Atypical carcinoid of the larynx and expressions of proteins associated with molecular targeted therapy

Kanazawa, Takeharu; Takeoda, Katsuji; Kodama, Kozue; Usubuchi, Hajime; Iino, Yukiko

doi:10.1016/j.anl.2010.05.008

Cited by 8 publications

(10 citation statements)

References 14 publications

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“…Since 2005, an additional 42 cases (including our present case) have been described (Table 2 ). 9,32,41,46–55 Of these recent cases, 23 were males and 17 females; the genders of 2 were not specified. The male-to-female ratio was thus approximately 1.4:1, lower than those reported by Woodruff and Senie (1991) 44 and Ferlito et al (2005, 2006).…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous and Subcutaneous Metastases From Atypical Laryngeal Carcinoids

Wang¹,

Jia²,

Zhou³

et al. 2016

Medicine

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The incidence of cutaneous and subcutaneous metastases from atypical laryngeal carcinoids is approximately 20%. However, the pathogenesis and natural history of, and prognostic factors for, the condition remain poorly understood. We reported a 54-year-old female presented with cutaneous and subcutaneous metastases from atypical laryngeal carcinoid. Laryngoscopy revealed a 0.5 × 1.5-cm reddish mass on the laryngeal surface of the epiglottis. Under general anesthesia, a biopsy sample was obtained via suspension laryngoscopy. Routine pathology revealed atypical laryngeal carcinoid. Immunohistochemical staining of the sections of primary tumor was positive for cytokeratin, chromogranin A, synaptophysin, hypoxia-inducible factor-1α, P53, and CD56. GLUT-1, p-Akt, and PI3K were negative. The Ki-67 index was 15%. Supraglottic laryngectomy and selective right-neck dissection were performed. After 6 months, the patient complained of pain in the right wall of the chest; multiple cutaneous and subcutaneous nodules were evident at that site and in the abdomen. An abdominal nodule was biopsied and pathology revealed that the atypical metastatic carcinoid had metastasized to both cutaneous and subcutaneous areas of the abdomen. Chemotherapy was then prescribed. Currently, the intrathecal drug delivery system remains in place. No local recurrence has been detected. Furthermore, we systematically reviewed clinical manifestations of the disease, pathogenesis, prognostic factors, and treatment. The metastasis rate (cutaneous and subcutaneous) was approximately 12.2%. Thirty patients (62.5%) with cutaneous and subcutaneous metastases exhibited contemporaneous lymph node invasion. The 3-, 5-, and 10-year survival rates were 44.0%, 22.0%, and 13.0%, respectively.The prognosis of patients with atypical laryngeal carcinoids was poor. Relevant prognostic factors included the level of p53, human papilloma virus status, certain hypoxic markers, and distant metastasis. No optimal treatment for such metastases has yet been defined.

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Section: Discussionmentioning

confidence: 99%

“…The disease is refractory to chemotherapy, and any role for radiotherapy is controversial. 9 Thus, new treatments are required to improve long-term survival. Targeted therapies have recently been used to treat other cancers, 10,11 including NECs of other sites.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous and Subcutaneous Metastases From Atypical Laryngeal Carcinoids

Wang¹,

Jia²,

Zhou³

et al. 2016

Medicine

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“…4 Among the laryngeal neuroendocrine neoplasms, typical carcinoids are extremely rare and have the most indolent course and the best prognosis. Compared with typical carcinoids, atypical carcinoids have a more aggressive behavior and tendency to metastasize.…”

Section: Discussionmentioning

confidence: 99%

“…Chemotherapy is not an effective treatment of laryngeal atypical carcinoid tumors; however, postoperative irradiation could have a certain effect on the prevention of local recurrence. 4 The patient in the current study was treated through transoral robotic partial laryngectomy alone because the tumor-free surgical margins were confirmed using a pathologic examination.…”

Section: Discussionmentioning

confidence: 99%

“…Most occur in the supraglottic larynx, with a predilection for the aryepiglottic fold, arytenoid, and laryngeal aspect of the epiglottis. 4 They are seemingly unresponsive to chemotherapy, and the role of radiotherapy has been regarded as controversial; thus, surgery is the only effective therapeutic modality including elective neck dissection (given the 50% rate of nodal metastases). 5 In this article, we report a case of a 39-year-old woman who had an atypical carcinoid tumor on the laryngeal aspect of the epiglottis.…”

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Transoral Robotic Surgery for Atypical Carcinoid Tumor of the Larynx

Müderris¹,

Berçin²,

Sevil³

et al. 2013

Journal of Craniofacial Surgery

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In recent years, transoral robotic surgery has been introduced as an efficient and a reliable method for excision of selected oral cavity, tongue base, and supraglottic tumors in otolaryngology. In this case report, a 39-year-old woman with a history of hoarseness and dysphagia for approximately 6 months is presented. The patient was diagnosed with atypical carcinoid tumor on the laryngeal aspect of the epiglottis, and excision of the tumor was performed through transoral robotic surgery using the robotic da Vinci surgical system, a 0-degree three-dimensional endoscope, 5-mm microinstruments compatible with the da Vinci robot, and a Feyh-Kastenbauer/Weinstein-O'Malley retractor. The mass was removed completely, and no complications occurred. The patient recovered without a need for tracheotomy. Findings of the 1-year clinical follow-up revealed no locoregional recurrence or distant metastasis. This case shows, once again, that transoral robotic surgery could be used safely and effectively regardless of pathologic diagnosis in the supraglottic region tumors.

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