Atrazine induction of a family 4 cytochrome P450 gene in Chironomus tentans (Diptera: Chironomidae)

Londoño, Diana K.; Siegfried, Blair D.; Lydy, Michael J.

doi:10.1016/j.chemosphere.2003.12.001

Cited by 43 publications

(25 citation statements)

References 21 publications

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“…Atrazine induces P450-dependent activities and a CYP4-related P450 gene in the aquatic larvae of the midge Chironomus tentans (Miota et al, 2000;Londono et al, 2004). Atrazine induction of P450 activities has also been reported in Spodoptera larvae (Kao et al, 1995;Yu, 2004).…”

Section: Discussionmentioning

confidence: 87%

Xenobiotic response in Drosophila melanogaster: Sex dependence of P450 and GST gene induction

Goff

Hilliou

Siegfried

et al. 2006

Insect Biochemistry and Molecular Biology

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146

109

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Section: Discussionmentioning

confidence: 87%

Xenobiotic response in Drosophila melanogaster: Sex dependence of P450 and GST gene induction

Goff

Hilliou

Siegfried

et al. 2006

Insect Biochemistry and Molecular Biology

Self Cite

146

109

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“…Studies with Chironomus tentans exposed to atrazine have demonstrated an increase in cytochrome P450 monooxygenases or P450-dependent enzymes such as cytochrome P450-dependent O-deethylation [95], P450-dependent aldrine epoxidase [97], and O-demethylase [98]. Enhanced cytochrome P450 enzyme activities may increase the toxicity of OPs by enhancing their oxidative activation into the oxon-analogs metabolites which have higher anticholinesterase properties.…”

Section: Op Plus Triazinesmentioning

confidence: 99%

Cholinesterase and glutathione‐S‐transferase activities in freshwater invertebrates as biomarkers to assess pesticide contamination

Domingues

Agra

Monaghan

et al. 2009

Enviro Toxic and Chemistry

128

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Abstract-Studies investigating the use of biomarkers in pesticide risk assessment have greatly increased in recent years; however, issues concerning the ecological meaning of enzymatic responses have proved controversial. Ideally a good biomarker response should be modulated by the environmental contaminants alone and demonstrate a predictable behavior towards certain types of toxins. As these premises are rarely observed, the present study aims to outline research that has contributed to an understanding of the behavior of two widely used biomarkers, cholinesterase and glutathione-S-transferase, describing environmental and biotic factors that affect their response in freshwater invertebrates. Studies were performed in the main classes of aquatic invertebrates with these biomarkers and conclusions were reached concerning their behavior towards the main classes of pesticides. Links between biomarker responses and conventional endpoints were evaluated so that ecological relevance could be attributed to enzymatic responses. Toxicity of mixtures was investigated, and cases of synergism and antagonism were pointed out as factors changing the expected toxicity of aquatic systems and leading to misinterpretations of biomarker responses. Finally, the use of biomarkers as a tool for biomonitoring and in situ assays was investigated, with discussion of advantages and disadvantages of their use.

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“…The presence of cadmium reinforced the metabolic process and alleviated the adverse effect caused by permethrin. Londoño et al (2004) detected significant elevation of CYP450 enzyme activity in C. tentans exposed to atrazine from 1 to 10 mg/L for 90 h, but the induction was not noted when the concentration of atrazine was below 1 mg/L. At the same time, the cytochrome P450 family 4 gene was also over-expressed in C. tentans exposed to atrazine at 10 mg/L.…”

Section: Evidence From Gene Expressionmentioning

confidence: 63%

Does cadmium affect the toxicokinetics of permethrin in Chironomus dilutus at sublethal level? Evidence of enzymatic activity and gene expression

Chen

Zhang

et al. 2016

Environmental Pollution

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Atrazine induction of a family 4 cytochrome P450 gene in Chironomus tentans (Diptera: Chironomidae)

Cited by 43 publications

References 21 publications

Xenobiotic response in Drosophila melanogaster: Sex dependence of P450 and GST gene induction

Xenobiotic response in Drosophila melanogaster: Sex dependence of P450 and GST gene induction

Cholinesterase and glutathione‐S‐transferase activities in freshwater invertebrates as biomarkers to assess pesticide contamination

Does cadmium affect the toxicokinetics of permethrin in Chironomus dilutus at sublethal level? Evidence of enzymatic activity and gene expression

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