Transoral Robotic Surgery for Atypical Carcinoid Tumor of the Larynx

Müderris, Togay; Berçin, Sami; Sevil, Ergün; Acar, Baran; Kırış, Muzaffer

doi:10.1097/scs.0b013e3182a28c2c

Cited by 11 publications

(7 citation statements)

References 9 publications

(8 reference statements)

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“…The surgical procedures used included total and partial laryngectomy (7 cases were treated using CO 2 lasers; the others underwent robotic partial laryngectomy 48 ). As concluded by Woodruff and Senie (1991) 44 and Ferlito et al (2005, 2006), 42,45 surgery remains the mainstream treatment for atypical laryngeal carcinoid today.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, transoral robotic partial laryngectomy has become possible. 48 The principal advantages of robotic partial laryngectomy (compared to the traditional open approaches) are preservation of laryngeal function and elimination of the need for permanent tracheostomy. 48 However, such surgery is expensive and few hospitals have the sophisticated equipment required.…”

Section: Discussionmentioning

confidence: 99%

“…48 The principal advantages of robotic partial laryngectomy (compared to the traditional open approaches) are preservation of laryngeal function and elimination of the need for permanent tracheostomy. 48 However, such surgery is expensive and few hospitals have the sophisticated equipment required. Thus, CO 2 laser treatment delivered under laryngomicroscopic guidance remains the principal surgical modality for the treatment of early-stage atypical laryngeal carcinoid patients.…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous and Subcutaneous Metastases From Atypical Laryngeal Carcinoids

Wang¹,

Jia²,

Zhou³

et al. 2016

Medicine

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The incidence of cutaneous and subcutaneous metastases from atypical laryngeal carcinoids is approximately 20%. However, the pathogenesis and natural history of, and prognostic factors for, the condition remain poorly understood. We reported a 54-year-old female presented with cutaneous and subcutaneous metastases from atypical laryngeal carcinoid. Laryngoscopy revealed a 0.5 × 1.5-cm reddish mass on the laryngeal surface of the epiglottis. Under general anesthesia, a biopsy sample was obtained via suspension laryngoscopy. Routine pathology revealed atypical laryngeal carcinoid. Immunohistochemical staining of the sections of primary tumor was positive for cytokeratin, chromogranin A, synaptophysin, hypoxia-inducible factor-1α, P53, and CD56. GLUT-1, p-Akt, and PI3K were negative. The Ki-67 index was 15%. Supraglottic laryngectomy and selective right-neck dissection were performed. After 6 months, the patient complained of pain in the right wall of the chest; multiple cutaneous and subcutaneous nodules were evident at that site and in the abdomen. An abdominal nodule was biopsied and pathology revealed that the atypical metastatic carcinoid had metastasized to both cutaneous and subcutaneous areas of the abdomen. Chemotherapy was then prescribed. Currently, the intrathecal drug delivery system remains in place. No local recurrence has been detected. Furthermore, we systematically reviewed clinical manifestations of the disease, pathogenesis, prognostic factors, and treatment. The metastasis rate (cutaneous and subcutaneous) was approximately 12.2%. Thirty patients (62.5%) with cutaneous and subcutaneous metastases exhibited contemporaneous lymph node invasion. The 3-, 5-, and 10-year survival rates were 44.0%, 22.0%, and 13.0%, respectively.The prognosis of patients with atypical laryngeal carcinoids was poor. Relevant prognostic factors included the level of p53, human papilloma virus status, certain hypoxic markers, and distant metastasis. No optimal treatment for such metastases has yet been defined.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cutaneous and Subcutaneous Metastases From Atypical Laryngeal Carcinoids

Wang¹,

Jia²,

Zhou³

et al. 2016

Medicine

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“…[7] As most tumors are supraglottic in location, supraglottic laryngectomy is often performed. [8] The usual sites of metastatic involvement are lymph nodes, bones, skin, liver, and lung. Therefore, elective neck dissection is indicated.…”

Section: Discussionmentioning

confidence: 99%

Atypical carcinoid of larynx and management using transoral robotic surgery: Supraglottic laryngectomy

Dinesh

Shukla

Ranjan

et al. 2015

ASJO

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Atypical carcinoid tumor of the larynx is a particularly rare occurrence. Here, we report a patient with a laryngeal neuroendocrine tumor (NET) who was treated with transoral robotic surgery-supraglottic laryngectomy (TORS-SL). A 73-year-old male patient, a known smoker, presented with throat pain and hoarseness for 1 month. Endoscopic laryngeal examination and magnetic resonance imaging revealed a left supraglottic mass. The results of histopathologic examination and immunohistochemical analysis were consistent with atypical carcinoid tumor of the larynx. A TORS-SL was performed. There was no recurrence during a follow-up period of 18 months. NETs of the larynx are a very heterogeneous group of tumors in terms of pathological features and biological behavior. The histological diagnosis is the most important step in the management of these tumors. Tumor histology is an important determinant of prognosis. TORS-SL is a promising, minimally invasive, endoscopic surgical alternative for the treatment of supraglottic tumors with good functional and clinical outcomes as seen in this case.

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“…Most TORS for laryngeal cancer has focused on supraglottic laryngectomy (SGL) . Multiple types of tumors have been resected using this method included SCC, nerve sheath tumors , paragangliomas and carcinoid tumors . The technique follows the principles of TLM and has been described in detail .…”

Section: Types Of Operationsmentioning

confidence: 99%

Transoral robotic surgery (TORS) for laryngeal and hypopharyngeal cancers

Dziegielewski

Kang

Özer

2015

Journal of Surgical Oncology

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Transoral robotic surgery (TORS) is increasingly used in laryngeal/hypopharyngeal cancer surgery. Ablative procedures described in these anatomical sites include: (i) supraglottic laryngectomy, (ii) total laryngectomy, (iii) glottic cordectomy, and (iv) partial pharyngectomy. TORS supraglottic laryngectomy remains the most commonly performed of these procedures. Initial oncologic and functional outcomes with these procedures are promising and comparable to other treatment options. As robotic instrumentation technology advances a rise in TORS laryngeal/hypopharyngeal surgery is anticipated.

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Transoral Robotic Surgery for Atypical Carcinoid Tumor of the Larynx

Cited by 11 publications

References 9 publications

Cutaneous and Subcutaneous Metastases From Atypical Laryngeal Carcinoids

Cutaneous and Subcutaneous Metastases From Atypical Laryngeal Carcinoids

Atypical carcinoid of larynx and management using transoral robotic surgery: Supraglottic laryngectomy

Transoral robotic surgery (TORS) for laryngeal and hypopharyngeal cancers

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