Auditory Late Potentials in Normal-Hearing Adult Subjects With Down’s Syndrome

Arisi, E.; Forti, Stella; Amadeo, Chiara; Fagnani, E.; Filipponi, E.; Iacona, Elisabetta; Ambrosetti, Umberto; Cesarani, Antonio

doi:10.1097/mao.0b013e3182659d02

Cited by 7 publications

(3 citation statements)

References 20 publications

(16 reference statements)

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“…Such findings corroborate those of previous studies in which no statistically significant differences were found between the ears for latency values of the BAEP and P300 in audiologically normal individuals and in individuals with Down syndrome (21,22) . These results reinforce the fact that, for individuals with DS, the reference values and analysis criteria for the BAEP and P300 with non-complex stimuli (clicks and tone burst) can be used equally for both ears, as it already occurs in clinical practice in individuals with typical development.…”

Section: Discussionsupporting

confidence: 83%

Caracterização eletrofisiológica da audição em indivíduos com Síndrome de Down

Kazan

Samelli

Neves-Lobo

et al. 2016

CoDAS

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RESUMO Introdução Poucos estudos realizaram, concomitantemente, o potencial evocado auditivo de tronco encefálico (PEATE) e o P300 na Síndrome de Down (SD), em indivíduos audiologicamente normais, para a avaliação da via auditiva central, principalmente pela dificuldade de realizar estes procedimentos nesta população. Estudos anteriores sugeriram que indivíduos com SD podem apresentar padrões de respostas diferentes das encontradas em indivíduos com desenvolvimento típico, sendo que a identificação destes seria fundamental para o estabelecimento de um diagnóstico audiológico preciso. Objetivo Caracterizar o PEATE e o P300 em indivíduos com SD audiologicamente normais. Método Foram analisados o PEATE e o P300 de 17 indivíduos com SD e 21 com desenvolvimento típico de sete a 15 anos. A análise foi quantitativa e qualitativa, utilizando medidas descritivas e os testes de hipótese. Resultados Os valores de latência foram menores no PEATE para o grupo SD, com diferença estatisticamente significante para a onda V, interpicos III-V e I-V; não foram encontradas diferenças significantes nos valores de latência do P300. Observou-se maior número de indivíduos com valores precoces para as latências do PEATE e com latências atrasadas para o P300 no grupo SD; ambas as comparações mostraram diferenças significantes. Conclusão Crianças e adolescentes com SD podem apresentar respostas precoces para os componentes do PEATE, sugerindo que a via auditiva destes necessita de menor tempo para a transmissão neural do estímulo acústico até o tronco encefálico. Quanto ao P300, indivíduos com SD podem apresentar latências aumentadas, sugerindo comprometimento na via auditiva central quanto ao processamento cortical da informação auditiva.

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Section: Discussionsupporting

confidence: 83%

Caracterização eletrofisiológica da audição em indivíduos com Síndrome de Down

Kazan

Samelli

Neves-Lobo

et al. 2016

CoDAS

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“…1979 ), reduced electrical permeability of neural membranes and dendritic spine numbers ( Lott and Dierssen 2010 ), as well as changes in synaptic morphology ( Scott et al. 1983 ; Lott and Dierssen 2010 ) could underlie the reduced cerebral reactivity in people with DS ( Arisi et al. 2012 ).…”

Section: Discussionmentioning

confidence: 99%

The mismatch negativity as an index of cognitive abilities in adults with Down syndrome

et al. 2023

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Down syndrome (DS) is associated with an ultra-high risk of developing Alzheimer’s disease (AD). Understanding variability in pre-AD cognitive abilities may help understand cognitive decline in this population. The mismatch negativity (MMN) is an event-related potential component reflecting the detection of deviant stimuli that is thought to represent underlying memory processes, with reduced MMN amplitudes being associated with cognitive decline. To further understand the MMN in adults with DS without AD, we explored the relationships between MMN, age, and cognitive abilities (memory, language, and attention) in 27 individuals (aged 17–51) using a passive auditory oddball task. Statistically significant MMN was present only in 18 individuals up to 41 years of age and the latency were longer than canonical parameters reported in the literature. Reduced MMN amplitude was associated with lower memory scores, while longer MMN latencies were associated with poorer memory, verbal abilities, and attention. Therefore, the MMN may represent a valuable index of cognitive abilities in DS. In combination with previous findings, we hypothesize that while MMN response and amplitude may be associated with AD-related memory loss, MMN latency may be associated with speech signal processing. Future studies may explore the potential impact of AD on MMN in people with DS.

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“…Researchers have highlighted differences between the DS and TD populations in the form of longer movement onset and reaction times (Arisi, et al, 2012;Davis, Sparrow, & Ward, 1991;Henderson, Illingworth, & Allen, 1991;Masumoto, Abe, & Inui, 2012), longer movement times, and greater movement errors for DS compared to TD (Elliott, Welsh, Lyons, Hansen, & Wu, 2006;Hodges, Cunningham, Lyons, Kerr, & Elliot, 1995). These perceptual-motor impairments have been attributed to both central processes (i.e., Frith & Frith, 1974) and peripheral anatomical characteristics (Henderson et al, 1991;Morris, Vaughan, & Vaccaro, 1982).…”

Section: Introductionmentioning

confidence: 99%

Sequential aiming movements and the one-target advantage in individuals with Down syndrome

Lawrence

Reilly

Mottram

et al. 2013

Research in Developmental Disabilities

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Research has revealed that individuals with Down syndrome (DS) have elevated reaction times, longer movement times, and greater movement errors during single-target single-limb actions compared to their typically developing (TD) peers. These perceptualmotor impairments have been attributed to both central processes and the physical phenotype associated with DS. The purpose of the present study was to directly investigate these possible central and peripheral deficits by examining how individuals with DS plan and execute more complex movements. Three groups (DS, TD, and individuals with an undifferentiated intellectual disability; UID) of 8 participants completed a single target movement, a two-target movement performed by a single arm, and a two-target movement where the first movement was performed with one arm and the second movement performed with the other arm. For all groups and all conditions, movement times revealed a one-target advantage (OTA). Specifically, times to the first target were longer in the two-target responses compared to the single-target response. In general, the OTA finding reveals that persons with DS utilise planning strategies similar to their TD peers when performing sequential actions involving two targets and two arms. Furthermore, because the OTA was observed in both the single-and two-arm two-target responses the interference in movement one associated with having to make a subsequent movement is not due to peripheral processes associated with single limb constraints. Rather, individuals with DS treat movements within a sequence as functionally dependent. Thus, the central processes associated with the timing of the implementation of the second element of the movement appear to be responsible for the interference that leads to the OTA. MOVEMENT INTEGRATION IN PERSONS WITH DOWN SYNDROME3

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Auditory Late Potentials in Normal-Hearing Adult Subjects With Down’s Syndrome

Abstract: Our study demonstrated that ALP longer latencies are present in adult DS participants even when they have a normal hearing threshold, regardless of handedness and head size.

Cited by 7 publications

References 20 publications

Caracterização eletrofisiológica da audição em indivíduos com Síndrome de Down

Caracterização eletrofisiológica da audição em indivíduos com Síndrome de Down

The mismatch negativity as an index of cognitive abilities in adults with Down syndrome

Sequential aiming movements and the one-target advantage in individuals with Down syndrome

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