Modeling of Progesterone Release from Poly(3-Hydroxybutyrate) (PHB) Membranes

Abstract

Abstract. Poly(3-hydroxybutyrate) (PHB) biodegradable polymeric membranes were evaluated as platform for progesterone (Prg)-controlled release. In the design of new drug delivery systems, it is important to understand the mass transport mechanism involved, as well as predict the process kinetics. Drug release experiments were conducted and the experimental results were evaluated using engineering approaches that were extrapolated to the pharmaceutical field by our research group. Membranes were loaded with different Prg concentrations and characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR). SEM images showed that membranes have a dense structure before and after the progesterone addition. DSC and FTIR allowed determining the influence of the therapeutic agent in the membrane properties. The in vitro experiments were performed using two different techniques: (A) returning the sample to the receptor solution (constant volume of the delivery medium) and (B) extracting total volume of the receptor solution. In this work, we present a simple and accurate Blumped^second-order kinetic model. This lumped model considers the different mass transport steps involved in drug release systems. The model fits very well the experimental data using any of the two experimental procedures, in the range 0≤t≤∞ or 0≤M t ≤M ∞ . The drug release analysis using our proposed approaches is relevant for establishing in vitro--in vivo correlations in future tests in animals.

Improvement of Mechanical Ductile Properties of Poly(3-hydroxybutyrate) by Using Vegetable Oil Derivatives

“…As it can be seen, the typical IR stretching bands of P3HB can be observed in all the studied formulations, as it is the main component in the plasticized formulations. The main IR absorbing bands of P3HB are located in the 3000–2900 cm −1 range, which corresponds to the CH stretching vibrations . A typical characteristic peak at 1720 cm −1 , attributed to the stretching vibrations of crystalline carbonyl groups CO can also be seen.…”

“…Among the wide variety of environmentally friendly polymers, poly(3‐hydroxybutyrate) (P3HB) is one of the most promising ones because of its excellent balanced properties such as disintegration in compost soil, biocompatibility, UV light resistance, mechanical features similar to polypropylene, etc . All these features make P3HB an excellent candidate for biomedicine applications, or disposable products from the packaging industry . P3HB is one of the best well known polymers pertaining to polyhydroxyalkanoates .…”

Films based on the biopolymer poly(3-hydroxybutyrate) as platforms for the controlled release of dexamethasone

“…This zone was selected since the characteristic peaks of DX are evident in these wavelength ranges, without overlapping with those of PHB. The complete PHB spectrum was described in a previous paper (Romero et al, 2016). In the DX spectrum, there were four sharp and well resolved bands.…”

“…The purpose of this research was to design and characterize DX loaded PHB films, and to evaluate the DX release from these matrices. Kinetic and transport phenomena involved in the release of the drug were considered by the “lumped model” developed and validated by our research group (Fernández-Colino et al, 2016, Romero et al, 2016, Romero et al, 2017). Pharmaceutic parameters were calculated and the influence of different DX loads on the release profiles was evaluated through similarity and difference factors.…”

Dissolution Profiles of Fenbendazole from Binary Solid Dispersions: A Mathematical Approach

“…Under this framework, the in vitro dissolution of FBZ samples containing P188 and P407 were modeled using the Lumped model [33,36,37] recently developed and validated [32,38]. This semi-empirical model is based on secondorder kinetics (Equation 1) where the driving force is the difference between the maximum amount of drug that the sample can release (M ∞ )(t → ∞) and the amount release at time t (M t ).…”