ATR/Raman and Fractal Characterization of HPBCD/Progesterone Complex Solid Particles

Fini, Adamo; Ospitali, Francesca; Zoppetti, G; Puppini, Nadia

doi:10.1007/s11095-008-9593-4

Cited by 27 publications

(16 citation statements)

References 12 publications

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“…The Raman spectrum of the DDP standard exhibited sharp characteristic peaks between 1600 and 1700 cm , which could be attributed to the carbon-carbon double bond and carbonyl stretching vibration of the steroidal backbone. 26) These peaks coincided with those of the observed crystals in GP and GM; therefore, the observed crystals in GP and GM were identified as DDP. Refai and Muller-Goymann reported that changes in steroid permeation are dependent on the concentration of dissolved corticosteroid in the vehicle.…”

Section: Resultssupporting

confidence: 65%

Release Profiles of Dexamethasone Dipropionate from Admixtures of Steroid and Heparinoid Ointments Prepared by Different Mixing Methods

Suzuki

Uchino

Miyazaki

et al. 2012

CHEMICAL & PHARMACEUTICAL BULLETIN

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Characterization and release profiles of commercial dexamethasone dipropionate (DDP) from an innovator and 2 generic ointments (Methaderm (IM), Promethasone (GP), and Mainvate (GM)) and their admixtures with heparinoid ointment (Hirudoid Soft) were investigated. The admixtures were prepared using 2 mixing methods (slab or rotation/revolution mixer). Microscopic and FT-Raman spectrometric analyses revealed that the ointments, except for IM, contained DDP crystals. A silicone membrane was used for the evaluation of the DDP permeation. The permeated DDP amounts from GP and GM were lower than that from IM, indicating that DDP solubility in the ointment vehicle affected the release of DDP from the ointment. No significant differences were observed in DDP release between IM alone and its admixture prepared using a slab; however, DDP release from the admixture prepared using a rotation/revolution mixer was significantly lower than those from IM alone and its admixture by slab. In the GP system, DDP release from the admixtures by the 2 mixing methods was higher than that from GP alone, whereas no significant difference in DDP release between the 2 mixing methods was observed. No significant differences were observed between the GM and admixtures. The apparent solubility of DDP in the admixtures as determined by the ultracentrifugal separation method indicated that the DDP amount in the liquid phase of admixtures with GP was 6 times higher than that of admixtures with IM or GM. Therefore, the apparent solubility of DDP in the liquid phase in the GP system might influence the DDP release in admixtures.

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Section: Resultssupporting

confidence: 65%

Release Profiles of Dexamethasone Dipropionate from Admixtures of Steroid and Heparinoid Ointments Prepared by Different Mixing Methods

Suzuki

Uchino

Miyazaki

et al. 2012

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Em especial, as bandas características do OEC em 2835, 1639, 1611 e 1510 cm -1 tiveram uma acentuada redução de intensidade comparada aos espectros isolados do OEC e da MF, sugerindo que estas ligações possivelmente estão implicadas na formação destes complexos, visto que a inserção de uma molécula-hóspede no interior da cavidade da b-CD provoca uma restrição conformacional, reduzindo a livre movimentação das moléculas encapsuladas, reduzindo a intensidade do sinal. Esse mesmo efeito foi percebido por Fini, 39 Oliveira, 33 e Rocha 31 quando prepararam complexos de inclusão utilizando a b-CD. Além destes efeitos, observou-se ainda o deslocamento das bandas de estiramento OH da b-CD em 3346 cm -1 para 3338 cm -1 no CI e da banda de estiramento C -H da b-CD em 2928 cm -1 para 2919 cm -1 no CI, reforçando a teoria da formação do complexo de inclusão.…”

Section: Espectroscopia De Infravermelhounclassified

Preparação e caracterização do complexo de inclusão do óleo essencial de Croton zehntneri com β-ciclodextrina

Aguiar¹,

Lima²,

Rocha³

et al. 2014

Quím. Nova

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“…In the spectrum of pure progesterone (Fig. 4(a)), there are two sharp and well-resolved bands at 1662 cm −1 (ν 1 (C=O)) and 1698 cm −1 (ν 2 (C=O)) assigned to carbonylstretching bands of C 3 and C 20 , respectively, and a lessintensive band at 1615 cm −1 corresponding to the stretching vibration band of C=C (54)(55)(56).…”

Section: Ftir Spectroscopymentioning

confidence: 99%

Modeling of Progesterone Release from Poly(3-Hydroxybutyrate) (PHB) Membranes

et al. 2015

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Abstract. Poly(3-hydroxybutyrate) (PHB) biodegradable polymeric membranes were evaluated as platform for progesterone (Prg)-controlled release. In the design of new drug delivery systems, it is important to understand the mass transport mechanism involved, as well as predict the process kinetics. Drug release experiments were conducted and the experimental results were evaluated using engineering approaches that were extrapolated to the pharmaceutical field by our research group. Membranes were loaded with different Prg concentrations and characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR). SEM images showed that membranes have a dense structure before and after the progesterone addition. DSC and FTIR allowed determining the influence of the therapeutic agent in the membrane properties. The in vitro experiments were performed using two different techniques: (A) returning the sample to the receptor solution (constant volume of the delivery medium) and (B) extracting total volume of the receptor solution. In this work, we present a simple and accurate Blumped^second-order kinetic model. This lumped model considers the different mass transport steps involved in drug release systems. The model fits very well the experimental data using any of the two experimental procedures, in the range 0≤t≤∞ or 0≤M t ≤M ∞ . The drug release analysis using our proposed approaches is relevant for establishing in vitro--in vivo correlations in future tests in animals.

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ATR/Raman and Fractal Characterization of HPBCD/Progesterone Complex Solid Particles

Cited by 27 publications

References 12 publications

Release Profiles of Dexamethasone Dipropionate from Admixtures of Steroid and Heparinoid Ointments Prepared by Different Mixing Methods

Release Profiles of Dexamethasone Dipropionate from Admixtures of Steroid and Heparinoid Ointments Prepared by Different Mixing Methods

Preparação e caracterização do complexo de inclusão do óleo essencial de Croton zehntneri com β-ciclodextrina

Modeling of Progesterone Release from Poly(3-Hydroxybutyrate) (PHB) Membranes

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ATR/Raman and Fractal Characterization of HPBCD/Progesterone Complex Solid Particles

Cited by 27 publications

References 12 publications

Release Profiles of Dexamethasone Dipropionate from Admixtures of Steroid and Heparinoid Ointments Prepared by Different Mixing Methods

Release Profiles of Dexamethasone Dipropionate from Admixtures of Steroid and Heparinoid Ointments Prepared by Different Mixing Methods

Preparação e caracterização do complexo de inclusão do óleo essencial de Croton zehntneri com &#946;-ciclodextrina

Modeling of Progesterone Release from Poly(3-Hydroxybutyrate) (PHB) Membranes

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Preparação e caracterização do complexo de inclusão do óleo essencial de Croton zehntneri com β-ciclodextrina