Antinuclear Autoantibodies in Women with Recurrent Pregnancy Loss

Ticconi, Carlo; Rotondi, Federica; Veglia, Manuela; Pietropolli, Adalgisa; Bernardini, Sergio; Ria, Francesco; Caruso, Alessandro; Simone, Nicoletta Di

doi:10.1111/j.1600-0897.2010.00863.x

Cited by 67 publications

(55 citation statements)

References 41 publications

(80 reference statements)

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“…Also anyone who tests positive for antinuclear antibody, or anti-thyroid peroxidase, or other autoantibodies even without a confirmed autoimmune disease [13,[20][21][22]. Studies have shown increased rates of these antibodies in RPL patients [2,[23][24][25][26].…”

Section: Diagnostic Criteria Of Recurrent Pregnancy Lossmentioning

confidence: 99%

Immunogenetic contributions to recurrent pregnancy loss

Grimstad

Krieg

2016

J Assist Reprod Genet

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While sporadic pregnancy loss is common, occurring in 15 % of pregnancies, recurrent pregnancy loss (RPL) impacts approximately 5 % of couples. Though multiple causes are known (including structural, hormonal, infectious, autoimmune, and thrombophilic causes), after evaluation, roughly half of all cases remain unexplained. The idiopathic RPL cases pose a challenging therapeutic dilemma in addition to incurring much physical and emotional morbidity. Immunogenetic causes have been postulated to contribute to these cases of RPL. Natural Killer cell, T cell expression pattern changes in the endometrium have both been shown in patients with RPL. Human leukocyte antigen (HLA) and cytokine allelic variations have also been studied as etiologies for RPL. Some of the results have been promising, however the studies are small and have not yet put forth outcomes that would change our current diagnosis and management of RPL. Larger database studies are needed with stricter control criteria before reasonable conclusions can be drawn.

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Section: Diagnostic Criteria Of Recurrent Pregnancy Lossmentioning

confidence: 99%

Immunogenetic contributions to recurrent pregnancy loss

Grimstad

Krieg

2016

J Assist Reprod Genet

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“…A recent study suggested that the higher chemokine/cytokine activity during pregnancy in SLE patients increases pregnancyrelated complications and disease fl ares, despite a similar pattern of chemokine/cytokine fl uctuations in healthy pregnant women (5). Pregnancy and SLE aff ect the immune system, increasing the risk of pregnancy-related complications such as abortions, stillbirths, prematurity, preeclampsia, and intrauterine growth retardation (6,7). Antinuclear antibodies at low titers are more common in women with recurrent pregnancy loss (50%) than in controls (16%) (6).…”

mentioning

confidence: 99%

“…Pregnancy and SLE aff ect the immune system, increasing the risk of pregnancy-related complications such as abortions, stillbirths, prematurity, preeclampsia, and intrauterine growth retardation (6,7). Antinuclear antibodies at low titers are more common in women with recurrent pregnancy loss (50%) than in controls (16%) (6). In a recent meta-analysis of pregnancy outcomes in patients with SLE and lupus nephritis, the maternal complications were determined as lupus fl are (25.6%), hypertension (16.3%), nephritis (16.1%), preeclampsia (7.6%), and eclampsia (0.8%).…”

mentioning

confidence: 99%

Pregnancy-Associated Systemic Lupus Erythematosus

Ergin

2014

Baylor University Medical Center Proceedings

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“…Various immunological disorders have been observed in women with URSA, such as antiphospholipid antibody antibodies, antinuclear antibody (ANA), antithyroglobulin antibody and increased natural killer (NK) cell (Ticconi et al, 2010;Motak-Pochrzest et al, 2013;Youan et al, 2015). Animal studies have found evidence of a link between successful pregnancy and the predominant levels of anti-inflammatory cytokines relative to inflammatory cytokines.…”

Section: Introductionmentioning

confidence: 99%

Effect of Vitamin D Supplementation on Unexplained Recurrent Spontaneous Abortion: A Double-Blind Randomized Controlled Trial

Samimi¹,

Foroozanfard²,

Amini³

et al. 2016

GJHS

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Background: Recurrent spontaneous abortion is a serious problem in pregnancy, which affects between 2 and 5% of women of reproductive age. This study was designed to examine the effect of vitamin D supplementation on the occurrence of unexplained recurrent spontaneous abortion (URSA). Methods:A double-blind randomized and controlled clinical trial was performed on 80 patients with URSA. They were treated with vaginal progesterone (400 IU/day) after confirmation of pregnancy and received vitamin D and placebo in two intervention (n=40) and control groups (n=40), respectively. The incidence of abortion and the serum levels of IL-23 were examined within 20 weeks of gestation. Results:The levels of vitamin D3 prior to the start of the study were equal to 11.65±3.76 ng/ml and 11.53±2.39 ng/ml (p=0.86) in the intervention and control groups, respectively, which were decreased to 13.21±3.47 ng/ml and 11.08±2.76 ng/ml (p=0.004) at the end of the study, when the mean serum levels of IL-23 were equal to 18.4±3.78 pg/ml and 23.16±4.74 pg/ml in the two groups (p <0.004). The frequency of abortion in the control and intervention groups was equal to 5 (12.8%) and 13 (34.2%), respectively (p=0.03, OR=3.53, 95% CI= 1.12-11.2). Conclusions:Vitamin D3 leads to decreased serum levels of IL-23 and incidence of abortion among women with URSA.

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Antinuclear Autoantibodies in Women with Recurrent Pregnancy Loss

Abstract: ANA could be of some value in identifying women with RPL with potential, although still not fully defined, immune abnormalities.

Cited by 67 publications

References 41 publications

Immunogenetic contributions to recurrent pregnancy loss

Immunogenetic contributions to recurrent pregnancy loss

Pregnancy-Associated Systemic Lupus Erythematosus

Effect of Vitamin D Supplementation on Unexplained Recurrent Spontaneous Abortion: A Double-Blind Randomized Controlled Trial

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