Attenuated Total Reflectance Fourier Transformation Infrared spectroscopy fingerprinted online monitoring of the kinetics of circulating Butyrylcholinesterase enzyme during metabolism of bambuterol

Eid, Sherif M.; El-Rahman, Mohamed K. Abd; Elghobashy, Mohamed R.; Kelani, Khadiga M.

doi:10.1016/j.aca.2017.12.011

Cited by 23 publications

(12 citation statements)

References 51 publications

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“…ATR-FTIR spectroscopy is a well established tactic in literature that has several applications for qualitative and quantitative analysis of different samples and structurally related compounds [32,33]. The structural transformations of geraniol oil, plain formula (F3, the same components without adding geraniol oil), and the optimal polymeric mixed micelles formula (F3) were investigated by FTIR spectroscopy using an IRAFFINITY-1 FTIR device (Shimadzu, Kyoto, Japan).…”

Section: Fourier Transform Infrared Spectroscopy (Ftir)mentioning

confidence: 99%

Novel Intranasal Drug Delivery: Geraniol Charged Polymeric Mixed Micelles for Targeting Cerebral Insult as a Result of Ischaemia/Reperfusion

et al. 2020

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Brain damage caused by cerebral ischaemia/reperfusion (I/R) can lead to handicapping. So, the present study aims to evaluate the prophylactic and therapeutic effects of geraniol in the form of intranasal polymeric mixed micelle (PMM) on the central nervous system in cerebral ischaemia/reperfusion (I/R) injury. A 32 factorial design was used to prepare and optimize geraniol PMM to investigate polymer and stabilizer different concentrations on particle size (PS) and percent entrapment efficiency (%EE). F3 possessing the highest desirability value (0.96), with a PS value of 32.46 ± 0.64 nm, EE of 97.85 ± 1.90%, and release efficiency of 59.66 ± 0.64%, was selected for further pharmacological and histopathological studies. In the prophylactic study, animals were classified into a sham-operated group, a positive control group for which I/R was done without treatment, and treated groups that received vehicle (plain micelles), geraniol oil, and geraniol micelles intranasally before and after I/R. In the therapeutic study, treated rats received geraniol oil and micelles after I/R. Evaluation of the effect of geraniol on behavior was done by activity cage and rotarod and the analgesic effect tested by hot plate. Anti-inflammatory activity was assessed by measuring interleukin β6, cyclooxygenase-2, hydrogen peroxide, and inducible nitric oxide synthase. Histopathogical examination of cerebral cortices was also done to confirm the results of a biochemical assay. Geraniol nanostructured polymeric mixed micelles showed an enhanced neuro-protective effect compared to geraniol oil, confirming that PMM via intranasal route could be an efficient approach for delivering geraniol directly to the brain through crossing the blood–brain barrier.

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Section: Fourier Transform Infrared Spectroscopy (Ftir)mentioning

confidence: 99%

Novel Intranasal Drug Delivery: Geraniol Charged Polymeric Mixed Micelles for Targeting Cerebral Insult as a Result of Ischaemia/Reperfusion

et al. 2020

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“…The field-moist soil samples were scanned using an Agilent 4300 handheld Fourier transfer infrared (FTIR) spectrometer (Agilent Technologies, Santa Clara, CA, United States), with spectral wavenumber range of 4000 cm −1 to 650 cm −1 at 8 cm− 1 resolution and~2 cm −1 sampling interval. The instrument was equipped with a deuterated triglycine sulfate (DTGS) thermal detector, and a zinc selenide (ZnSe) beam splitter which has high mid-infrared throughput and a wide spectral range (Eid et., 2018). This detector relies on only the amount of heat energy delivered, and its response is independent of wavelength and provides slow and linear response over a very wide range of FT-IR throughput (Theocharous and Birch, 2006).…”

Section: Mir Spectra Collection and Pre-processingmentioning

confidence: 99%

The application of a handheld mid-infrared spectrometry for rapid measurement of oil contamination in agricultural sites

Douglas

Nawar

Alamar

et al. 2019

Science of The Total Environment

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Rapid analysis of oil-contaminated soils is important to facilitate risk assessment and remediation decision-making process. This study reports on the potential of a handheld midinfrared (MIR) spectrometer for the prediction of total petroleum hydrocarbons (TPH), including aliphatic (alkanes) and polycyclic aromatic hydrocarbons (PAH) in limited number of fresh soil samples. Partial least squares regression (PLSR) and random forest (RF) modelling techniques were compared for the prediction of alkanes, PAH, and TPH concentrations in soil samples (n = 85) collected from three contaminated sites located in the Niger Delta, Southern Nigeria. Results revealed that prediction of RF models outperformed the PLSR with coefficient of determination (R 2) values of 0.80, 0.79 and 0.72, residual prediction deviation (RPD) values of 2.35, 1.96, and 2.72, and root mean square error of prediction (RMSEP) values of 63.80, 83.0 and 65.88 mg kg-1 for TPH, alkanes, and PAH, respectively. Considering the limited dataset used in the independent validation (18 samples), accurate predictions were achieved with RF for PAH and TPH, while the prediction for alkanes was less accurate. Therefore, results suggest that RF

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“…It can make concentration predictions even in the presence of interfering compounds. 17 Also, the direct application of urine samples to the surface of the ATR prism as a sampling technique is sufficient for the quantitative determination of the early-stage malaria parasite, 18 enzyme kinetics parameters, 19 biomarkers of glomerulonephritis, 20 tumor cells, 21 and malignant ovarian tissues. 22 A recent study compared the performances of micro-ATR-FTIR and GC-MS as identifying tools for micro-plastics and bers isolated from different water sources.…”

Section: Introductionmentioning

confidence: 99%

Chemical fingerprinting and quantitative monitoring of the doping drugs bambuterol and terbutaline in human urine samples using ATR-FTIR coupled with a PLSR chemometric tool

et al. 2020

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Attenuated Total Reflectance Fourier Transformation Infrared spectroscopy fingerprinted online monitoring of the kinetics of circulating Butyrylcholinesterase enzyme during metabolism of bambuterol

Cited by 23 publications

References 51 publications

Novel Intranasal Drug Delivery: Geraniol Charged Polymeric Mixed Micelles for Targeting Cerebral Insult as a Result of Ischaemia/Reperfusion

Novel Intranasal Drug Delivery: Geraniol Charged Polymeric Mixed Micelles for Targeting Cerebral Insult as a Result of Ischaemia/Reperfusion

The application of a handheld mid-infrared spectrometry for rapid measurement of oil contamination in agricultural sites

Chemical fingerprinting and quantitative monitoring of the doping drugs bambuterol and terbutaline in human urine samples using ATR-FTIR coupled with a PLSR chemometric tool

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