Atypical ductal hyperplasia of the breast: The controversial management of a borderline lesion: Experience of 47 cases diagnosed at vacuum-assisted biopsy

Bedei, Lucia; Falcini, Fabio; Sanna, Paola; Giunchi, Donata Casadei; Innocenti, M.P.; Vignutelli, P.; Saragoni, Luca; Folli, Secondo; Amadori, Dino

doi:10.1016/j.breast.2005.05.008

Cited by 31 publications

(34 citation statements)

References 32 publications

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“…Until now, VABB was established as a safe and effective method for the preoperative diagnosis of breast cancer. However, the main disadvantage of this method is underestimation; as mentioned above, the underestimation rate in different studies ranges between 0% and 35% in ADH and reaches 50% in DCIS [14][15][16][17]. It is evident that there is a crucial need for a novel, standardized protocol minimizing or even eliminating underestimation.…”

Section: Discussionmentioning

confidence: 98%

“…This has led to the taking of 24-36 cores in the common clinical practice. Noticeably, the exact number of offsets used is not definite in the majority of studies, and the mean number of cores excised does not exceed 23 cores [11][12][13][14][15][16][23][24][25][26][27].…”

Section: Discussionmentioning

confidence: 99%

“…Up to 50% of the lesions diagnosed as DCIS by VABB show foci of invasion on histopathological examination after surgical excision of these lesions [14,15]. As far as ADH is concerned, the underestimation rate ranges between 0% and 35% [16,17]. Thus, an interesting question emerges: does the removal of larger breast tissue volume result in decreasing underestimation?…”

Section: Introductionmentioning

confidence: 97%

“…However, even though the use of VABB is very appealing, its underestimation rate which ranges between 0% and 30% in various studies, is its weak point and may render the management of both atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS) difficult [14][15][16][17]. Up to 50% of the lesions diagnosed as DCIS by VABB show foci of invasion on histopathological examination after surgical excision of these lesions [14,15].…”

Section: Introductionmentioning

confidence: 99%

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Minimizing underestimation rate of microcalcifications excised via vacuum-assisted breast biopsy: a blind study

Zografos¹,

Zagouri

Sergentanis

et al. 2007

Breast Cancer Res Treat

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Minimizing underestimation rate of microcalcifications excised via vacuum-assisted breast biopsy: a blind study

Zografos¹,

Zagouri

Sergentanis

et al. 2007

Breast Cancer Res Treat

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“…Despite the significant rate of false-negative results of percutaneous biopsy in published series, the need for surgical excision of all atypical epithelial hyperplasia is controversial [11][12][13].…”

Section: Discussionmentioning

confidence: 99%

Histology after lumpectomy in women with epithelial atypia on stereotactic vacuum-assisted breast biopsy

Graesslin

Antoine

Chopier

et al. 2010

European Journal of Surgical Oncology (EJSO)

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. M A N U S C R I P T A C C E P T E D

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Pharmacokinetic mapping for lesion classification in dynamic breast MRI

Schabel

Morrell

et al. 2010

Magnetic Resonance Imaging

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PURPOSE To prospectively investigate whether a rapid dynamic MRI protocol, in conjunction with pharmacokinetic modeling, could provide diagnostically useful information for discriminating biopsy-proven benign lesions from malignancies. MATERIALS AND METHODS Patients referred to breast biopsy based on suspicious screening findings were eligible. After anatomic imaging, patients were scanned using a dynamic protocol with complete bilateral breast coverage. Maps of pharmacokinetic parameters representing transfer constant (Ktrans), efflux rate constant (kep), blood plasma volume fraction (vp), and extracellular extravascular volume fraction (ve) were averaged over lesions and used, with biopsy results, to generate receiver operating characteristic curves for linear classifiers using one, two, or three parameters. RESULTS Biopsy and imaging results were obtained from 93 lesions in 74 of 78 study patients. Classification based on Ktrans and kep gave the greatest accuracy, with an area under the ROC curve of 0.915, sensitivity of 91%, and specificity of 85%, compared to values of 88% and 68%, respectively, obtained in a recent study of clinical breast MRI in a similar patient population. CONCLUSION Pharmacokinetic classification of breast lesions is practical on modern MRI hardware and provides significant accuracy for identification of malignancies. Sensitivity of a two-parameter linear classifier is comparable to that reported in a recent multi-center study of clinical breast MRI, while specificity is significantly higher.

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Atypical ductal hyperplasia of the breast: The controversial management of a borderline lesion: Experience of 47 cases diagnosed at vacuum-assisted biopsy

Cited by 31 publications

References 32 publications

Minimizing underestimation rate of microcalcifications excised via vacuum-assisted breast biopsy: a blind study

Minimizing underestimation rate of microcalcifications excised via vacuum-assisted breast biopsy: a blind study

Histology after lumpectomy in women with epithelial atypia on stereotactic vacuum-assisted breast biopsy

Pharmacokinetic mapping for lesion classification in dynamic breast MRI

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