Features of the Immune Response and Efficacy Immunotherapy for Rotavirus Infection in Children

Горбунов, С. Г.; Мазанкова, Л. Н.; Майкова, И. Д.; Демина, О. И.; Коваль, Е. П.

doi:10.22627/2072-8107-2018-17-3-38-46

Det. infekc.

2018

DOI: 10.22627/2072-8107-2018-17-3-38-46

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Features of the Immune Response and Efficacy Immunotherapy for Rotavirus Infection in Children

С. Г. Горбунов

Л. Н. Мазанкова

И. Д. Майкова

et al.

Abstract: В статье отражены изменения как клеточного, так и гуморального звеньев иммунитета при ротавирусной инфекции, а также показана корреляция между степенью выраженности иммунологических нарушений и особенностями клинического течения заболевания в детском возрасте. Наиболее значительные изменения цитокинового статуса связаны с повышением интерлейкина-1, который является маркером интоксикации. Кроме того, при ротавирусной инфекции у детей снижается уровень индуцированных интерферонов  и , что служит обоснованием … Show more

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Cited by 3 publications

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“…According to the World Health Organization, rotavirus infection (RVI) remains one of the leading causes of gastrointestinal diseases in children of younger age [3]. There is a large number of publications in the available literature devoted to the study of various aspects of rotavirus infection in children [5,6]. During last decade a numerous researches devoted to influence of herpesvirus infection on clinical and laboratory parameters of infectious diseases in children have been presented [1,2,9].…”

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Clinical and Laboratory Predictors of Latent Herpesvirus Infection in Children With Rotavirus Gastroenteritis

Sliepchenko

2021

RS Global - World Science

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To achieve the aim there has been examined 104 children aged 1–3 years with moderate and severe forms of intestinal infection of rotavirus etiology, for which they received appropriate treatment in Kharkiv Regional Children's Infectious Diseases Clinical Hospital. Patients were divided into 2 groups: 1 group — 33 children with no concomitant herpesvirus, and 2 groups — 71 patients with rotavirus gastroenteritis and latent herpesvirus infection, caused by cytomegalovirus, Epstein-Barr virus or human herpes virus 6. Children in examined groups were comparable by gender, age, severity of main disease and other parameters.Prognosis of latent herpesvirus infection was made by means of multiple binomial regression. Independent predictors of concomitant herpesvirus infection included maximal daily number of vomiting, maximal increase of body temperature, time of onset of catarrhal symptoms since beginning of disease, level of ketone bodies in urine, amount of leukocytes, rod-shaped neutrophils and eosinophils in common blood count during acute phase of disease. As a reference group, we used respective clinical and paraclinical indices of patients with rotavirus infection only. Accuracy of model is 81.73 %.

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Clinical and Laboratory Predictors of Latent Herpesvirus Infection in Children With Rotavirus Gastroenteritis

Sliepchenko

2021

RS Global - World Science

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“…Introduction. Rotavirus infection (RVI) is the most common cause of diarrhea in childhood [1,2]. According to WHO experts, almost every child during the first three to five years of life suffers from specified infection, despite on of nationality, race and socio-economic status of the family [8,14].…”

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confidence: 99%

Clinical and Immunological Features of Rotavirus Gastroenteritis in Children Infected With Herpes Viruses

Kuznecov

Sliepchenko

2019

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The article presents the results of a comparative analysis of clinical and immunological parameters in children with rotavirus gastroenteritis without background infection and those infected by herpes viruses. It was established that in children with rotavirus infection (RVI) on the background of infection by herpes viruses occurs with less pronounced symptoms of intoxication and a less frequency of vomiting at the onset of the disease, in combination with longer duration (more long period) of fever and diarrheal syndrome. Such features are probably associated with the formation of a hypergical regime of the functioning of the immune response in the group of patients with background infection by herpes viruses, in contrast to patients with mono- RVI, in whom the immune system functions in a normal compensation mode.

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Experience with the use of the drug cycloferon in the treatment of rotaviral infection in children

Bochkareva

Полежаева

et al. 2022

Medicinskij sovet

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Introduction. Rotavirus infection is the leading cause of acute gastroenteritis in young children. Due to the lack of etiotropic treatment of viral gastroenteritis, the interest of scientists and practitioners in the use of antiviral drugs is increasing. Studies of domestic authors have proven that the low molecular weight interferon inductor – meglumine acridonacetate has antiviral, immunoregulatory and anti-inflammatory activity.Aim. Evaluation of the efficacy and safety of the antiviral drug meglumine acridonacenate in the treatment of acute gastroenteritis of rotavirus etiology in children aged 4–7 years in a hospital setting.Materials and methods. A prospective analysis of cases of treatment with meglumine acridonacetate for moderately severe rotavirus gastroenteritis in preschool children (n = 29, group I) was carried out. The comparison group consisted of patients receiving standard therapy (n = 31, group II). The presence of rotavirus infection was confirmed by the detection of the pathogen antigen in the feces. Meglumine acridonacetate was prescribed according to the scheme, parenterally, every other day.Results and discussion. The effectiveness of therapy with an antiviral drug on the 3rd day of treatment of moderately severe rotavirus gastroenteritis was 79.3% (p < 0.05). The elimination of the main clinical symptoms of the disease was noted on days 2–3: a decrease in the symptoms of intoxication, fever, a significant decrease in the duration of vomiting and diarrhea (p < 0.05), a reduction in the pathogen elimination period by 2.67 days (p < 0.01), meglumine acridonacetate was well tolerated, no side effects of the drug were detected.Conclusions. Meglumine acridonacetate can be recommended for the complex treatment of moderate rotavirus infection from the first days of the disease.

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Features of the Immune Response and Efficacy Immunotherapy for Rotavirus Infection in Children

Cited by 3 publications

References 22 publications

Clinical and Laboratory Predictors of Latent Herpesvirus Infection in Children With Rotavirus Gastroenteritis

Clinical and Laboratory Predictors of Latent Herpesvirus Infection in Children With Rotavirus Gastroenteritis

Clinical and Immunological Features of Rotavirus Gastroenteritis in Children Infected With Herpes Viruses

Experience with the use of the drug cycloferon in the treatment of rotaviral infection in children

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