&lt;i&gt;Olea europaea&lt;/i&gt; Linn (Oleaceae) Fruit Pulp Exhibits Hypocholesterolemic and Hepatoprotective Effects via Regulation of Peroxisome Proliferation-Activated Receptor Alpha in High-Fat Diet-Fed Rats

Kim, Moo-Sung; Koppula, Sushruta; Sung, Soo-Jin; Lee, Sang-Rin; Lee, Kyung-Ae; Park, Tae-Kyu; Kang, Hunseung

doi:10.4314/tjpr.v13i1.5

Cited by 9 publications

(5 citation statements)

References 34 publications

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“…Data for vLDL values as a result of treatments of supplementation of olive pomace in rats nutrition, increased from 19.2mg/ dl of normal nutrition to 19.4, 19.6, 19.69 and 19.72mg/dl, at treatments 2.5, 5, 7.5 and 10% of olive pomace in rats nutrition when supplemented in prepared biscuit, respectively. Obtained data are in agreement with those by Kim et al (2014) who found an effect of Olea europea-ethyl acetate (Oleaceae) fruit pomace (Oleaceae) extract on plasma lipid levels (TC, TG, HDL and LDL), of rats after administering a dose of 100mg/kg, to be 5. 45, 0.65, 8.74 and 0.59(mM), respectively.While, plasma lipid levels of normal control were1.73, 0.70, 0.40 and 0.91(mM), respectively.…”

Section: Effect On Hdl Ldl and Vldl-cholesterolsupporting

confidence: 81%

The Effects of Supplemented Biscuit with Different Levels of Olive Pomace on Feeding Diabetic Rats

Elkotb

Elsanat

Saleh

2017

Journal of Sustainable Agricultural Sciences

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THIS WORK was conducted to study the effects of different levels of olive pomace (OP) on body weight gain, feed intake and feed conversion efficiency of rats. Experimental rats nutrition supplemented to diabetic rats (7 rats in each group) for 42 day. After the 42 nd day, chemical analysis of marker enzyme (MDA, TAC and SOD), liver function (ALT, AST and T-protein), kidney functions (Creatinine and Blood urea), lipid profile (triglycerides, total cholesterol, HDL, LDL and vLDL), and haematological analysis was recorded. The highest effects of supplementation of olive pomace in rats nutrition on body weight of rats, were 200, 200, 205 and 225 g, of treatments (2.5, 5, 7.5 and 10% of OP), respectively as compared with normal control (0 % OP), which was 190 g. Also, the most effective treatments were 10% of OP of blood biochemical and haematological parameters, comparing with normal nutrition. Therefore, it is recommended to add olive pomace at 5%, 7.5% and 10% in rats nutrition to improve performance and health.

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Section: Effect On Hdl Ldl and Vldl-cholesterolsupporting

confidence: 81%

The Effects of Supplemented Biscuit with Different Levels of Olive Pomace on Feeding Diabetic Rats

Elkotb

Elsanat

Saleh

2017

Journal of Sustainable Agricultural Sciences

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“…The oleuropein showed a better docking score from the known inhibitor (TEI-6720) of XO protein, and chlorogenic acid showed a redocking score near to the known anti-cholesterol drug Atorvastatin. Other studies, which showed the anti-hypercholesterolemic effect of chlorogenic acid [76][77][78], support the present research findings. In conclusion, this study demonstrated the potential of two natural products, i.e., Coffea arabica L. oil and Olea europaea L. oil, for treating malathion poisoning as they are antioxidants in nature.…”

Section: Discussionsupporting

confidence: 92%

Alleviation of Malathion Toxicity Effect by Coffea arabica L. Oil and Olea europaea L. Oil on Lipid Profile: Physiological and In Silico Study

Al-Asmari

Zeid

Altayb

et al. 2021

Plants

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The community health plans commonly use malathion (MAL), an organophosphate pesticide (OP), to eliminate pathogenic insects. The objective of the present research is to evaluate the consequences of Coffea arabica L. oil and Olea europaea L. oil on MAL-intoxicated male rats. Six equal groups of animals were used for conducting this study (n = 10). Animals in group one were designated as control, animals belonging to group two were exposed to MAL in the measure of hundred mg per kg BW (body weight) for forty-nine days (seven weeks), rats in the third and fourth groups were administered with 400 mg/kg BW of Coffea arabica L. and Olea europaea L. oils, respectively, and the same amount of MAL as given to the second group. Groups five and six were administered with the same amount of Coffea arabica L. oil and Olea europaea L. oil as given to group three. Exposure of rats to 100 mg/kg body weight of MAL resulted in statistical alteration of the serum lipid profile. A marked decline was noticed in the severe changes of these blood parameters when MAL-intoxicated rats were treated with Coffea arabica L. oil and Olea europaea L. oil. Two compounds from Coffea arabica L. oil (Chlorogenic acid) and Olea europaea L. oil (Oleuropein) demonstrated good interaction with xanthine oxidase (XO) and 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) enzymes that are associated with cholesterol production. The present study indicated that Coffea arabica L. oil and Olea europaea L. oil could be considered prospective and potential healing agents against metabolic conditions induced by MAL.

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“…Olives ( Olea europaea L.) are considered a representative element in Mediterranean diets, either as such or processed into olive oil; a significant literature documents their beneficial effects on human health [ 39 ]. Kim et al [ 40 ] fed male Sprague-Dawley rats a control diet (10% fat), an HFD (5.5% oil, 1% cholic acid and 2% cholesterol) and an HFD and olive fruit pulp ethyl acetate extract (100 or 300 mg/kg BW, by oral gavage) for 28 days. Treatments suppressed an increase in serum TC and LDL, but without returning their values to control levels.…”

Section: Effect Of Polyphenolic Compounds From Different Sources Omentioning

confidence: 99%

Modulation of PPAR Expression and Activity in Response to Polyphenolic Compounds in High Fat Diets

Domínguez-Ávila

González‐Aguilar

́Álvarez-Parrilla

et al. 2016

IJMS

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Peroxisome proliferator-activated receptors (PPAR) are transcription factors that modulate energy metabolism in liver, adipose tissue and muscle. High fat diets (HFD) can negatively impact PPAR expression or activity, favoring obesity, dyslipidemia, insulin resistance and other conditions. However, polyphenols (PP) found in vegetable foodstuffs are capable of positively modulating this pathway. We therefore focused this review on the possible effects that PP can have on PPAR when administered together with HFD. We found that PP from diverse sources, such as coffee, olives, rice, berries and others, are capable of inducing the expression of genes involved in a decrease of adipose mass, liver and serum lipids and lipid biosynthesis in animal and cell models of HFD. Since cells or gut bacteria can transform PP into different metabolites, it is possible that a synergistic or antagonistic effect ultimately occurs. PP molecules from vegetable sources are an interesting option to maintain or return to a state of energy homeostasis, possibly due to an adequate PPAR expression and activity.

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<i>Olea europaea</i> Linn (Oleaceae) Fruit Pulp Exhibits Hypocholesterolemic and Hepatoprotective Effects via Regulation of Peroxisome Proliferation-Activated Receptor Alpha in High-Fat Diet-Fed Rats

Cited by 9 publications

References 34 publications

The Effects of Supplemented Biscuit with Different Levels of Olive Pomace on Feeding Diabetic Rats

The Effects of Supplemented Biscuit with Different Levels of Olive Pomace on Feeding Diabetic Rats

Alleviation of Malathion Toxicity Effect by Coffea arabica L. Oil and Olea europaea L. Oil on Lipid Profile: Physiological and In Silico Study

Modulation of PPAR Expression and Activity in Response to Polyphenolic Compounds in High Fat Diets

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