Atualização do consenso brasileiro no diagnóstico e tratamento da artrite reumatóide

Bértolo, Manoel Barros; Brenol, Claiton Viegas; Goldenstein-Schainberg, Cláudia; Neubarth, Fernando; Lima, Francisco Aires Corrêa; Laurindo, Iêda Maria Magalhães; Silveira, Inês Guimarães da; Pereira, Ivânio Alves; Loures, Marco Antonio Rocha; Azevedo, Mario Newton de; Freitas, Max Victor Carioca; Neto, Milton da Silveira Pedreira; Xavier, Ricardo Machado; Giorgi, Rina Dalva Neubarth; Kowalski, Sérgio Cândido; Anti, Sônia Maria Alvarenga

doi:10.1590/s0482-50042007000300003

Cited by 48 publications

(78 citation statements)

References 36 publications

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“…(1,13,14) Although many studies report the predominance of Caucasians, (15) in the present sample, African descent individuals were predominant. This finding is related to the sociodemographic characteristics of Bahia (16) and is according to the consent of the Brazilian Society of Rheumatology (1) demonstrating that RA occurs in all ethnic groups.…”

Section: Discussioncontrasting

confidence: 57%

Impact of Different Levels of Disease Activity in Painful Profile and Quality of Life in People With Rheumatoid Arthritis

Mendes

Queiroz²,

Santana³

et al. 2014

BJMHH

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Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease with impact on increasing the morbidity and mortality rates. Different levels of disease activity (LDA) have been established, however, its impact on pain and quality of life have yet to be been evidenced. The aim of this study was to evaluate the relationship of different levels of disease activity on the painful profile and quality of life (QOL) of patients diagnosed with RA. This was a cross-sectional study, conducted in RA patients attending an Educational Outpatient Care Service in Salvador, Bahia, Brazil. The LDA was defined according to values of Erythrocyte Sedimentation Rate (ESR), Visual Analog Scale (VAS), and number of swollen and sore joints, according to the Disease Activity Score in 28 joints (DAS28). Types of pain were assessed using the Douleur Neuropathique en 4 questions (DN4). To evaluate QOL, the Short Form (36) Health Survey (SF-36) and Health Assessment Questionnaire (HAQ) were applied. The association between LDA, QOL and painful profile was verified using One Way-ANOVA and Bonferroni correction post-test. A high LAD was observed in 67.7% of the 96 patients

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Section: Discussioncontrasting

confidence: 57%

Impact of Different Levels of Disease Activity in Painful Profile and Quality of Life in People With Rheumatoid Arthritis

Mendes

Queiroz²,

Santana³

et al. 2014

BJMHH

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“…The majority of selected patients (86.4%) had characteristics of poor prognosis RA, such as positive rheumatoid factor and the presence of articular erosions in X-rays of hands (Bértolo et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Quantitation of glucocorticoid receptor alpha and NF-κB pathway mRNA and its correlation with disease activity in rheumatoid arthritis patients

Cavalcante

Melo²,

Dinis³

et al. 2010

Genet. Mol. Res.

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ABSTRACT. We measured NF-κB, IKK, c-Fos, and GRα mRNA expression and in vivo glucocorticoid sensitivity in patients with rheumatoid arthritis. A very low dose intravenous dexamethasone suppression test and real-time PCR quantitation of mRNA of these genes were performed on blood samples from 21 rheumatoid arthritis patients who were not on glucocorticoids during the previous four months and on blood samples from 20 healthy individuals. Mean rheumatoid arthritis duration was 8.8 years, and mean disease activity, as assessed by Disease Activity Score 28 (DAS28), was 4.45. Basal cortisol and the percentage of cortisol reduction after the very low dose intravenous dexamethasone suppression test, as well as NF-κB, IKK, c-Fos, and GRα mRNA expression, were similar among groups. We did not observe significant correlations between glucocorticoid in vivo sensitivity and DAS28. There was a positive correlation between 2301 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 9 (4): 2300-2310 (2010) Gene expression in rheumatoid arthritis DAS28 and NF-κB, IKK, and GRα, but not c-Fos. In the multivariate analysis, only NF-κB mRNA remained as an independent variable for predicting DAS28.

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“…Type 1 diabetes can be predominantly associated with the fi rst age group, while rheumatoid arthritis and obstructive pulmonary diseases are more linked to the second group 3 . Information regarding to age has considerable limitations, because the birth date or the date of the application were not reported in 61.5% of cases.…”

Section: Discussionmentioning

confidence: 99%

Médicos, advogados e indústria farmacêutica na judicialização da saúde em Minas Gerais, Brasil

et al. 2012

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OBJECTIVE: To describe the relationship between the prescribing physician, lawyer and pharmaceutical industry in lawsuits against the state. METHODS:Retrospective descriptive study based on data from administrative fi les, relating to lawsuits involving medicine demands, in the State of Minas Gerais, from October 1999 to October 2009. The variables studied were: gender, age, benefi ciaries' illness, type of medical care (public or private), prescriber, type of legal representation and requested medication. A descriptive analysis of the variables with the distribution of frequencies was carried out. RESULTS:A total of 2,412 lawsuits were analyzed with 2,880 medicine requests, including 18 different drugs, 12 of them provided through Pharmaceutical Policies of the Brazilian National Health System (SUS). The most frequent medicines requested were adalimumab, etanercept, infl iximab, insulin glargine and tiotropium bromide. The main diseases were rheumatoid arthritis, ankylosing spondylitis, diabetes mellitus and chronic obstructive pulmonary disease. Private lawyers and doctors were predominant. The results revealed the association between doctors and law offi ces on drug requests. Among the lawsuits fi led by the offi ce A, 43.6% had a single prescriber of adalimumab, while 29 doctors were responsible for 40.2% of the same drug prescriptions. A single doctor was responsible for 16.5% of the adalimumab prescriptions, being requested through lawsuits fi led by a single private law offi ce in 44.8% of legal proceedings. CONCLUSIONS:A greater representation of doctors and lawyers from the private sector can hinder equity in health. The results revealed the association between doctors and law offi ces on drug requests. This is an indication that justice and medical practice have been used, at certain times, to serve the interests of the pharmaceutical industry. DESCRIPTORS:Health lawsuits and access to health . Equity in health. Pharmaceutical industry. Incorporation of medicines. Lawsuit offi cials. Doctors.

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Atualização do consenso brasileiro no diagnóstico e tratamento da artrite reumatóide

Cited by 48 publications

References 36 publications

Impact of Different Levels of Disease Activity in Painful Profile and Quality of Life in People With Rheumatoid Arthritis

Impact of Different Levels of Disease Activity in Painful Profile and Quality of Life in People With Rheumatoid Arthritis

Quantitation of glucocorticoid receptor alpha and NF-κB pathway mRNA and its correlation with disease activity in rheumatoid arthritis patients

Médicos, advogados e indústria farmacêutica na judicialização da saúde em Minas Gerais, Brasil

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