Atypical anxiolytic-like response to naloxone in benzodiazepine-resistant 129S2/SvHsd mice: role of opioid receptor subtypes

Rodgers, R.J.; Augar, R.; Berryman, N.; Hansom, C. J.; O'Mahony, Megan; Palmer, Richard; Stevens, Alexander J.; Tallett, A.J.

doi:10.1007/s00213-006-0435-y

Cited by 8 publications

(4 citation statements)

References 82 publications

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“…As such, one has to think about the possibility that norBNI produces its anxiolytic effect through non-KOR mediated mechanism. This is especially important considering that antagonism of other opioid receptors has also been shown to have anxiolytic properties [61]–[64]. However, this does not appear to be the case because antagonism of mu or delta opioid receptors lasts for a few hours after norBNI administration [39], [42] while the anxiolytic profile of norBNI lasts for weeks in the present study.…”

Section: Discussionmentioning

confidence: 74%

Effects of a Post-Shock Injection of the Kappa Opioid Receptor Antagonist Norbinaltorphimine (norBNI) on Fear and Anxiety in Rats

Rogala

et al. 2012

PLoS ONE

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Exposure of rats to footshocks leads to an enduring behavioral state involving generalized fear responses and avoidance. Recent evidence suggests that the expression of negative emotional behaviors produced by a stressor is in part mediated by dynorphin and its main receptor, the kappa opioid receptor (KOR). The purpose of this study was to determine if a subcutaneous injection of the long-acting KOR antagonist norbinaltorphimine (norBNI; 15.0 and 30.0 mg/kg) given 2 days after an acute exposure of rats to footshooks (5×2 s episodes of 1.5 mA delivered over 5 min) attenuates the expression of lasting fear and anxiety. We report that exposure of rats to acute footshock produced long-lasting (>4 weeks) fear (freezing) and anxiety (avoidance of an open area in the defensive withdrawal test). The 30 mg dose of norBNI attenuated the fear expressed when shock rats were placed in the shock context at Day 9 but not Day 27 post-shock. The same dose of norBNI had no effect on the expression of generalized fear produced when shock rats were placed in a novel chamber at Days 8 and 24. In contrast, the 30 mg dose of norBNI produced consistent anxiolytic effects in shock and nonshock rats. First, the 30 mg dose was found to decrease the latency to enter the open field in the defensive withdrawal test done 30 days after the shock exposure. Second, the same high dose also had anxiolytic effects in both nonshock and shock rats as evidence by a decrease in the mean time spent in the withdrawal box. The present study shows that systemic injection of the KOR antagonist norBNI had mixed effect on fear. In contrast, norBNI had an anxiolytic effect which included the attenuation of the enhanced avoidance of a novel area produced by a prior shock experience.

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Section: Discussionmentioning

confidence: 74%

Effects of a Post-Shock Injection of the Kappa Opioid Receptor Antagonist Norbinaltorphimine (norBNI) on Fear and Anxiety in Rats

Rogala

et al. 2012

PLoS ONE

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“…2B), accompanied by restlessness with frequent short hyperactivity bouts (data not shown). While mouse naloxone data show either no effects (Belzung and Agmo, 1997a,b;Ribeiro and De Lima, 1998) or paradoxical anxiolysis (Onaivi and Martin, 1989;Rodgers et al, 2006), this drug does not affect anxiety in primates (Kalin et al, 1988) and, to the best of our knowledge, has no clinical effects on anxiety. Notably, several clinical studies have reported anxiogenic/panicogenic effects of naltrexone, another opioid receptor antagonist (Esquivel et al, 2009;Kozak et al, 2007;Maremmani et al, 1998).…”

Section: Opioidergic Systemmentioning

confidence: 85%

Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models

Stewart

Cachat

et al. 2011

Progress in Neuro-Psychopharmacology and Biological Psychiatry

209

121

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“…Whereas BALB/c mice, which are recognized for their use in cancer research, readily develop tumors in response to carcinogenic stimuli, and develop spontaneous tumors at later stages of their lifespan 29, 35–37 , C57BL/6 mice are multi-functional model organisms routinely used in studies involving infectious diseases, congenital anomalies and cancer 29, 35, 38 . 129/Sv mice on other the hand, are frequently employed in both transgenic/knockout models and oncology studies 39–41 . We evaluated a spectrum of multiple immune cell types representing both the myeloid and lymphoid lineages of hematopoietic cells in these three mouse strains and found important strain and gender-specific trends within cells of both lineages.…”

Section: Introductionmentioning

confidence: 99%

Characterization of immune cell subtypes in three commonly used mouse strains reveals gender and strain-specific variations

Hensel

Khattar

Ashton

et al. 2019

Laboratory Investigation

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The lack of consensus on bone marrow (BM) and splenic immune cell profiles in preclinical mouse strains complicates comparative analysis across different studies. Although studies have documented relative distribution of immune cells from peripheral blood in mice, similar studies for BM and spleen from naïve mice are lacking. In an effort to establish strain- and gender-specific benchmarks for distribution of various immune cell sub-types in these organs, we performed immunophenotypic analysis of BM cells and splenocytes from both genders of three commonly used murine strains (C57BL/6NCr, 129/SvHsd, and BALB/cAnNCr). Total neutrophils, and splenic macrophages were significantly higher in C57BL/6NCr; whereas total B-cells were lower. Within C57BL/6NCr female mice, BM B-cells were elevated with respect to the males whereas splenic mDCs and splenic neutrophils were reduced. Within BALB/cAnNCr male mice, BM CD4+ Tregs were elevated with respect to the other strains. Furthermore, in male BALB/cAnNCr mice, NK cells were elevated with respect to the other strains in both BM and spleen. Splenic CD4+ Tregs and splenic CD8+ T cells were reduced in male BALB/c mice in comparison to female mice. Bone marrow CD4+ T cells and mDCs were significantly increased in 129/SvHsd whereas splenic CD8+ T cells were reduced. In general, males exhibited higher immature myeloid cells, macrophages and NK cells. To our knowledge, this study provides a first attempt to systematically establish organ-specific benchmarks on immune cells in studies involving these mouse strains.

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Atypical anxiolytic-like response to naloxone in benzodiazepine-resistant 129S2/SvHsd mice: role of opioid receptor subtypes

Cited by 8 publications

References 82 publications

Effects of a Post-Shock Injection of the Kappa Opioid Receptor Antagonist Norbinaltorphimine (norBNI) on Fear and Anxiety in Rats

Effects of a Post-Shock Injection of the Kappa Opioid Receptor Antagonist Norbinaltorphimine (norBNI) on Fear and Anxiety in Rats

Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models

Characterization of immune cell subtypes in three commonly used mouse strains reveals gender and strain-specific variations

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