Augmentation of anti-influenza virus hemagglutinin antibody production by Peyer's patch cells with Bifidobacterium breve YIT4064

Abstract

Bifidobacterium breve YIT4064 was tested an an adjuvant for oral influenza vaccine by the murine Peyer's patch cell culture method. The organism augmented production of anti-influenza virus hemagglutinin immunoglobulin A antibody by Peyer's patch cells in response to addition of hemagglutinin. These antibodies may be disseminated to the respiratory mucosal tissue and prevent influenza virus infection.

Protection against Influenza Virus Infection of Mice Fed Bifidobacterium breve YIT4064

“…The number of surface-IgG-positive cells was very low in PP (6), and anti-HA IgG was not produced upon the addition of HA antigen to a PP cell culture (31). Therefore, it was not thought that after PR8 was taken up by M cells in PP, anti-PR8 IgG was produced in PP.…”

“…We have found one strain of Bifidobacterium (Bifidobacterium breve YIT4064) that can induce large quantities of IgA among the many strains of bifidobacteria isolated from human feces by the murine Peyer's patch (PP) cell culture method (30). The organism enhances the production of anti-influenza virus HA (31), antirotavirus, and antipoliovirus antibodies (unpublished data) by PP cells in response to the addition of HA, rotavirus, and poliovirus, respectively. When the organism was administered orally to mice with cholera toxin (CT), the amount of anti-CT IgA in feces and the levels of anti-CT IgA production and proliferation in PP cells were significantly greater than those after the administration of CT alone or of CT and B. breve YIT4079, which did not induce IgA in the in vitro PP cell culture (30).…”

Influence of several non-nutrient additives on nonspecific immunity and growth of juvenile turbot,Scophthalmus maximusL.

“…Although the influence of some non‐nutrient feed additives on disease resistance has been documented in mammals and humans (Huhtanen 1979; Yasui et al. 1994; Savage et al.…”

Features of the Immune Response and Efficacy Immunotherapy for Rotavirus Infection in Children

“…Пероральный способ введения пробиотиков и колонизация бифидобактериями и лактобациллами преимущественно толстого кишечника не ограничивает их влияние на иммунитет лишь иммунокомпетентными клетками ЖКТ [27]. Установлено, что бифидобактерии и различные виды лактобацилл, включая L. plantarum, взаимодействуя с М-клетками пейеровых бляшек и эпителиальными клетками в кишечнике, способны индуцировать специфический иммунный ответ на различные антигены; при этом повышалось содержание В-лимфоцитов и титров продуцируемых ими антител класса IgA в слизистой оболочке дыхательных путей [32,33].…”