Attenuation of Fatty Liver and Prevention of Hypercholesterolemia by Extract of Curcuma longa through Regulating the Expression of CYP7A1, LDL‐Receptor, HO‐1, and HMG‐CoA Reductase

Abstract

Turmeric may be considered a functional food for regulating plasma cholesterol levels and preventing the development of fatty liver in people who frequently consume a high-cholesterol diet.

<i>Olea europaea</i> Linn (Oleaceae) Fruit Pulp Exhibits Hypocholesterolemic and Hepatoprotective Effects via Regulation of Peroxisome Proliferation-Activated Receptor Alpha in High-Fat Diet-Fed Rats

“…Levels of TC and LDL were elevated, whereas HDL was lowered as a result of consuming HFD for 28 days. Our results are consistent with previous findings with similar experimental settings as there was no significant difference on plasma TG among various groups [18,19]. The supplementation of a high dose of OFP-EA extract (300 mg/kg) significantly altered the abnormal plasma lipid level induced by HFD.…”

“…The expression level of CYP7A1 was shown to be up-regulated by high plasma cholesterol, suggesting that the synthesis of bile acid is positively dependent on plasma cholesterol level [19]. In this study, the increased CYP7A1 protein expression in hypercholesterolemic rats was attenuated dose dependently by OFP-EA-extract treatment.…”

The Effect of Sauropus Androgynus Leaves Extract Plus Turmeric Powder on Fat Deposition, Carcass Quality and Blood Profile in Broilers Fed Low Protein Diets

“…Napirah (2013) also reported that 1% turmeric supplementation tended to reduce meat fat and cholesterol content in quail. Yiu et al (2011) turmeric supplementation increased cholesterol 7 α-hydroxylase, hemeoxygenase 1 and low-density lipoprotein receptors.…”

Effect of tetrahydrocurcumin on the profiles of drug-metabolizing enzymes induced by a high fat and high fructose diet in mice

“…Moreover, THC exhibited antioxidant activities in several models [11][12][13]. In a previous study, Naito et al [8] found that the Table 1 TaqMan Ò Gene Expression detection and SYBR Ò Green I-PCR primers (modified from [16]).…”

“…Abbreviations: BSA, bovine serum albumin; CYP, cytochrome P450; DAB, 3, 3 0 -diaminobenzidine; H&E, hematoxylin and eosin; HFD, high fat and high fructose diet; NAFLD, non-alcoholic fatty liver disease; PBS, phosphate buffered saline; RD, commercial regular diet; THC, tetrahydrocurcumin; vitE, vitamin E. with protective effects against inflammation and obesity-related insulin resistance, hepatic steatosis, and DM [11][12][13]. However, THC may potentially interfere with the regulatory mechanisms of CYP expression.…”