initial manifestation of Sjögren's syndrome, SLE, Wegener's granulomatosis, PAN and Cogan's syndrome 18,19 .…”

Section: Discussionmentioning

confidence: 99%

Sudden sensorineural hearing loss: a case report supporting the immunologic theory

Werneck

Gurgel

Mello

et al. 2003

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

-Sudden sensorineural hearing loss (SSNHL) is one of the autoimmune diseases of the inner ear (AIED), which is characterized by a hearing loss of above 30 decibels in at least three contiguous audiometric frequencies over a time course of 72 hours or shorter. Its cause can be found in only 10% to 15% of patients. Histopathologic findings have reported retrograde neuronal degeneration and atrophy of Corti's organ and of the vascular stria. This paper describes a case of a middle-aged female patient undergoing a treatment for hyperthyroidism who developed bilateral SSNHL. The patient was treated with methylprednilisone (1mg/kg/ day) for three days with considerable hearing improvement. This treatment was followed by lung and kidney tuberculosis. The immune mechanism of this entity and the possibility of interconnected participation of the antigen type, of an autoimmune disease and of bacterial infection are discussed.KEY WORDS: sudden sensorineural hearing loss, autoimmune disease, autoimmune thyroid disease, tuberculosis. Surdez neurosensorial súbita: relato de um caso clínico corroborando a teoria auto-imuneRESUMO -A surdez neurosensorial aguda (SNSA) é uma das doenças auto-imunes do ouvido interno caracterizada pela perda da audição acima de 30 decibéis, em pelo menos 3 freqüências audiométricas contíguas, no período máximo de 3 dias. Sua causa só é definida em 10 a 15% dos pacientes. Achados histopatológicos demonstram degeneração neuronal retrógrada e atrofia do órgão de Corti e da estria vascular. Relatamos o caso de uma paciente de média idade em tratamento de hipertireoidismo que apresentou SNSA bilateral. A paciente foi tratada com metil-prednisilona (1mg/kg/dia) durante três dias evoluindo para uma melhora considerável da audição. Este tratamento foi seguido de tuberculose pulmonar e renal. Discute-se o mecanismo imunológico desta entidade, e a possibilidade de participação cruzada do tipo antígeno, doença autoimune e infecção bacteriana. PALAVRAS-CHAVE: surdez neurosensorial aguda, doença auto-imune, doença auto-imune da tireóide, tuberculose.

show abstract

Autoantibodies to inner ear and endothelial antigens in Cogan's syndrome

Cited by 209 publications

References 28 publications

Sensorineural hearing loss as the first manifestation of Sjögren's syndrome

Sensorineural hearing loss as the first manifestation of Sjögren's syndrome

Interstitial keratitis in patients with Cogan’s Syndrome

Sudden sensorineural hearing loss: a case report supporting the immunologic theory

Contact Info

Product

Resources

About