Atrophie Blanche: Periodic Painful Ulcers of Lower Extremities

Atrophie blanche

“…Drugs that influence coagulation and fibrinolysis have been used since Gray et al . 16 and Potter and Haeberlin 46 in the 1960s suggested that local thrombo‐occlusive processes were the cause of the ulcers that appeared in AB.…”

“…Women are more often affected than men; the male to female ratio is 1 : 4. 10 , 16 AB lesions can occur at any age, but the peak incidence ranges from 30 to 60 years. 3 , 16–18 AB has also been described in children.…”

“…10 , 16 AB lesions can occur at any age, but the peak incidence ranges from 30 to 60 years. 3 , 16–18 AB has also been described in children. 19 , 20 There are no data suggesting a geographic or racial difference.…”

“…Light microscopy of a fully developed AB lesion is characterized by a thin and flattened epidermis with local parakeratosis and focal spongiosis and varying melanin deposition in the basal layer, depending on the clinical hyper‐ or hypopigmentation. 16 , 72 , 74 , 77–81 The dermis is thickened and sclerotic with the disappearance of papillae. 74 , 78 This causes a scleroderma‐like appearance.…”

Vasculopatia livedoide: uma doença cutânea intrigante

“…37 The vessels of the vascular plexus of the deep dermis are involved only in rare occasions. 60,61 In addition to the presence of fibrinoid thrombus in the vascular lumen and sometimes the presence of fibrin on the vessel wall, in some cases, we can observe this fibrinoid material deposited in the perivascular stroma, which results in the classical clinical manifestation of "fibrinoid thrombus and fibrinoid rings" in the region of the superficial dermal vascular plexus. 21 This fibrinoid material can be clearly visualized through the PAS histochemical technique.…”