Attenuation of isoprenaline-induced myocardial infarction by Rheum turkestanicum

Hossini, Azar; Rajabian, Arezoo; Sobhanifar, Mohammad-Ali; Alavi, Mohaddeseh Sadat; Taghipour, Zahra; Hasanpour, Maede; Iranshahi, Mehrdad; Boroumand-Noughabi, Samaneh; Banach, Maciej; Sahebkar, Amirhossein

doi:10.1016/j.biopha.2022.112775

Cited by 16 publications

(10 citation statements)

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“… Chromatogram and corresponding mass adducts which was reported in our recent work ( Hossini et al, 2022 ). (A) The total ion chromatogram of R.turkestanicum using LC-MS in the positive mode.…”

Section: Resultsmentioning

confidence: 86%

“…Our findings also support that R. turkestanicum protects against doxorubicin-induced cardiotoxicity by restoring cellular antioxidant defenses and as an antioxidant in various cells and toxicity models ( Hosseini et al, 2018 ; Boroushaki et al, 2019a ; Boroushaki et al, 2019b ; Hosseini et al, 2020 ). The protection by the plant is also associated with improvements in LDH and creatinine phosphokinase activities ( Hosseini et al, 2017 ; Hossini et al, 2022 ). The protective effect of R. turkestanicum observed in our study is potentially attributed to the presence of specific plant bioactives.…”

Section: Discussionmentioning

confidence: 99%

“…Doxorubicin was administrated i. p. at a dose of 2.5 mg/kg in 6 equal injections for 2 weeks to create a cumulative dose (15 mg/kg body weight) ( Arafa et al, 2014 ). Groups 3 and 4 received R. turkestanicum at doses of 100 and 300 mg/kg ( Hosseini et al, 2017 ; Jahani Yazdi et al, 2020 ; Hossini et al, 2022 ) as i. p. one week after doxorubicin administration. R. turkestanicum was injected at a dose of 300 mg/kg to rats in the fifth group without administration of doxorubicin.…”

Section: Methodsmentioning

confidence: 99%

“…According to our previous study, the LC-MS analysis was performed using an AB SCIEX QTRAP (Shimadzu) liquid chromatography coupled with a triple quadrupole mass spectrometer ( Hossini et al, 2022 ). Liquid chromatography separation was performed on a Supelco C18 (15 mm × 2.1 mm × 3 μm) column.…”

Section: Methodsmentioning

confidence: 99%

“…One recent study showed R. turkestanicum reduced doxorubicin-induced toxicity in cardiomyocytes (H9c2 cell line) via modulation of oxidative stress ( Hosseini and Rajabian, 2016 ). Also In another study cardioprotective effect of R. turkestanicum against isoprenaline was evaluated which showed anti-oxidant activity of extract reduced isoprenaline-induced cardiac toxicity ( Hossini et al, 2022 ) In the current study, we have evaluated the cardioprotective effects of R. turkestanicum against doxorubicin-induced cardiotoxicity in an animal model.…”

Section: Introductionmentioning

confidence: 99%

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Cardioprotective Effect of Rheum turkestanicum Against Doxorubicin-Induced Toxicity in Rats

et al. 2022

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Background: Doxorubicin as an anti-cancer drug causes cardiotoxicity, limiting its tolerability and use. The mechanism of toxicity is due to free radical production and cardiomyocytes injury. This research evaluated Rheum turkestanicum (R.turkestanicum) extract against doxorubicin cardiotoxicity due to its considerable in vitro antioxidant activity.Methods: Male Wistar rats received 2.5 mg/kg doxorubicin intraperitoneally every other day for 2 weeks to create an accumulative dose. R. turkestanicum was administrated at a dose of 100 and 300 mg/kg intraperitoneally from the second week for 7 days. On the 15th day, the animals were anesthetized and blood was collected from cardiac tissue for evaluation of alanine aminotransferase (ALT), cardiac muscle creatinine kinase (CK-MB), troponin T (cTn-T), lactate dehydrogenase (LDH), and B-type natriuretic peptide brain natriuretic peptide. A cardiac homogenate was also collected to determine superoxide dismutase (SOD), catalase Catalase Activity, malondialdehyde (MDA), and thiols. Histopathology was also performed.Results: Doxorubicin increased all cardiac enzymes and malondialdehyde, correlating with a reduction in SOD, catalase, and thiols. Histopathology revealed extracellular edema, moderate congestion, and hemorrhage of foci. In contrast, administration of R. turkestanicum ameliorated these doxorubicin-induced pathophysiological changes.Conclusion: This study revealed that the extract ameliorated doxorubicin-induced cardiac toxicity via modulation of oxidative stress-related pathways. Liquid chromatography-mass spectrometry analysis of R. turkestanicum indicated several components with potent pharmacological properties.

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Section: Resultsmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cardioprotective Effect of Rheum turkestanicum Against Doxorubicin-Induced Toxicity in Rats

et al. 2022

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Protective effects of 3, 4‐dihydroxybenzoic acid on myocardial infarction induced by isoproterenol in rats

Vincent,

Stanely,

Ponnian

2024

J Biochem & Molecular Tox

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Despite considerable advances in interventions and treatment, there is a high mortality rate in patients with myocardial infarction (MI). This is the first study to investigate the protective effects of 3, 4‐dihydroxybenzoic acid against isoproterenol induced MI in rats. MI was induced by isoproterenol (100‐mg/kg body weight) in rats. Then, rats were treated with 3, 4‐dihydroxybenzoic acid (16‐mg/kg body weight) for 2 weeks. Serum creatine kinase‐MB, cardiac troponin‐T, cardiac troponin‐I, and heart thiobarbituric acid reactive substances were significantly (p < 0.05) increased and heart superoxide dismutase and catalase activities were significantly (p < 0.05) reduced in isoproterenol‐induced myocardial infarcted rats. Isoproterenol induction significantly (p < 0.05) elevated the plasma homocysteine and serum high sensitivity‐C‐reactive protein levels. Furthermore, an enzyme‐linked immunosorbent assay, reverse transcription polymerase chain study, and immunohistochemical (IHC) staining revealed significantly (p < 0.05) elevated levels and expression of serum/myocardial nuclear factor‐κB, tumor necrosis factor‐alpha, interleukin‐1 beta, and Interleukin‐6 and significantly (p < 0.05) reduced levels/expression of serum/myocardial interleukin‐10 in myocardial infarcted rats. Nevertheless, isoproterenol‐induced rats treated with 3, 4‐dihydroxybenzoic acid considerably (p < 0.05) attenuated all the biochemical, molecular, and IHC parameters investigated and inhibited oxidative stress and inflammation and protected the heart, through its antioxidant and anti‐inflammatory mechanisms.

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Phytoconstituents with cardioprotective properties: A pharmacological overview on their efficacy against myocardial infarction

Ullah,

Mostafa,

Halim

et al. 2024

Phytotherapy Research

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Myocardial infarction (MI) is considered one of the most common cardiac diseases and major cause of death worldwide. The prevalence of MI and MI‐associated mortality have been increasing in recent years due to poor lifestyle habits viz. residency, obesity, stress, and pollution. Synthetic drugs for the treatment of MI provide good chance of survival; however, the demand to search more safe, effective, and natural drugs is increasing. Plants provide fruitful sources for powerful antioxidant and anti‐inflammatory agents for prevention and/or treatment of MI. However, many plant extracts lack exact information about their possible dosage, toxicity and drug interactions which may hinder their usefulness as potential treatment options. Phytoconstituents play cardioprotective role by either acting as a prophylactic or adjuvant therapy to the concurrently used synthetic drugs to decrease the dosage or relief the side effects of such drugs. This review highlights the role of different herbal formulations, examples of plant extracts and types of several isolated phytoconstituents (phenolic acids, flavonoids, stilbenes, alkaloids, phenyl propanoids) in the prevention of MI with reported activities. Moreover, their possible mechanisms of action are also discussed to guide future research for the development of safer substitutes to manage MI.

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Attenuation of isoprenaline-induced myocardial infarction by Rheum turkestanicum

Cited by 16 publications

References 30 publications

Cardioprotective Effect of Rheum turkestanicum Against Doxorubicin-Induced Toxicity in Rats

Cardioprotective Effect of Rheum turkestanicum Against Doxorubicin-Induced Toxicity in Rats

Protective effects of 3, 4‐dihydroxybenzoic acid on myocardial infarction induced by isoproterenol in rats

Phytoconstituents with cardioprotective properties: A pharmacological overview on their efficacy against myocardial infarction

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