Thymoquinone ameliorates NLRP3-mediated inflammation in the pancreas of albino Wistar rats fed ethanol and high-fat diet

Suguna, Periyanayagam; Geetha, A; Aruna, Ravikumar; Ganesan, Vijaiyan Siva

doi:10.1515/jbcpp-2014-0109

Cited by 16 publications

(16 citation statements)

References 43 publications

(40 reference statements)

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“…In the current study, thymoquinone treatment significantly suppressed the TNF-α and IL-6 levels in DM rats. Periyanayagam et al (27) observed that thymoquinone ameliorates NLRP3-induced inflammation in albino Wistar rats administered with ethanol and fed a high-fat diet. Rifaioglu et al (28) demonstrated that thymoquinone has an antioxidative and anti-inflammatory effect in an acute pseudomonas prostatitis rat model.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of thymoquinone improves cardiovascular function, and attenuates oxidative stress, inflammation and apoptosis by mediating the PI3K/Akt pathway in diabetic rats

Liu

2016

Molecular Medicine Reports

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Thymoquinone is the main active monomer extracted from black cumin and has anti‑inflammatory, antioxidant and anti‑apoptotic functions. However, the protective effects of thymoquinone on cardiovascular function in diabetes remain to be fully elucidated. The present study aimed to investigate the molecular mechanisms underling the beneficial effects of thymoquinone on the cardiovascular function in streptozotocin‑induced diabetes mellitus (DM) rats. Supplement thymoquinone may recover the insulin levels and body weight, inhibit blood glucose levels and reduce the heart rate in DM‑induced rats. The results indicated that the heart, liver and lung to body weight ratios, in addition to the blood pressure levels, were similar for each experimental group. Treatment with thymoquinone significantly reduced oxidative stress damage, inhibited the increased endothelial nitric oxide synthase protein expression and suppressed the elevation of cyclooxygenase‑2 levels in DM‑induced rats. In addition, thymoquinone significantly suppressed the promotion of tumor necrosis factor‑α and interleukin‑6 levels in the DM‑induced rats. Furthermore, administration of thymoquinone significantly reduced caspase‑3 activity and the promotion of phosphorylated‑protein kinase B (Akt) protein expression levels in DM‑induced rats. These results suggest that the protective effect of thymoquinone improves cardiovascular function and attenuates oxidative stress, inflammation and apoptosis by mediating the phosphatidylinositol 3‑kinase/Akt pathway in DM‑induced rats.

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Section: Discussionmentioning

confidence: 99%

Protective effect of thymoquinone improves cardiovascular function, and attenuates oxidative stress, inflammation and apoptosis by mediating the PI3K/Akt pathway in diabetic rats

Liu

2016

Molecular Medicine Reports

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“…Furthermore, upon SARS-CoV-2 entry into the host cell, the disruption of the intracellular environment via ion redistribution results in the activation of NLRP3 inflammasome that increases the secretion of proinflammatory cytokines: IL-1β, IL-18, IL-6 and TNF, further contributing to the imminent cytokine storm and tissue inflammation during respiratory illness [266]. In this context, TQ could have a promising anti-inflammatory role, where it significantly decreases the mRNA expression of the aforementioned proinflammatory cytokines, IL-18, IL-1β and TNF-α, and inhibits IL-6-signaling [16,17,[267][268][269]. In cancer patients, inflammasomes are also overexpressed, leading to an increased inflammatory status [270,271].…”

Section: The Significance Of Thymoquinone In Other Pathological Processes In Covid-cancer Patientsmentioning

confidence: 99%

Thymoquinone: A Tie-Breaker in SARS-CoV2-Infected Cancer Patients?

Elgohary

Elkhodiry

Amin

et al. 2021

Cells

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Since the beginning of the SARS-CoV-2(severe acute respiratory syndrome-coronavirus-2) pandemic, arace to develop a vaccine has been initiated, considering the massive and rather significant economic and healthcare hits that this virus has caused. The pathophysiology occurring following COVID-19(coronavirus disease-2019) infection has givenhints regarding the supportive and symptomatic treatments to establish for patients, as no specific anti-SARS-CoV-2 is available yet. Patient symptoms vary greatly and range from mild symptoms to severe fatal complications. Supportive treatments include antipyretics, antiviral therapies, different combinations of broad-spectrum antibiotics, hydroxychloroquine and plasma transfusion. Unfortunately, cancer patients are at higher risk of viral infection and more likely to develop serious complications due to their immunocompromised state, the fact that they are already administering multiple medications, as well as combined comorbidity compared to the general population. It may seem impossible to find a drug that possesses both potent antiviral and anticancer effects specifically against COVID-19 infection and its complications and the existing malignancy, respectively. Thymoquinone (TQ) is the most pharmacologically active ingredient in Nigella sativa seeds (black seeds); it is reported to have anticancer, anti-inflammatory and antioxidant effects in various settings. In this review, we will discuss the multiple effects of TQ specifically against COVID-19, its beneficial effects against COVID-19 pathophysiology and multiple-organ complications, its use as an adjuvant for supportive COVID-19 therapy and cancer therapy, and finally, its anticancer effects.

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“…The tail was employed to inject B16F10 cells, and pulmonary tumor lump production was employed as an outcome measure. Thymoquinone dose-dependently attenuated nodules from 15 to 1 in this model [ 183 ].…”

Section: Inhibitors Of Nlrp3 Inflammasome-driven In Vivo Disease Modelsmentioning

confidence: 99%

“…Thymoquinone has been probed for its NLRP3 related actions on pancreatitis [ 183 ]. Upon thymoquinone exposure (100 mg/kg p.o.…”

Section: Inhibitors Of Nlrp3 Inflammasome-driven In Vivo Disease Modelsmentioning

confidence: 99%

Promise of the NLRP3 Inflammasome Inhibitors in In Vivo Disease Models

et al. 2021

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Nucleotide-binding oligomerization domain NOD-like receptors (NLRs) are conserved cytosolic pattern recognition receptors (PRRs) that track the intracellular milieu for the existence of infection, disease-causing microbes, as well as metabolic distresses. The NLRP3 inflammasome agglomerates are consequent to sensing a wide spectrum of pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs). Certain members of the NLR family have been documented to lump into multimolecular conglomerates called inflammasomes, which are inherently linked to stimulation of the cysteine protease caspase-1. Following activation, caspase-1 severs the proinflammatory cytokines interleukin (IL)-1β and IL-18 to their biologically active forms, with consequent commencement of caspase-1-associated pyroptosis. This type of cell death by pyroptosis epitomizes a leading pathway of inflammation. Accumulating scientific documentation has recorded overstimulation of NLRP3 (NOD-like receptor protein 3) inflammasome involvement in a wide array of inflammatory conditions. IL-1β is an archetypic inflammatory cytokine implicated in multiple types of inflammatory maladies. Approaches to impede IL-1β’s actions are possible, and their therapeutic effects have been clinically demonstrated; nevertheless, such strategies are associated with certain constraints. For instance, treatments that focus on systemically negating IL-1β (i.e., anakinra, rilonacept, and canakinumab) have been reported to result in an escalated peril of infections. Therefore, given the therapeutic promise of an NLRP3 inhibitor, the concerted escalated venture of the scientific sorority in the advancement of small molecules focusing on direct NLRP3 inflammasome inhibition is quite predictable.

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Thymoquinone ameliorates NLRP3-mediated inflammation in the pancreas of albino Wistar rats fed ethanol and high-fat diet

Abstract: TQ exerts the anti-inflammatory activity probably by downregulating the ASC expression to minimize the maturation of proinflammatory cytokines.

Cited by 16 publications

References 43 publications

Protective effect of thymoquinone improves cardiovascular function, and attenuates oxidative stress, inflammation and apoptosis by mediating the PI3K/Akt pathway in diabetic rats

Protective effect of thymoquinone improves cardiovascular function, and attenuates oxidative stress, inflammation and apoptosis by mediating the PI3K/Akt pathway in diabetic rats

Thymoquinone: A Tie-Breaker in SARS-CoV2-Infected Cancer Patients?

Promise of the NLRP3 Inflammasome Inhibitors in In Vivo Disease Models

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