Mannan-Binding Lectin Levels Related to Spontaneous Abortion in Brazilian Patients with Celiac Disease

Abstract

Low concentration of mannan-binding lectin (MBL) has been related to unexplained spontaneous abortion (SA), which has also been observed in an increased frequency in patients with celiac disease (CD). In this study, plasma levels of MBL were determined in patients with CD and irritable bowel syndrome (IBS) in order to investigate whether there is an association of MBL levels and the occurrence of SA in these patients. MBL concentration was determined in 46 patients with CD (28 without and 18 with report of SA) and 38 patients with IBS (25 without and 13 with report of SA). A higher frequency of SA was observed in women with CD when compared to IBS patients (23.2 vs. 13.9%; P = 0.046). No significant difference was observed in MBL concentrations between patients with CD, IBS, and healthy controls, nor between patients with or without occurrence of SA. These results suggest that the serum levels of MBL and the occurrence of SA in women with CD and IBS are not causally related.

Results fromAd Hocand Routinely Collected Data among Celiac Women with Infertility or Pregnancy Related Disorders: Italy, 2001–2011

“…CD has been associated with recurrent spontaneous abortion [10–20], intrauterine growth restriction, preterm delivery and low-birth weight [11–14, 16–27], infertility, delayed menarche, early menopause, and stillbirth [11, 28–32]. The risk of multiple abortions is 8 to 9 times higher in women with untreated CD than among treated patients [15].…”

Celiac Disease Clinical, Pathophysiological, Epidemiological and Therapeutical Repertoire is Expanding

“…The lectin hypothesis of CD started in 1972 by Ament, Douglas, Weiser, et al [2,3,4]. It is quite controversial between the pros [5,6,7,8], and cons [9,10]. The annual number of publications is decreasing in the last decade.…”