Atrial natriuretic peptides stimulate renal gluconeogenesis

Analogue-specific action in vitro of atrial natriuretic factor on human red blood cell Ca2+-ATPase activity.

“…9 How the gluconeogenic signal of ANF is distinguished by target cells from that relating to sodium handling is unclear, although we speculate that the structure-activity relationships for ANF we describe here do relate to carbohydrate metabolism. Renal tubular gluconeogenesis in vitro is maximally stimulated at 10~7 M ANF, 6 consistent with the concentration dependence we have reported for Ca 2+ -ATPase. We have reported a growth factor (erythropoietin) response in erythroid precursors that involves inhibition of membrane Ca 2+ -ATPase 21 and that is thought to contribute to erythropoietin-induced changes in RBC precursor Ca 2+ content.…”

“…Since ANF has been reported to decrease intracellular Ca 2+ concentration in isolated renal glomerular mesangial cells, 8 ATPase ("calcium pump") activity in that cell model would be inhibitory. On the other hand, ANF has gluconeogenic actions on kidney cells that are Ca 2+ -dependent 6 and are reproduced by the use of Ca 2+ ionophore. 9 How the gluconeogenic signal of ANF is distinguished by target cells from that relating to sodium handling is unclear, although we speculate that the structure-activity relationships for ANF we describe here do relate to carbohydrate metabolism.…”

“…6 The mechanisms of ANF actions are incompletely understood, but they are thought to involve enhanced guanylate cyclase activity (e.g., in the kidney) 7 and, perhaps, lowering of intracellular Ca 2+ concentrations. 8 On the other hand, the renal tubular gluconeogenic action of ANF is Ca 2+ -dependent, 6 and gluconeogenesis in the kid- …”

“…4 The diverse effects of ANF also include stimulation of arginine vasopressin secretion 5 and of renal gluconeogenesis. 6 The mechanisms of ANF actions are incompletely understood, but they are thought to involve enhanced guanylate cyclase activity (e.g., in the kidney) 7 and, perhaps, lowering of intracellular Ca 2+ concentrations. 8 On the other hand, the renal tubular gluconeogenic action of ANF is Ca 2+ -dependent, 6 and gluconeogenesis in the kid-ney is regulated in part by changes in intracellular Ca 2+ content.…”

“…6 The mechanisms of ANF actions are incompletely understood, but they are thought to involve enhanced guanylate cyclase activity (e.g., in the kidney) 7 and, perhaps, lowering of intracellular Ca 2+ concentrations. 8 On the other hand, the renal tubular gluconeogenic action of ANF is Ca 2+ -dependent, 6 and gluconeogenesis in the kid-ney is regulated in part by changes in intracellular Ca 2+ content. 9 We have recently used the red blood cell (RBC) membrane Ca 2+ -adenosine triphosphatase (ATPase) model to study structure-activity relationships in vitro of thyroid hormone analogues 10 and sex steroid analogues.…”