Autoantibodies in Argentine Women with Recurrent Pregnancy Loss

Bustos, Daniel; Moret, Ana Yajaira; Tambutti, Mónica L.; Gogorza, S.; Testa, Roberto; Ascione, Amanda; Prigoshin, Norma

doi:10.1111/j.1600-0897.2005.00349.x

Cited by 37 publications

(33 citation statements)

References 37 publications

(37 reference statements)

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“…To our knowledge, this study reports -in relation to ANA -the highest overall number of RPL women collected so far, after the pioneering studies by Harger et al 14 and Kwak et al 20 Kwak et al did not find a significantly increased incidence of ANA in women with primary unexplained RPL compared to control women. 14 This finding might help explain also the differences in results between our data and those of Bustos et al, 19 in which the authors did not find any difference in the frequency of ANA positivity between RPL and control women using a median dilution of 1:40. Interestingly, in their study, Harger et al observed that no statistically significant differences in the frequency of ANA between RPL and control women were found when the serum titer considered positive was set at 1:40.…”

Section: Discussionsupporting

confidence: 47%

“…Similarly, the factors responsible for RPL of immunologic causes are largely unknown, with few exceptions represented by certain autoantibodies such as the antiphospholipid antibodies detectable by lupus anticoagulant, anticardiolipin or anti-b2 glycoprotein I assays. [16][17][18][19][20] This study was carried out to further investigate whether ANA can play a role in RPL and whether ANA detection can be of some clinical value in the diagnostic workup of women with RPL. [16][17][18][19][20] This study was carried out to further investigate whether ANA can play a role in RPL and whether ANA detection can be of some clinical value in the diagnostic workup of women with RPL.…”

Section: Introductionmentioning

confidence: 99%

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Antinuclear Autoantibodies in Women with Recurrent Pregnancy Loss

Ticconi

Rotondi

Veglia

et al. 2010

American J Rep Immunol

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Section: Discussionsupporting

confidence: 47%

Section: Introductionmentioning

confidence: 99%

Antinuclear Autoantibodies in Women with Recurrent Pregnancy Loss

Ticconi

Rotondi

Veglia

et al. 2010

American J Rep Immunol

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“…The age at diagnosis of CD, related to the exposure to gluten, could determine some changes in the endocrinology mechanisms that influence miscarriages [3]. Bustos et al reported a significantly higher prevalence of anticardiolipin, antigliadin, and anti-tissue transglutaminase antibodies in healthy women from Argentina with first trimester recurrent pregnancy loss, calling attention to the high prevalence of sub clinical CD among these individuals [30].…”

Section: Discussionmentioning

confidence: 99%

Mannan-Binding Lectin Levels Related to Spontaneous Abortion in Brazilian Patients with Celiac Disease

et al. 2008

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Low concentration of mannan-binding lectin (MBL) has been related to unexplained spontaneous abortion (SA), which has also been observed in an increased frequency in patients with celiac disease (CD). In this study, plasma levels of MBL were determined in patients with CD and irritable bowel syndrome (IBS) in order to investigate whether there is an association of MBL levels and the occurrence of SA in these patients. MBL concentration was determined in 46 patients with CD (28 without and 18 with report of SA) and 38 patients with IBS (25 without and 13 with report of SA). A higher frequency of SA was observed in women with CD when compared to IBS patients (23.2 vs. 13.9%; P = 0.046). No significant difference was observed in MBL concentrations between patients with CD, IBS, and healthy controls, nor between patients with or without occurrence of SA. These results suggest that the serum levels of MBL and the occurrence of SA in women with CD and IBS are not causally related.

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“…Anti-gliadin IgG is elevated in women with recurrent fetal loss compared to fertile women (16). Gliadin receptors are abundant in the extravillous trophoblasts, which are essential for placental attachment to the mother and also aid in fetal blood supply (12).…”

Section: Discussionmentioning

confidence: 99%

Successful Pregnancy on a Gluten-Free Diet in a Woman with Seven Miscarriages and Nonceliac Gluten Sensitivity

Bennett

Gupta

2018

AACE Clinical Case Reports

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Objective: To describe a case in which a glutenfree diet led to a successful full-term delivery in a woman with recurrent miscarriages and nonceliac gluten sensitivity (NCGS).Methods: Reduced incidences of spontaneous abortions have been reported in patients with celiac disease who adhere to a gluten-free diet, but little is known about improvement in reproductive issues in women with NCGS. We present a case of a woman with multiple miscarriages who improved on a gluten-free diet.Results: A 33-year-old woman presented with history of hypothyroidism and recurrent first-trimester fetal loss. On exam, body mass index was 24.9 kg/m 2 , and she did not appear cushingoid. She was on levothyroxine, and thyroid function tests were within normal limits. Thyroid peroxidase antibody and anti-phospholipid antibody were negative. Although she denied gastrointestinal symptoms, undiagnosed celiac disease was considered, as she had family members with celiac disease. Anti-gliadin immunoglobulin (Ig)G antibody was elevated, while tissue transglutaminase IgA and anti-endomysial IgA were negative. Esophagogastroduodenoscopy and biopsy showed normal mucosa. These findings were consistent with a diagnosis of NCGS. A trial with a gluten-free diet was initiated. She became pregnant again and was able to carry the baby to full-term with delivery.Conclusion: While the exact effect of NCGS is yet to be determined, immunologic changes in placental function may account for recurrent fetal loss since gliadin is abundant in the extravillous trophoblast that attaches the placenta to the mother. (AACE Clinical Case Rep. 2018;4:e443-e446) Abbreviations: ACTH = adrenocorticotropic hormone; Ig = immunoglobulin; NCGS = nonceliac gluten sensitivity

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Autoantibodies in Argentine Women with Recurrent Pregnancy Loss

Cited by 37 publications

References 37 publications

Antinuclear Autoantibodies in Women with Recurrent Pregnancy Loss

Antinuclear Autoantibodies in Women with Recurrent Pregnancy Loss

Mannan-Binding Lectin Levels Related to Spontaneous Abortion in Brazilian Patients with Celiac Disease

Successful Pregnancy on a Gluten-Free Diet in a Woman with Seven Miscarriages and Nonceliac Gluten Sensitivity

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