Atractyligenin, a terpenoid isolated from coffee silverskin, inhibits cutaneous photoaging

Xuan, Song Hua; Lee, Nam Ho; Park, Soo Nam

doi:10.1016/j.jphotobiol.2019.04.002

Cited by 17 publications

(11 citation statements)

References 30 publications

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“… 39 Atractyligenin, a terpenoid isolated from coffee silverskin, reduced UVA-induced oxidative damage by inhibiting intracellular ROS production. 40 Red and white wine extracts were shown to have significant antioxidant and anti-aging activity in H 2 O 2 -treated fibroblasts exposed to stressors, as reflected by CAT and β-galactosidase activities. 24 The results of our study demonstrate that MV helps skin fibroblasts resist oxidative stress by promoting the elimination of ROS and MDA by antioxidant enzymes, although this remains to be confirmed in vivo.…”

Section: Discussionmentioning

confidence: 95%

Protective Effects of Mogroside V on Oxidative Stress Induced by H2O2 in Skin Fibroblasts

Mo¹,

Fu²,

Zhao³

et al. 2021

DDDT

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Purpose Damage caused by oxidative stress leads to the premature aging of cells. Mogrosides, the main active components of Siraitia grosvenorii , have strong antioxidant activity; however, it is unclear whether mogroside V (MV) exerts these effects in skin cells. This was investigated in the present study by evaluating the protective effects of MV against oxidative damage induced by hydrogen peroxide (H 2 O 2 ) in skin fibroblasts. Methods Mouse skin fibroblasts (MSFs) were treated with H 2 O 2 and cell viability, total antioxidant capacity, reactive oxygen species (ROS) production, malondialdehyde (MDA) content, and antioxidant enzyme activity were assessed. Results Treatment with MV reduced the ROS level and MDA content in MSFs treated with H 2 O 2 . This was accompanied by increased superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities. Conclusion MV reduces H 2 O 2 -induced oxidative stress and enhances endogenous antioxidant activity in skin fibroblasts. Thus, MV can potentially be used as an ingredient in anti-aging cosmetic products.

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Section: Discussionmentioning

confidence: 95%

Protective Effects of Mogroside V on Oxidative Stress Induced by H2O2 in Skin Fibroblasts

Mo¹,

Fu²,

Zhao³

et al. 2021

DDDT

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“…This suggests that the carboxy, disulfuric, and isovaleric acid derivatives are responsible for inhibiting ATP production. Additionally, Xuan et al confirmed that noncarboxylated atractyligenin isolated from coffee silverskin exhibited antiphotoaging effects and may treat or prevent photoaging in human skin cells.…”

Section: Introductionmentioning

confidence: 98%

Identification of Phytochemical Compounds in Coffea arabica Whole Coffee Cherries and Their Extracts by LC-MS/MS

Nemzer

Abshiru

Al-Taher

2021

J. Agric. Food Chem.

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The current work assessed the phytochemical contents of Arabica whole coffee cherry (WCC) and its two commercially available extracts: a minimum 40% chlorogenic acid (CGA; WCCE-1) and 70% caffeine (WCCE-2). Mass spectrometry analyses tentatively identified 219 phytochemicals in the three coffee samples, which is, so far, the largest number of identifications in a single study. A new group of CGA derivative namely caffeoylvaleroylquinic acid (CVQA) was identified in the three samples. Moreover, three 5-hydroxytryptamide derivatives (C 20 -5HT, C 22 -5HT, and C 24 -5HT) were identified in WCC but not in the extracts. Two groups of atractyligenin derivatives (carboxyatractyligenin and noncarboxyatractyligenin) were identified in the three samples. Furthermore, our results show that both extracts retained a large number of phenolic and other potentially bioactive compounds that were naturally present in whole coffee cherry (WCC).

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“…6,25,27 A terpenoid isolated from an ethyl acetate fraction of coffee silverskin was reported to be capable of inhibiting ROS production and potential as photoaging agent. 12 Taken altogether, the cascara pulp obtained herein is potential in preventing photoaging attributed to its high antioxidant activity that could suppress the oxidative stress in skin tissue following solar radiation.…”

Section: Discussionmentioning

confidence: 86%

“…[9][10][11] Previously, cascara pulp has been extracted using water, methanol, or even supercritical CO 2 . 12,13 However, the use of ethanol solvent that could attract polar compounds and several non-polar compounds is scarcely reported. 14 The present study tried to close the gap by determining the phytometabolite profile of the ethanolic extract of C. arabica cascara pulp along with its antioxidant properties.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and phytometabolite profiles of ethanolic extract from the cascara pulp of Coffea arabica collected from Gayo Highland: A study for potential photoaging agent

et al. 2023

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Background: As the most abundant coffee by-product, cascara pulp has been considered a good source of antioxidants which could be used to prevent photoaging. The aim of this study was to determine the phytometabolite profiles, antioxidant and photoaging properties of the ethanolic extract of Coffea arabica cascara pulp. Methods: Ethanolic maceration was performed on the fine powder of C. arabica cascara pulp collected from Gayo Highland, Aceh Province, Indonesia. The filtrate obtained was evaluated for its 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, total phenolic content (TPC), and total flavonoid content (TFC). The phytometabolite profiling was conducted qualitatively using reagents and quantitatively using gas chromatography—mass spectroscopy (GC-MS). The potential of the cascara pulp phytometabolites in inhibiting activator protein-1 (AP-1) was evaluated through molecular docking. Results: The extract had TPC and TFC of 2.04 mg gallic acid equivalent/g extract and 91.81 mg quercetin equivalent/g extract, respectively. The half-maximal inhibitory concentration (IC50) for the DPPH inhibition reached as low as 9.59 mg/L. Qualitative phytocompound screening revealed the presence of alkaloids, saponins, tannins, flavonoids, steroids, quinones, polyphenols, and triterpenoids. GC-MS revealed the extract containing 5-hydroxy-methylfurfural (22.31%); 2,5 dimethyl 4 hidroxy 3(2H) furanone (0.74%); and caffeine (21.07%), which could form interaction with AP-1 with binding energies of -172.8, -150.8, and -63.188 kJ/mol, respectively. Conclusion: Ethanolic extract from C. arabica cascara pulp potentially have anti-photoaging properties which is worthy for further investigations in the future.

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Atractyligenin, a terpenoid isolated from coffee silverskin, inhibits cutaneous photoaging

Cited by 17 publications

References 30 publications

Protective Effects of Mogroside V on Oxidative Stress Induced by H2O2 in Skin Fibroblasts

Protective Effects of Mogroside V on Oxidative Stress Induced by H2O2 in Skin Fibroblasts

Identification of Phytochemical Compounds in Coffea arabica Whole Coffee Cherries and Their Extracts by LC-MS/MS

Antioxidant and phytometabolite profiles of ethanolic extract from the cascara pulp of Coffea arabica collected from Gayo Highland: A study for potential photoaging agent

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