Attenuation of the development of hypercholesterolemic atherosclerosis by thymoquinone

Ragheb, Ahmed; Elbarbry, Fawzy; Prasad, Kailash; Mohamed, Adel; Ahmed, Mohamed S. Mohamed; Shoker, Ahmed

doi:10.1055/s-0031-1278307

Cited by 33 publications

(26 citation statements)

References 26 publications

(35 reference statements)

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“…Our results showed that protein carbonyl levels were increased significantly in EtOH-and HFD-fed rats than those in TQ-coadministered rats. It was also reported that TQ decreased the level of protein carbonyls in rats subjected to experimental atherosclerosis [35] .…”

Section: Discussionmentioning

confidence: 87%

Thymoquinone ameliorates NLRP3-mediated inflammation in the pancreas of albino Wistar rats fed ethanol and high-fat diet

Suguna

Geetha

Aruna

et al. 2015

Journal of Basic and Clinical Physiology and Pharmacology

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Section: Discussionmentioning

confidence: 87%

Thymoquinone ameliorates NLRP3-mediated inflammation in the pancreas of albino Wistar rats fed ethanol and high-fat diet

Suguna

Geetha

Aruna

et al. 2015

Journal of Basic and Clinical Physiology and Pharmacology

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“…18 Many of the biological activities have been shown to be due to TQ. A number of studies have demonstrated TQ's antioxidant 28,37 and antiinflammatory effects in the treatment of inflammatory diseases, cancer, 51 atherosclerosis, 36,41 and diabetes. 7 Various mechanisms of action have been suggested for TQ, such as inhibition of the cyclooxygenase and 5-lipoxidase pathways; suppression of the proinflammatory cytokines IL-1b and TNFa; 8 as well as augmentation of the antioxidant defense through preserving the activity of various antioxidant enzymes, such as CAT, GSH-Px, 1 and SOD.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effects of thymoquinone against spinal cord ischemia-reperfusion injury by attenuation of inflammation, oxidative stress, and apoptosis

Gökçe

Kahveci

Gökçe³

et al. 2016

SPI

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OBJECTIVE Ischemia-reperfusion (I/R) injury of the spinal cord following thoracoabdominal aortic surgery remains the most devastating complication, with a life-changing impact on the patient. Thymoquinone (TQ), the main constituent of the volatile oil from Nigella sativa seeds, is reported to possess strong antioxidant, antiinflammatory, and antiapoptotic properties. This study investigated the effects of TQ administration following I/R injury to the spinal cord. METHODS Thirty-two rats were randomly allocated into 4 groups. Group 1 underwent only laparotomy. For Group 2, aortic clip occlusion was introduced to produce I/R injury. Group 3 was given 30 mg/kg of methylprednisolone intraperitoneally immediately after the I/R injury. Group 4 was given 10 mg/kg of TQ intraperitoneally for 7 days before induction of spinal cord I/R injury, and administration was continued until the animal was euthanized. Locomotor function (Basso, Beattie, and Bresnahan scale and inclined plane test) was assessed at 24 hours postischemia. Spinal cord tissue samples were harvested to analyze tissue concentrations of malondialdehyde, nitric oxide, tumor necrosis factor–α, interleukin-1, superoxide dismutase, glutathione-peroxidase, catalase, and caspase-3. In addition, histological and ultrastructural evaluations were performed. RESULTS Thymoquinone treatment improved neurological outcome, which was supported by decreased levels of oxidative products (malondialdehyde and nitric oxide) and proinflammatory cytokines (tumor necrosis factor–α and interleukin-1), increased activities of antioxidant enzymes (superoxide dismutase, glutathione-peroxidase, and catalase), as well as reduction of motor neuron apoptosis. Light microscopy and electron microscopy results also showed preservation of tissue structure in the treatment group. CONCLUSIONS As shown by functional, biochemical, histological, and ultrastructural analysis, TQ exhibits an important protective effect against I/R injury of the spinal cord.

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“…Thymoquinone administration twice daily has also been effective on lipid profile modifying in hyperlipidemic rats [49]. In a similar study on hypercholesterolemic rabbits, thymoquinone significantly reduced TC and LDL-C concentrations at two different doses of 10 mg/ kg/day and 20 mg/kg/day following 8 weeks of treatment [50]. Asgary et al conducted a study on hypercholesterolemic rabbits that were treated with NS seed powder.…”

Section: Animal Studiesmentioning

confidence: 99%

Ameliorative effects of Nigella sativa on dyslipidemia

Asgary

Sahebkar

Goli-malekabadi

2015

J Endocrinol Invest

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Attenuation of the development of hypercholesterolemic atherosclerosis by thymoquinone

Cited by 33 publications

References 26 publications

Thymoquinone ameliorates NLRP3-mediated inflammation in the pancreas of albino Wistar rats fed ethanol and high-fat diet

Thymoquinone ameliorates NLRP3-mediated inflammation in the pancreas of albino Wistar rats fed ethanol and high-fat diet

Neuroprotective effects of thymoquinone against spinal cord ischemia-reperfusion injury by attenuation of inflammation, oxidative stress, and apoptosis

Ameliorative effects of Nigella sativa on dyslipidemia

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